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J Neurol Surg A Cent Eur Neurosurg 2012; 73(05): 289-295
DOI: 10.1055/s-0032-1304813
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effects of Acute Intracranial Hypertension on Extracerebral Organs: A Randomized Experimental Study in Pigs

Jan Florian Heuer
1   Department of Anaesthesiology, Emergency and Intensive Care Medicine, University Hospital Göttingen, Göttingen, Germany
,
Maren Selke
2   Department of Cardiology, University Hospital Göttingen, Göttingen, Germany
,
Thomas A. Crozier
1   Department of Anaesthesiology, Emergency and Intensive Care Medicine, University Hospital Göttingen, Göttingen, Germany
,
Paolo Pelosi
3   Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy
,
Peter Herrmann
1   Department of Anaesthesiology, Emergency and Intensive Care Medicine, University Hospital Göttingen, Göttingen, Germany
,
Christina Perske
4   Department of Pathology, University Hospital Göttingen, Göttingen, Germany
,
Michael Quintel
1   Department of Anaesthesiology, Emergency and Intensive Care Medicine, University Hospital Göttingen, Göttingen, Germany
› Author Affiliations
Further Information

Publication History

23 August 2011

28 November 2011

Publication Date:
16 August 2012 (online)

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Abstract

Background The study was conducted to determine the effects of isolated acute intracranial hypertension (AICH) on extracerebral organs.

Design A total of 14 mechanically ventilated pigs were randomized to two groups of seven each: (1) control and (2) AICH.

Methods AICH was induced by inflating an intracranial balloon catheter. The inflation volume was adjusted to keep intracranial pressure between 30 and 40 cm H2O. Hemodynamics, gas-exchange, and global oxygen delivery parameters were observed over a 4-hour period. At the end of the 4-hour period, tissue samples of heart, lungs, liver, and kidneys were collected and histologically graded for inflammation, edema, and cell damage (necrosis) using semiquantitative scores.

Results Animals with AICH had increased heart rate and cardiac output, and higher scores for inflammation, edema, and necrosis in heart, lung, kidney, and liver tissues (all p < 0.05). Peripheral and mixed-venous oxygen saturations were unaffected.

Conclusions Isolated AICH induces injury to multiple extracerebral organs, even in the absence of hypoperfusion or hypoxemia.

Keywords

acute intracranial hypertension - multiple organ dysfunction - organ cross-talk

Supplementary Material

 

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