ABSTRACT
A simple and rapid global haemostatic assay for determination of the overall hemostasis
potential (OHP) in plasma represents a new approach in detecting alterations in the
delicate balance between coagulation and fibrinolysis. The assay is based on repeated
spectrophotometric registration of the fibrin-aggregation curve in platelet-poor plasma
containing small amounts of exogenous thrombin, tissue-type plasminogen activator,
and calcium. The overall coagulation potential and overall fibrinolytic potential
are supplementary parameters of OHP, providing details of underlying changes in coagulation
and/or fibrinolysis. The OHP assay was evaluated in connection with hypercoagulation
in normal pregnancy, preeclampsia, some thrombophilias, coronary heart disease, diabetes,
stroke, and vascular surgery as well as with hypocoagulability, especially in patients
with hemophilia A or B. Preliminary results also indicate the possible usefulness
of the assay in monitoring anticoagulant treatments. Large prospective clinical trials
are needed before the method can be recommended for routine clinical application.
KEYWORDS
Global haemostatic assay - Overall Haemostatic Potential (OHP) - hypercoagulability
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Aleksandra AntovicM.D. Ph.D.
Karolinska Institutet, Department of Clinical Sciences
Danderyd Hospital, KFC Norr, hus 8, plan 6, 182 88 Stockholm, Sweden
Email: aleksandra.antovic@ki.se
