Alternative I-D Exchange
Reaction on Pyrimidine and Purine Nuclei Mediated by Tributyltin
Hydride Using THF-d8 as a
Deuterium Source

Tomonobu Mutsumi; Kazuo Maruhashi; Yasunari Monguchi; Hironao Sajiki

doi:10.1055/s-0028-1083548

LETTER

Alternative I-D Exchange Reaction on Pyrimidine and Purine Nuclei Mediated by Tributyltin Hydride Using THF-d ₈ as a Deuterium Source

Tomonobu Mutsumi*^a,b, Kazuo Maruhashi^a, Yasunari Monguchi^b, Hironao Sajiki^b
^a Chemical Technology Laboratory, Taiho Pharmaceutical Co., Ltd., 200-22 Kodama-Gun, Saitama 367-0241, Japan
Fax: +81(495)774598; e-Mail: t-mutsumi@taiho.co.jp;
^b Department of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan

Abstract

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Abstract

A method for the regioselective deuteration of pyrimidine and purine rings mediated by Bu₃SnH using THF-d ₈ as a deuterium source on the basis of a radical reaction was developed.

Key words

regioselective deuteration - pyrimidine - purine - THF-d ₈ - tributyltin hydride

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References

References and Notes

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Alternative I-D Exchange Reaction on Pyrimidine and Purine Nuclei Mediated by Tributyltin Hydride Using THF-d 8 as a Deuterium Source

Alternative I-D Exchange Reaction on Pyrimidine and Purine Nuclei Mediated by Tributyltin Hydride Using THF-d ₈ as a Deuterium Source