Zusammenfassung
Die adjuvante Therapie des differenzierten Schilddrüsenkarzinoms mit radioaktivem
Iod ist das Standardverfahren für die Ablation des Restschilddrüsengewebes nach Operation
und für die Behandlung von iodaviden Metastasen. Meist werden zur Behandlung Standardaktivitäten
verabreicht. Zusätzlich gibt es aber 2 dosimetrische Konzepte für die Behandlung des
Schilddrüsenkarzinoms mittels Radioiod: a) Die Begrenzung der Blutdosis auf 2 Gy und
b) die Optimierung der Energiedosen für iodavide Läsionen. Beide Konzepte und deren
klinische Anwendungen und Ergebnisse sowie neue Methoden zur Einbeziehung radiobiologischer
Überlegungen werden beschrieben.
Abstract
Adjuvant therapy of differentiated thyroid cancer with radioactive iodine is a standard
procedure for the ablation of remnant thyroid tissue following surgery and for the
treatment of iodine avid metastases. In most cases fixed activities are administered.
Presently there are two dosimetric approaches for the treatment of thyroid cancer
using radioiodine: a) the 2 Gy bone marrow dose limited approach and b) the optimization
of the absorbed dose to iodine avid lesions. Both concepts and their clinical applications
and, in addition, new dosimetric methods which include radiobiological considerations
are described.
Schlüsselwörter
Schilddrüsenkarzinom - Dosimetrie - I-131 Therapie
Key words
thyroid cancer - dosimetry - I-131 therapy
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Korrespondenzadresse
Prof. Michael Lassmann
Klinik und Poliklinik für
Nuklearmedizin
Universität Würzburg
Oberdürrbacher Straße 6
97080 Würzburg
Phone: +49/931/201 35500
Fax: +49/931/201 61803
Email: Lassmann_m@klinik.uni-wuerzburg.de
