pH Buffering Does not Influence BDNF Responses to Exercise

S. Rojas Vega; W. Hollmann; B. Vera Wahrmann; H. K. Strüder

doi:10.1055/s-0031-1285929

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2012; 33(01): 8-12
DOI: 10.1055/s-0031-1285929

Physiology & Biochemistry

pH Buffering Does not Influence BDNF Responses to Exercise

Authors

S. Rojas Vega

¹German Sport University Cologne, Institute of Movement and Neurosciences, Cologne, Germany
W. Hollmann

²German Sport University Cologne, Institute of Cardiology and Sports Medicine, Cologne, Germany
B. Vera Wahrmann

³San Antonius Hospital, Cologne, Department of Anesthesiology, Cologne, Germany
H. K. Strüder

¹German Sport University Cologne, Institute of Movement and Neurosciences, Cologne, Germany

Abstract

The influence of acidosis on brain-derived neurotrophic factor (BDNF) was examined by buffering pH changes during 10 min of continuous low intensity (LIE) and following high intensity cycling exercise to exhaustion (HIE). 11 athletes participated in 2 trials separated by 1 week. Individuals received either a placebo infusion (isotonic saline) or an isotonic sodium bicarbonate infusion before and during exercise. Blood samples were drawn at rest, after LIE and after HIE, as well as 3, 6, 10 and 15 min post exercise. During placebo trial, HIE induced a profound decrease (p<0.01) of capillary blood bicarbonate concentration (HCO₃ˉ), pH, base excess (BE) and pCO₂. Higher (p<0.01) HCO₃ˉ, pH and BE were found during bicarbonate infusion and post exercise in comparison to the placebo trial. Exercise induced an identical increase of blood lactate concentration in both trials. Serum BDNF concentration was increased (p<0.01) at the end of HIE and remained elevated until 3 min post exercise in both trials. The present study suggests that during HIE lactate might have an acidosis-independed impact on BDNF secretion because buffering of blood gases, that attenuate the fall of pH but not the accumulation of lactic acid, failed to alter the exercise-induced increase of BDNF.

Key words

acidosis - alkalosis - brain-derived neurotrophic factor - high intensity exercise

Full Text

References

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