Access to Saturated Fused Pyrimidine Derivatives via a Flexible N-Vinyl Tertiary Enamide Synthesis

Abstract

An array of tetrasubstituted saturated fused pyrimidines has been synthesized through two-sequential, simple, and efficient one-pot operations. The strategic utilization of the N-PMB group proved critical in the ability to construct a broad range of N-vinyl tertiary enamide starting materials. This stands as a flexible approach to functionalized pyrimidines with the capability of manipulating either ketone, acid chloride, or nitrile reaction partners.

bicyclic compounds - enamides - imines - medicinal chemistry - pyrimidines

References and Notes

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