Benigne Stimmlippentumore

A. Pickhard; R. Reiter

doi:10.1055/s-0032-1331162

Laryngo-Rhino-Otologie, Inhaltsverzeichnis

Laryngorhinootologie 2013; 92(05): 304-312
DOI: 10.1055/s-0032-1331162

Übersicht

Benigne Stimmlippentumore

Benign Vocal Fold Lesions

A. Pickhard

¹Hals-Nasen-Ohrenklinik, Technische Universität München, München

,

R. Reiter

²HNO, Sektion Phoniatrie, Univ.-Klinik Ulm, Ulm

› Institutsangaben

Abstract

Zusammenfassung

Zu den benignen Tumoren der Stimmlippen gehören epitheliale Läsionen wie Papillome, Läsionen des Reinkeraums (Stimmlippenknötchen, Stimmlippenpolypen, Stimmlippenzysten und das Reinkeödem selbst als Sonderform einer chronischen Entzündung) sowie Alterationen des Aryknorpels (Kontakt- bzw. Intubationsgranulome). Eine multifaktorielle Genese dieser Raumforderungen wird vermutet, wobei eine Stimmüberlastung mit Heiserkeit und Sprechanstrengung als wesentliches Charakteristikum ursächlich oder auch als Folge auftreten kann.

Abstract

Benign Vocal Fold Lesions

Benign vocal fold lesions are grouped in lesions arising from the epithelium like papillomas, lesions affecting the Reinke’s space (nodules, polyps, cysts, Reinkes’s edema as a form of chronic laryngits) and lesions affecting the arytenoid (granulomas). A multifactorial genesis is assumed. Main symptoms are dysphonia and hyperfunctional vocal behavior that might also be a cause of these lesions.

