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DOI: 10.1055/s-0032-1304895
Effektivität und Sicherheit von Vareniclin zur Raucherentwöhnung
Effectiveness and safety of varenicline for smoking cessationPublication History
29 November 2011
09 February 2012
Publication Date:
10 April 2012 (online)
Zusammenfassung
Der Tabakkonsum ist eines der bedeutendsten vermeidbaren Mortalitäts- und Morbiditätsrisiken. Folglich ist die Entwicklung neuer Strategien zur Raucherentwöhnung eine entscheidende medizinische Herausforderung. Vareniclin, ein Partialagonist am nikotinischen α4β2-Acetylcholinrezeptor, wurde speziell zur Raucherentwöhnung entwickelt. Die Wirksamkeit von Vareniclin wurde in unabhängigen Studien bewiesen, in denen die Substanz den bisher zur Raucherentwöhnung eingesetzten Medikamenten (Bupropion und Nikotinersatztherapie) signifikant überlegen war. Vareniclin wurde jedoch auch mit schwerwiegenden kardiovaskulären und neuropsychiatrischen Nebenwirkungen assoziiert. Dieser Beitrag beurteilt die aktuelle Studienlage zur Effektivität und insbesondere zur Sicherheit einer Vareniclin-Therapie zur Raucherentwöhnung.
Abstract
Smoking is one of the major avoidable risks for mortality and morbidity. Thus developing new strategies for smoking cessation is a crucial medical challenge. Varenicline is an α4β2 nicotinic acetylcholine receptor partial agonist developed especially for smoking cessation. Several trials proved the efficacy of varenicline and its superiority to other medications for smoking cessation (bupropion and nicotine replacement therapy). Varenicline was associated with severe cardiovascular and neuro-psychiatric side effects. This article discusses the current research data on efficacy and safety of varenicline therapy for smoking cessation.
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