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Synlett 2012; 23(12): 1779-1782
DOI: 10.1055/s-0031-1290698
DOI: 10.1055/s-0031-1290698
letter
An Optimised Synthesis of 2-[2,3-Bis(tert-butoxycarbonyl)guanidino]ethylamine
Authors
Further Information
Publication History
Received: 13 April 2012
Accepted after revision: 14 May 2012
Publication Date:
04 July 2012 (online)
Abstract
This short report describes an improved, reliable, and high-yielding (>90%) synthesis of 2-[2,3-bis(tert-butoxycarbonyl)guanidino]ethylamine. The method is scalable (>5 g), and the product obtained directly from the reaction mixture requires no further purification. In addition, this methodology can be successfully applied to other diamine substrates (1,3-propyl and 1,4-butyl; 70% and 61% yield, respectively).
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- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information (PDF)
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References and Notes
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