Schlüsselwörter

Stimmlippenpolypen - Stimmlippenzysten - Granulome - Stimme - Dysphonie

Key words

polyps - granuloma - cysts - voice - dysphonia

Volltext

Referenzen

Literatur
1 Altman KW. Vocal fold masses. Otolaryngol Clin North Am 2007; 40: 1091-1108
2 Titze IR. Mechanical stress in phonation. J Voice 1994; 8: 99-105
3 Johns MM. Update on the etiology, diagnosis, and treatment of vocal fold nodules, polyps, and cysts. Curr Opin Otolaryngol Head Neck Surg 2003; 11: 456-461
4 Courey MS, Shohet JA, Scott MA, Ossoff RH. Immunohistochemical characterization of benign laryngeal lesions. Ann Otol Rhinol Laryngol 1996; 105: 525-531
5 Gunter HE. Modeling mechanical stresses as a factor in the etiology of benign vocal fold lesions. J Biomech 2004; 37: 1119-1124
6 Gray SD, Hammond E, Hanson DF. Benign pathologic responses of the larynx. Ann Otol Rhinol Laryngol 1995; 104: 13-18
7 Jiang JJ, Titze IR. Measurement of vocal fold intraglottal pressure and impact stress. J Voice 1998; 8: 132-144
8 Andrade DF, Heuer R, Hockstein NE, Castro E, Spiegel JR, Sataloff RT. The frequency of hard glottal attacks in patients with muscle tension dysphonia, unilateral benign masses and bilateral benign masses. J Voice 2000; 14: 240-246
9 Marcotullio D, Magliulo G, Pietrunti S, Suriano M. Exudative laryngeal diseases of Reinke’s space: a clinicohistopathological framing. J Otolaryngol 2002; 31: 376-380
10 Thibeault SL. Advances in our understanding of the Reinke space. Curr Opin Otolaryngol Head Neck Surg 2005; 13: 148-151
11 Duflo SM, Thibeault SL, Li W, Smith ME, Schade G, Hess MM. Differential gene expression profiling of vocal fold polyps and Reinke’s edema by complementary DNA microarray. Ann Otol Rhinol Laryngol 2006; 115: 703-714
12 Hammond TH, Gray SD, Butler JE. Age- and gender-related collagen distribution in human vocal folds. Ann Otol Rhinol Laryngol 200; 109: 913-920
13 Hirano M. Clinical examination of voice. Wien, New York: Springer Verlag; 1981: 100
14 Hirano M. Structure and vibratory patterns of the vocal folds. In: Swashima N, Cooper PS. (eds.). Dynamic aspects of speech production. Tokyo: University of Tokyo Press; 1977: 13-27
15 Nawka T, Wirth G. Stimmstörungen. Für Ärzte, Logopäden, Sprachheilpädagogen und Sprechweissenschaflter. 5. Auflage. Deutscher Ärzte-Verlag; Köln: 2008: 1-452
16 Rosen CA, Murry T. Nomenclature of voice disorders and vocal pathology. Otolaryngol Clin North Am 2000; 33: 1035-1046
17 Remacle M, Friedrich G, Dikkers FG, de Jong F. Phonosurgery of the vocal folds: a classification proposal. Eur Arch Otorhinolaryngol 2003; 260: 1-6
18 Sataloff RT, Spiegel JR, Hawkshaw MJ. Strobovideolaryngoscopy: results and clinical value. Ann Otol Rhinol Laryngol 1991; 100: 725-727
19 Nagata K, Kurita S, Yasumoto S, Maeda T, Kawasaki H, Hirano M. Vocal fold polyps and nodules. A 10-year review of 1 156 patients. Auris Nasus Larynx 1983; 10: 27-35
20 Kunduk M, McWhorter AJ. True vocal fold nodules: the role of differential diagnosis. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 449-452
21 Dikkers FG, Nikkels PG. Benign lesions of the vocal folds: histopathology and phonotrauma. Ann Otol Rhinol Laryngol 1995; 104: 698-703
22 Kotby MN, Nassar AM, Seif EI, Helal EH, Saleh MM. Ultrastructural features of vocal fold nodules and polyps. Acta Otolaryngol 1988; 105: 477-482
23 Dikkers FG, Nikkels PG. Lamina propria of benign lesions of the vocal folds. Laryngoscope 109 1999; 1684-1689
24 Tao C, Jiang JJ. Mechanical stress during phonation in a self-oscillating finite-element vocal fold model. J Biomech 2007; 40: 2191-2198
25 De Bodt MS, Ketelslagers K, Peeters T, Wuyts FL, Mertens F, Pattyn J, Heylen L, Peeters A, Boudewyns A, Van de Heyning P. Evolution of vocal fold nodules from childhood to adolescence. J Voice 2007; 21: 151-156
26 Roy N, Merrill RM, Thibeault S, Parsa RA, Gray SD, Smith EM. Prevalence of voice disorders in teachers and the general population. J Speech Lang Hear Res 2004; 47: 281-293
27 Karkos PD, McCormick M. The etiology of vocal fold nodules in adults. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 420-423
