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Fortschr Neurol Psychiatr 2011; 79(3): 171-188
DOI: 10.1055/s-0029-1246093
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© Georg Thieme Verlag KG Stuttgart · New York

Störungen des Hämostasesystems: Molekulare Mechanismen als Grundlage von Diagnostik und Therapie

Hemostatic Disorders: Clinical Management Based on Molecular MechanismsR. E. Scharf1
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Publication Date:
10 March 2011 (online)

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Lernziele

Die vorliegende Übersicht befasst sich mit der Physiologie, Pathophysiologie und klinisch-praktischen Aspekten des Hämostasesystems. Ziel ist es, folgende Kenntnisse zu vermitteln:

Komponenten des Hämostasesystems und ihre Funktion im Blutstillungsmechanismus, Stellgrößen und Störungen des hämostatischen Gleichgewichts, molekulare Mechanismen der Thrombozyten-Gefäßwand-Interaktion, Steuerung der plasmatischen Hämostase und Fibrinolyse, Thrombomodulin-Protein-C-System und Resistenz gegenüber aktiviertem Protein C, expositionelle und dispositionelle Ursachen einer Thromboseneigung, Potenzierung genetisch bedingter Kombinationsdefekte in Risikosituationen, angeborene und erworbene Ursachen einer Blutungsneigung, von-Willebrand-Faktor und von-Willebrand-Syndrom, antithrombotische Substanzen und deren Wirkmechanismus.

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Prof. Rüdiger Eberhard Scharf

Institut für Hämostaseologie, Hämotherapie und Transfusionsmedizin, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität

Moorenstraße 5

40225 Düsseldorf

Email: rscharf@uni-duesseldorf.de