A One-Pot, Single-Solvent
Process for Tandem, Catalyzed C-H Borylation-Suzuki-Miyaura
Cross-Coupling Sequences

Peter Harrisson; James Morris; Patrick G. Steel; Todd B. Marder

doi:10.1055/s-0028-1087374

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Synlett 2009(1): 147-150
DOI: 10.1055/s-0028-1087374

CLUSTER

A One-Pot, Single-Solvent Process for Tandem, Catalyzed C-H Borylation-Suzuki-Miyaura Cross-Coupling Sequences

Peter Harrisson^a, James Morris^b, Patrick G. Steel*^a, Todd B. Marder*^a
^a Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
Fax: +44(191)3844737; e-Mail: todd.marder@durham.ac.uk; e-Mail: p.g.steel@durham.ac.uk;
^b Syngenta Ltd., Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK

Further Information

Publication History

Received 12 September 2008
Publication Date:
12 December 2008 (online)

Abstract
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Abstract

Methyl tert-butyl ether is a suitable solvent for iridium-catalyzed C-H borylation followed, in the same pot, by palladium-catalyzed Suzuki-Miyaura cross-coupling sequences, giving high yields of biaryls.

Key words

biaryls - cross-coupling - homogeneous catalysis - boronate ester - tandem reactions

References

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