28 Smolander S, Huttunen K. Voice problems experienced by Finnish comprehensive school teachers and realization of occupational health care. Logoped Phoniatr Vocol 2006; 31: 166-171
29 Sułkowski WJ, Kowalska S. Occupational voice disorders: an analysis of diagnoses made and certificates issued in 1999-2004. Int J Occup Med Environ Health 2005; 18: 341-349
30 Ratajczak J, Grzywacz K, Wojdas A, Rapiejko P, Jurkiewicz D. Role of psychological factors in pathogenesis of disturbances of voice caused with vocal nodules. Otolaryngol Pol 2008; 62: 758-763
31 Roy N, Bless DM, Heisey D. Personality and voice disorders: a multitrait-multidisorder analysis. J Voice 2006; 14: 521-548
32 Ulualp SO, Toohill RJ, Shaker R. Pharyngeal acid reflux in patients with single and multiple otolaryngologic disorders. Otolaryngol Head Neck Surg 1999; 121: 725-730
33 Kuhn J, Toohill RJ, Ulualp SO, Kulpa J, Hofmann C, Arndorfer R, Shaker R. Pharyngeal acid reflux events in patients with vocal cord nodules. Laryngoscope 1998; 108: 1146-1149
34 Hocevar-Boltezar I, Radsel Z, Zargi M. The role of allergy in the etiopathogenesis of laryngeal mucosal lesions. Acta Otolaryngol Suppl 1997; 527: 134-137
35 Colton RH, Woo P, Brewer DW, Griffin B, Casper J. Stroboscopic signs associated with benign lesions of the vocal folds. J Voice 1995; 9: 312-325
36 Colton RH, Casper JK, Leonard R. Understanding voice problems: a physiological perspective for diagnosis and treatment. 3^rd ed. Philadelphia: Lippincott Williams and Wilkins; 2005
37 Hsiung MW. Videolaryngostroboscopic observation of mucus layer during vocal cord vibration in patients with vocal nodules before and after surgery. Acta Otolaryngol 2004; 124: 186-191
38 Schneider B, Bigenzahn W. Stimmdiagnostik – ein Leitfaden für die Praxis. Springer Verlag; Wien, New York: 2007: 1-307
39 Holmberg EB, Hillman RE, Hammarberg B, Södersten M, Doyle P. Efficacy of a behaviorally based voice therapy protocol for vocal nodules. J Voice 2001; 15: 395-412
40 Sulica L, Behrman A. Management of benign vocal fold lesions: a survey of current opinion and practice. Ann Otol Rhinol Laryngol 2003; 112: 827-833
41 Eckel EH, Glanz H, Hess M, Nawka T, Schultz-Coulon HJ. Phoniatry and ENT on: dagnostic and therapeutic problems with organic voice disorders. Laryngorhinootologie 2003; 82: 756-757
42 Leonard R, Kendall K. Effects of voice therapy on vocal process granuloma: a phonoscopic approach. Am J Otolaryngol 2005; 26: 101-107
43 Zhang Y, Jiang JJ. Chaotic vibrations of a vocal fold model with a unilateral polyp. J Acoust Soc Am 2004; 115: 1266-1269
44 Shohet JA, Courey MS, Scott MA, Ossoff RH. Value of videostroboscopic parameters in differentiating true vocal fold cysts from polyps. Laryngoscope 1996; 106: 19-26
45 Cohen SM, Garrett CG. Utility of voice therapy in the management of vocal fold polyps and cysts. Otolaryngol Head Neck Surg 2007; 136: 742-746
46 Bouchayer M, Cornut G, Witzig E, Loire R, Roch JB, Bastian RW. Epidermoid cysts, sulci, and mucosal bridges of the true vocal cord: a report of 157 cases. Laryngoscope 1985; 95: 1087-1094
47 Storck C, Brockmann M, Zimmermann E, Nekahm-Heis D, Zorowka PG. Laryngeal granuloma. Aetiology, clinical signs, diagnostic procedures, and treatment. HNO 2009; 57: 1075-1080
48 Sieron J, Johannsen HS. Contact granuloma: symptoms, etiology, diagnosis, therapy. Laryngorhinootologie 1992; 71: 193-197
49 Farwell DG, Belafsky PC, Rees CJ. An endoscopic grading system for vocal process granuloma. J Laryngol Otol 2008; 122: 1092-1095
50 de Lima Pontes PA, De Biase NG, Gadelha EC. Clinical evolution of laryngeal granulomas: treatment and prognosis. Laryngoscope 1999; 109: 289-294
51 Ylitalo R, Ramel S. Extraesophageal reflux in patients with contact granuloma: a prospective controlled study. Ann Otol Rhinol Laryngol 2002; 111: 441-446
52 Damrose EJ, Damrose JF. Botulinum toxin as adjunctive therapy in refractory laryngeal granuloma. J Laryngol Otol 2008; 122: 824-828
