Oxazole Synthesis from Isocyanides

Laurent El Kaïm; Laurence Grimaud; Pravin Patil

doi:10.1055/s-0031-1290939

Synlett, Table of Contents

Synlett 2012; 23(9): 1361-1363
DOI: 10.1055/s-0031-1290939

letter

Oxazole Synthesis from Isocyanides

Authors

Laurent El Kaïm*

Laboratoire DCSO ENSTA-Polytechnique-CNRS, UMR 7652, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris, Cedex 15, France, Fax: +33(1)45528322 Email: laurent.elkaim@ensta.fr Email: grimaud@dcso.polytechnique.fr
Laurence Grimaud*

Laboratoire DCSO ENSTA-Polytechnique-CNRS, UMR 7652, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris, Cedex 15, France, Fax: +33(1)45528322 Email: laurent.elkaim@ensta.fr Email: grimaud@dcso.polytechnique.fr
Pravin Patil

Laboratoire DCSO ENSTA-Polytechnique-CNRS, UMR 7652, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris, Cedex 15, France, Fax: +33(1)45528322 Email: laurent.elkaim@ensta.fr Email: grimaud@dcso.polytechnique.fr

Abstract

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Abstract

A new synthetic path toward oxazoles starting from isocyanides is presented. This two-step oxazole preparation involves a bromination–cyclization followed by a Suzuki cross-coupling.

Key words

oxazoles - Suzuki - palladium - isocyanides - dihalogenoisocyanides

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References

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