Endoscopy 2012; 44(03): 293-296
DOI: 10.1055/s-0031-1291592
Case report/series
© Georg Thieme Verlag KG Stuttgart · New York

A switch to endoscopic mucosal resection after precutting following gastric perforation during endoscopic submucosal dissection: a simple and useful technique

D. W. Lee
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
,
H. S. Lee
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
,
M. K. Jung
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
,
S. K. Kim
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
,
S. W. Jeon
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
› Author Affiliations
Further Information

Publication History

submitted 21 July 2011

accepted after revision 11 October 2011

Publication Date:
21 February 2012 (online)

Endoscopic submucosal dissection (ESD) is safe and effective, but as the number of patients undergoing ESD has increased, so has the number of iatrogenic perforations. We describe the effectiveness and benefits of endoscopic mucosal resection after precutting (EMR-P) in a series of patients who developed a macroperforation during ESD. This was a retrospective, single-center case series from a prospectively maintained database in an academic tertiary care center. The study involved 16 patients with macroperforation out of 1171 patients who underwent ESD between November 2006 and January 2011. En bloc resection by EMR-P was achieved in 12 out of 16 patients (75 %) and piecemeal resection in 4 (25 %). All patients were discharged after a mean hospital stay of 6.8 days without further complications. There were no recurrences during the median follow-up period of 11.4 months. Macroperforation during ESD can be managed successfully by endoscopic closure, and EMR-P should then be considered.

 
  • References

  • 1 Oyama T, Tomori A, Hotta K et al. Endoscopic submucosal dissection of early esophageal cancer. Clin Gastroenterol Hepatol 2005; 3: S67-S70
  • 2 Gotoda T. A large endoscopic resection by endoscopic submucosal dissection procedure for early gastric cancer. Clin Gastroenterol Hepatol 2005; 3: S71-S73
  • 3 Yamamoto H, Yahagi N, Oyama T. Mucosectomy in the colon with endoscopic submucosal dissection. Endoscopy 2005; 37: 764-768
  • 4 Jeong G, Lee JH, Yu MK et al. Non-surgical management of microperforation induced by EMR of the stomach. Dig Liver Dis 2006; 38: 605-608
  • 5 Kojima T, Parra-Blanco A, Takahashi H et al. Outcome of endoscopic mucosal resection for early gastric cancer: review of the Japanese literature. Gastrointest Endosc 1998; 48: 550-554
  • 6 Minami S, Gotoda T, Ono H et al. Complete endoscopic closure of gastric perforation induced by endoscopic resection of early gastric cancer using endoclips can prevent surgery (with video). Gastrointest Endosc 2006; 63: 596-601
  • 7 Fujishiro M, Yahagi N, Kakushima N et al. Successful nonsurgical management of perforation complicating endoscopic submucosal dissection of gastrointestinal epithelial neoplasms. Endoscopy 2006; 38: 1001-1006
  • 8 Shimizu Y, Kato M, Yamamoto J et al. Endoscopic clip application for closure of esophageal perforations caused by EMR. Gastrointest Endosc 2004; 60: 636-639
  • 9 Tsunada S, Ogata S, Ohyama T et al. Endoscopic closure of perforations caused by EMR in the stomach by application of metallic clips. Gastrointest Endosc 2003; 57: 948-951
  • 10 Taku K, Sano Y, Fu KI et al. Iatrogenic perforation at therapeutic colonoscopy: should the endoscopist attempt closure using endoclips or transfer immediately to surgery?. Endoscopy 2006; 38: 428
  • 11 Nakagawa Y, Nagai T, Soma W et al. Endoscopic closure of a large ERCP-related lateral duodenal perforation by using endoloops and endoclips. Gastrointest Endosc 2010; 72: 216-217
  • 12 Mutignani M, Iacopini F, Dokas S et al. Successful endoscopic closure of a lateral duodenal perforation at ERCP with fibrin glue. Gastrointest Endosc 2006; 63: 725-727
  • 13 Seewald S, Soehendra N. Perforation: part and parcel of endoscopic resection?. Gastrointest Endosc 2006; 63: 602-605
  • 14 Min BH, Lee JH, Kim JJ et al. Clinical outcomes of endoscopic submucosal dissection (ESD) for treating early gastric cancer: comparison with endoscopic mucosal resection after circumferential precutting (EMR-P). Dig Liver Dis 2009; 41: 201-209
  • 15 Yahagi N, Fujishiro M, Kakushima N et al. Endoscopic submucosal dissection for early gastric cancer using the tip of an electro-surgical snare (thin type). Dig Endosc 2004; 16: 34-38
  • 16 Yahagi N, Fujishiro M, Imagawa A et al. Endoscopic submucosal dissection for the reliable en bloc resection of colorectal mucosal tumors. Dig Endosc 2004; 16: S89-S92
  • 17 Fujishiro M, Yahagi N, Kashimura K et al. Comparison of various submucosal injection solutions for maintaining mucosal elevation during endoscopic mucosal resection. Endoscopy 2004; 36: 579-583
  • 18 Fujishiro M, Yahagi N, Kashimura K et al. Tissue damage of different submucosal injection solutions for endoscopic mucosal resection. Gastroinitest Endosc 2005; 62: 933-942
  • 19 Fujishiro M, Yahagi N, Nakamura M et al. Successful outcomes of a novel endoscopic treatment for GI tumors: endoscopic submucosal dissection with a mixture of high- molecular-weight hyaluronic acid, glycerin, and sugar. Gastroinitest Endosc 2006; 63: 243-249
  • 20 Gotoda T, Oda I, Tamakawa K et al. Prospective clinical trial of magnetic-anchor-guided endoscopic submucosal dissection for large early gastric cancer (with videos). Gastrointest Endosc 2009; 69: 10-15