Diet and Exercise Improve Neutrophil to Lymphocyte Ratio in Overweight Adolescents

R. Wang; P. J. Chen; W. H. Chen

doi:10.1055/s-0031-1297985

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2011; 32(12): e1-e5
DOI: 10.1055/s-0031-1297985

Immunology

Diet and Exercise Improve Neutrophil to Lymphocyte Ratio in Overweight Adolescents

Authors

R. Wang

¹Shanghai University of Sport, Department of Sports Medicine, Shanghai, China
P. J. Chen

¹Shanghai University of Sport, Department of Sports Medicine, Shanghai, China
W. H. Chen

¹Shanghai University of Sport, Department of Sports Medicine, Shanghai, China

Abstract

Neutrophil to lymphocyte ratio and levels of pro-inflammatory cytokines were evaluated in overweight, male Chinese adolescents upon completing a 4-week diet and physical exercise intervention. 43 recruited, non-randomized adolescents (body mass index >25 kg/m²) completed the controlled study. Anthropometric and biologic parameters were measured pre- and post-intervention. After the 4-week intervention, participants exhibited a significant decrease in body mass, body mass index, percentage body fat, basal heart rate, diastolic blood pressure, and all body shape indices tested. A significant decrease in serum lipids (except high-density lipoprotein cholesterol) and insulin levels was observed post-intervention. The neutrophil to lymphocyte ratio was significantly lower post-intervention. Bivariate correlation analyses showed that decrement in Δneutrophil to lymphocyte ratio significantly correlated with decrement in Δinterleukin-6 and Δwhite blood cell count. Thus, a 4-week diet and physical exercise intervention significantly reduces the neutrophil to lymphocyte ratio in a population of overweight, male adolescents. Weight loss caused by the intervention was associated with a significant decrease of pro-inflammatory cytokine levels.

Key words

obesity - NLR - IL-6 - leukocytes

Volltext

Referenzen

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