Background and study aim: Minimally invasive treatment has become a mainstay management strategy for early
gastric cancer (EGC). Full-thickness incision of the gastric wall using natural orifice
transluminal endoscopic surgery (NOTES) has been reported but is not easily applicable
in clinical settings at present. The aim of the current study was to assess the feasibility
of hybrid NOTES, which consists of endoscopic full-thickness gastric resection and
a laparoscopic lymphadenectomy.
Patients and methods: This was a prospective, pilot study at a single tertiary care referral center. A
total of 14 patients with EGC located above the lower third of the stomach underwent
hybrid NOTES. Clinically, the patients had contraindications to exclusive treatment
using endoscopic submucosal dissection (ESD). The main outcome measure was technical
success of hybrid NOTES.
Results: All cases were resected en bloc with negative surgical margins. Histologically, four
cases were mucosal cancers, and 10 cases were submucosal cancers. The median tumor
size was 26 mm (range 12 – 90 mm). Lymphatic vessel invasion was found in four cases
without lymph node metastasis (LNM). The median number of obtained lymph nodes was
18 (range 7 – 67). LNM was discovered in one case of undifferentiated submucosal cancer
without lymphovascular invasion. Hybrid NOTES was conducted without intraoperative
or postoperative adverse events in nine cases. The median operating time and estimated
blood loss of successful cases were 143 minutes (range 110 – 253 minutes) and 16 mL
(range 5 – 30 mL), respectively. The median hospital stay was 6 days (range 4 – 10
days). Five cases were converted to a subtotal gastrectomy for various reasons.
Conclusions: Hybrid NOTES could be a bridge between endoscopic resection and laparoscopic surgery
and may prevent extensive gastrectomy in patients with EGC.
References
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