53 Kiese-Himmel C, Kruse E. Sociodemographic variables of a German sample of patients with contact granuloma. J Voice 1995; 9: 449-452
54 Mans EJ, Kühn AG, Lamprecht-Dinnesen A. Psychosomatic findings in patients with contact granuloma – initial results. HNO 1992; 40: 346-351
55 Sun GB, Sun N, Tang HH, Zhu QB, Wen W, Zheng HL. Zinc sulfate therapy of vocal process granuloma. Eur Arch Otorhinolaryngol 2012; 269: 2087-2090
56 Lemos EM, Sennes LU, Imamura R, Tsuji DH. Vocal process granuloma: clinical characterization, treatment and evolution. Braz J Otorhinolaryngol 2005; 71: 494-498
57 Hillel AT, Lin LM, Samlan R, Starmer H, Leahy K, Flint PW. Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas: a series of 67 granulomas. Ann Otol Rhinol Laryngol 2010; 119: 325-330
58 Carroll TL, Gartner-Schmidt J, Statham MM, Rosen CA. Vocal process granuloma and glottal insufficiency: an overlooked etiology?. Laryngoscope 2010; 120: 114-120
59 Hirano S, Kojima H, Tateya I, Ito J. Fiberoptic laryngeal surgery for vocal process granuloma. Ann Otol Rhinol Laryngol 2002; 111: 789-793
60 Benjamin B, Croxson G. Vocal cord granulomas. Ann Otol Rhinol Laryngol 1985; 94: 538-541
61 Wang CP, Ko JY, Wang YH, Hu YL, Hsiao TY. Vocal process granuloma – A result of long-term observation in 53 patients. Oral Oncol 2009; 45: 821-825
62 Derkay CS. Task force on recurrent respiratory papillomas. A preliminary report. Arch Otolaryngol Head Neck Surg 1995; 121: 1386-1391
63 Derkay CS, Wiatrak B. Recurrent respiratory papillomatosis: a review. Laryngoscope 2008; 118: 1236-1247
64 Armstrong LR, Derkay CS, Reeves WC. Initial results from the national registry for juvenile-onset recurrent respiratory papillomatosis. RRP Task Force. Arch Otolaryngol Head Neck Surg 1999; 125: 743-748
65 Reeves WC, Ruparelia SS, Swanson KI, Derkay CS, Marcus A, Unger ER. National registry for juvenile-onset recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 2003; 129: 976-982
66 Kashima H, Mounts P, Leventhal B, Hruban RH. Sites of predilection in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol 1993; 102: 580
67 Schraff S, Derkay CS, Burke B, Lawson L. American Society of Pediatric Otolaryngology members’ experience with recurrent respiratory papillomatosis and the use of adjuvant therapy. Arch Otolaryngol Head Neck Surg 2004; 130: 1039-1042
68 Xue Q, Wang H, Wang J. Recurrent respiratory papillomatosis: an overview. Eur J Clin Microbiol Infect Dis 2010; 29: 1051-1054
69 Ruparelia S, Unger ER, Nisenbaum R, Derkay CS, Reeves WC. Predictors of remission in juvenile-onset recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 2003; 129: 1275-1278
70 Draganov P, Todorov S, Todorov I, Karchev T, Kalvatchev Z. Identification of HPV DNA in patients with juvenile-onset recurrent respiratory papillomatosis using SYBR Green real-time PCR. Int J Pediatr Otorhinolaryngol 2006; 70: 469-473
71 Morshed K, Polz-Dacewicz M, Szymański M, Polz D. Short-fragment PCR assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation. Eur Arch Otorhinolaryngol 2008; 265: 89-96
72 Mammas IN, Sourvinos G, Zaravinos A, Spandidos DA. Vaccination against human papilloma virus: epidemiological evidence of HPV in non-genital cancers. Pathol Oncol Res 2011; 17: 103-119
73 Azzimonti B, Pagano M, Mondini M, De Andrea M, Valente G, Monga G, Tommasino M, Aluffi P, Landolfo S, Gariglio M. Altered patterns of the interferon-inducible gene IFI16 expression in head and neck squamous cell carcinoma: immunohistochemical study including correlation with retinoblastoma protein, human papillomavirus infection and proliferation index. Histopathology Dec 2004; 45: 560-572
74 Lee LA, Cheng AJ, Fang TJ, Huang CG, Liao CT, Chang JT, Li HY. High incidence of malignant transformation of laryngeal papilloma in Taiwan. Laryngoscope 2008; 118: 50-55
75 Wiatrak BJ, Wiatrak DW, Broker TR, Lewis L. Recurrent respiratory papillomatosis: a longitudinal study comparing severity associated with human papilloma viral types 6 and 11 and other risk factors in a large pediatric population. Laryngoscope 2004; 114 1-23
