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Synlett 2012; 23(18): 2623-2626
DOI: 10.1055/s-0032-1317446
letter
© Georg Thieme Verlag Stuttgart · New York

Solvent-Free Pivalic Acid/Copper Chloride Jointly Promoted Chlorination of 1,2,3-Triazoles

Christophe Menendez
a   CNRS, Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, SPCMIB, UMR-5068, 118 Route de Narbonne, 31062 Toulouse cedex 9, France
b   Université de Toulouse, UPS, Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, SPCMIB, 118 route de Narbonne, 31062 Toulouse cedex 9, France
,
Nathalie Saffon
c   Université de Toulouse, UPS, and CNRS, ICT FR2599, 118 route de Narbonne, 31062 Toulouse, France   Fax: +33(5)61556011   Email: lherbet@chimie.ups-tlse.fr   Email: baltas@chimie.ups-tlse.fr
,
Christian Lherbet*
a   CNRS, Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, SPCMIB, UMR-5068, 118 Route de Narbonne, 31062 Toulouse cedex 9, France
b   Université de Toulouse, UPS, Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, SPCMIB, 118 route de Narbonne, 31062 Toulouse cedex 9, France
,
Michel Baltas*
a   CNRS, Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, SPCMIB, UMR-5068, 118 Route de Narbonne, 31062 Toulouse cedex 9, France
b   Université de Toulouse, UPS, Laboratoire de Synthèse et Physico-Chimie de Molécules d’Intérêt Biologique, SPCMIB, 118 route de Narbonne, 31062 Toulouse cedex 9, France
› Author Affiliations
Further Information

Publication History

Received: 26 June 2012

Accepted after revision: 20 September 2012

Publication Date:
18 October 2012 (online)

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Abstract

A novel chlorination reaction on the 5-position of 1,2,3-triazoles, directly from 5H-substituted 1,2,3-triazoles was developed by using copper(II) chloride in pivalic acid. A series of triazoles were thus chlorinated in low to good yields.

Key words

chlorination - triazole - copper chloride - pivalic acid

Supporting Information

    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
  • Supporting Information
 

  • References and Notes

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