76 Torrente MC, Rodrigo JP, Haigentz Jr M, Dikkers FG, Rinaldo A, Takes RP, Olofsson J, Ferlito A. Human papillomavirus infections in laryngeal cancer. Head Neck 2011; 33: 581-586
77 Silverberg MJ, Thorsen P, Lindeberg H, Grant LA, Shah KV. Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol 2003; 101: 645-652
78 Shah K, Kashima H, Polk BF, Shah F, Abbey H, Abramson A. Rarity of cesarean delivery in cases of juvenile-onset respiratory papillomatosis. Obstet Gynecol 1986; 68: 795-799
79 Bishai D, Kashima H, Shah K. The cost of juvenile-onset recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 2000; 126: 935-939
80 Stamataki S, Nikolopoulos TP, Korres S, Felekis D, Tzangaroulakis A, Ferekidis E. Juvenile recurrent respiratory papillomatosis: still a mystery disease with difficult management. Head Neck 2007; 29: 155-162
81 Larson DA, Derkay CS. Epidemiology of recurrent respiratory papillomatosis. APMIS 2010; 118: 450-454
82 Andratschke M, Betz C, Leunig A. Laryngeal papillomatosis: etiology, diagnostics and therapy. HNO 2008; 56: 1190-1196
83 Gerein V, Soldatski IL, Babkina N, Onufrieva EK, Barysik N, Pfister H. Children and partners of patients with recurrent respiratory papillomatosis have no evidence of the disease during long-term observation. Int J Pediatr Otorhinolaryngol 2006; 70: 2061-2066
84 Lee JH, Smith RJ. Recurrent respiratory papillomatosis: pathogenesis to treatment. Curr Opin Otolaryngol Head Neck Surg 2005; 13: 354-359
85 Smith EM, Pignatari SS, Gray SD, Haugen TH, Turek LP. Human papillomavirus infection in papillomas and nondiseased respiratory sites of patients with recurrent respiratory papillomatosis using the polymerase chain reaction. Arch Otolaryngol Head Neck Surg 1993; 119: 554-557
86 Stern Y, Felipovich A, Cotton RT, Segal K. Immunocompetency in children with recurrent respiratory papillomatosis: prospective study. Ann Otol Rhinol Laryngol 2007; 116: 169-171
87 McKenna M, Brodsky L. Extraesophageal acid reflux and recurrent respiratory papilloma in children. Int J Pediatr Otorhinolaryngol 2005; 69: 597-605
88 DeFatta RA, Sataloff JB, Klaris GE, Sataloff RT. Laryngeal papilloma. Ear Nose Throat J 2012; 91: 21-22
89 Bielecki I, Mniszek J, Cofała M. Intralesional injection of cidofovir for recurrent respiratory papillomatosis in children. Int J Pediatr Otorhinolaryngol 2009; 73: 681-684
90 Lott DG, Krakovitz PR. Squamous cell carcinoma associated with intralesional injection of cidofovir for recurrent respiratory papillomatosis. Laryngoscope 2009; 119: 567-570
91 Malagón T, Drolet M, Boily MC, Franco EL, Jit M, Brisson J, Brisson M. Cross-protective efficacy of two human papillomavirus vaccines: a systematic review and meta-analysis. Lancet Infect Dis 2012; Aug 21. [Epub ahead of print]
92 Jeyakumar A, Mitchell R. HPV vaccination and recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 2011; 144: 133
93 Pawlita M, Gissmann L. Recurrent respiratory papillomatosis: indication for HPV vaccination?. Dtsch Med Wochenschr 2009; 134: 100-102
94 Reisinger KS, Block SL, Lazcano-Ponce E, Samakoses R, Esser MT, Erick J, Puchalski D, Giacoletti KE, Sings HL, Lukac S, Alvarez FB, Barr E. Safety and persistent immunogenicity of a quadrivalent human papillomavirus types 6, 11, 16, 18 L1 virus-like particle vaccine in preadolescents and adolescents: a randomized controlled trial. Pediatr Infect Dis J 2007; 26: 201-209
95 Mudry P, Vavrina M, Mazanek P, Machalova M, Litzman J, Sterba J. Recurrent laryngeal papillomatosis: successful treatment with human papillomavirus vaccination. Arch Dis Child 2011; 96: 476-477
96 Förster G, Boltze C, Seidel J, Pawlita M, Müller A. Juvenile laryngeal papillomatosis – immunisation with the polyvalent vaccine gardasil. Laryngorhinootologie 2008; 87: 796-799
97 Freed GL, Derkay CS. Prevention of recurrent respiratory papillomatosis: role of HPV vaccination. Int J Pediatr Otorhinolaryngol 2006; 70: 1799-1803
98 Desloge RB, Zeitels SM. Endolaryngeal microsurgery at the anterior glottal commissure: controversies and observations. Ann Otol Rhinol Laryngol 2000; 109: 385-392