Neuroimaging of the Afferent Visual System

Robert M. Mallery; Sashank Prasad

doi:10.1055/s-0032-1331805

Seminars in Neurology, Table of Contents

Semin Neurol 2012; 32(04): 273-319
DOI: 10.1055/s-0032-1331805

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neuroimaging of the Afferent Visual System

Robert M. Mallery

¹Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts

,

Sashank Prasad

¹Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts

› Author Affiliations

Abstract

Neuroimaging studies provide a useful tool for the clinician evaluating a patient with visual loss. In this review, we discuss the use of magnetic resonance imaging (MRI), computed tomography (CT), orbital ultrasound, and optical coherence tomography (OCT) for evaluating causes of visual loss affecting the afferent visual system. The imaging characteristics of diseases affecting the optic nerve, orbit, sellar and parasellar region, optic tracts, and retrogeniculate visual pathways will be discussed.

Keywords

neuroimaging - neuro-ophthalmology - visual loss - optical coherence tomography (OCT) - ultrasound

Full Text

References

References
1 Miller N. Walsh and Hoyt's Clinical Neuro-Ophthalmology. 4th ed. Baltimore, MD: Waverly Press; 1982
2 Maniscalco JE, Habal MB. Microanatomy of the optic canal. J Neurosurg 1978; 48 (3) 402-406
3 Liu GT, Volpe NJ, Galetta SL. Neuro-Ophthalmology: Diagnosis and Management. 2nd ed. Philadelphia, PA: Saunders Elsevier; 2010
4 Becker M, Masterson K, Delavelle J, Viallon M, Vargas MI, Becker CD. Imaging of the optic nerve. Eur J Radiol 2010; 74 (2) 299-313
5 Hickman SJ, Wheeler-Kingshott CA, Jones SJ , et al. Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis. AJNR Am J Neuroradiol 2005; 26 (4) 951-956
6 Wheeler-Kingshott CA, Trip SA, Symms MR, Parker GJ, Barker GJ, Miller DH. In vivo diffusion tensor imaging of the human optic nerve: pilot study in normal controls. Magn Reson Med 2006; 56 (2) 446-451
7 Trip SA, Wheeler-Kingshott C, Jones SJ , et al. Optic nerve diffusion tensor imaging in optic neuritis. Neuroimage 2006; 30 (2) 498-505
8 Kiernan DF, Mieler WF, Hariprasad SM. Spectral-domain optical coherence tomography: a comparison of modern high-resolution retinal imaging systems. Am J Ophthalmol 2010; 149 (1) 18-31
9 Mirza RG, Johnson MW, Jampol LM. Optical coherence tomography use in evaluation of the vitreoretinal interface: a review. Surv Ophthalmol 2007; 52 (4) 397-421
10 Lee KM, Woo SJ, Hwang JM. Differentiation of optic nerve head drusen and optic disc edema with spectral-domain optical coherence tomography. Ophthalmology 2011; 118 (5) 971-977
11 Heidary G, Rizzo III JF. Use of optical coherence tomography to evaluate papilledema and pseudopapilledema. Semin Ophthalmol 2010; 25 (5–6) 198-205
12 Walter SD, Ishikawa H, Galetta KM , et al. Ganglion cell loss in relation to visual disability in multiple sclerosis. Ophthalmology 2012; 119 (6) 1250-1257
13 Dees C, Buimer R, Dick AD, Atta HR. Ultrasonographic investigation of optic neuritis. Eye (Lond) 1995; 9 (Pt 4) 488-494
14 Optic Neuritis Study Group. The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Arch Ophthalmol 1991; 109 (12) 1673-1678
15 Beck RW, Cleary PA, Anderson Jr MM , et al; The Optic Neuritis Study Group. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. N Engl J Med 1992; 326 (9) 581-588
16 Miller DH, Johnson G, McDonald WI , et al. Detection of optic nerve lesions in optic neuritis with magnetic resonance imaging. Lancet 1986; 1 (8496) 1490-1491
17 Fazzone HE, Lefton DR, Kupersmith MJ. Optic neuritis: correlation of pain and magnetic resonance imaging. Ophthalmology 2003; 110 (8) 1646-1649
18 Optic Neuritis Study Group. Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. Arch Neurol 2008; 65 (6) 727-732
19 McDonald WI, Compston A, Edan G , et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 2001; 50 (1) 121-127
20 Polman CH, Reingold SC, Banwell B , et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69 (2) 292-302
21 Montalban X, Tintoré M, Swanton J , et al. MRI criteria for MS in patients with clinically isolated syndromes. Neurology 2010; 74 (5) 427-434
22 Swanton JK, Rovira A, Tintore M , et al. MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study. Lancet Neurol 2007; 6 (8) 677-686
23 Morrow MJ, Wingerchuk D. Neuromyelitis optica. J Neuroophthalmol 2012; 32 (2) 154-166
24 Pittock SJ, Lennon VA, Krecke K, Wingerchuk DM, Lucchinetti CF, Weinshenker BG. Brain abnormalities in neuromyelitis optica. Arch Neurol 2006; 63 (3) 390-396
25 Jabs DA, Johns CJ. Ocular involvement in chronic sarcoidosis. Am J Ophthalmol 1986; 102 (3) 297-301
26 Koczman JJ, Rouleau J, Gaunt M, Kardon RH, Wall M, Lee AG. Neuro-ophthalmic sarcoidosis: the University of Iowa experience. Semin Ophthalmol 2008; 23 (3) 157-168
27 Frohman LP, Guirgis M, Turbin RE, Bielory L. Sarcoidosis of the anterior visual pathway: 24 new cases. J Neuroophthalmol 2003; 23 (3) 190-197
28 Braun JJ, Kessler R, Constantinesco A, Imperiale A. 18F-FDG PET/CT in sarcoidosis management: review and report of 20 cases. Eur J Nucl Med Mol Imaging 2008; 35 (8) 1537-1543
29 Kidd D, Burton B, Plant GT, Graham EM. Chronic relapsing inflammatory optic neuropathy (CRION). Brain 2003; 126 (Pt 2) 276-284
30 March Jr GA, Lessell S. Infectious optic neuropathy. Int Ophthalmol Clin 1996; 36 (3) 197-205
31 Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the Ischemic Optic Neuropathy Decompression Trial. Arch Ophthalmol 1996; 114 (11) 1366-1374
32 Rizzo III JF, Andreoli CM, Rabinov JD. Use of magnetic resonance imaging to differentiate optic neuritis and nonarteritic anterior ischemic optic neuropathy. Ophthalmology 2002; 109 (9) 1679-1684
33 He M, Cestari D, Cunnane MB, Rizzo III JF. The use of diffusion MRI in ischemic optic neuropathy and optic neuritis. Semin Ophthalmol 2010; 25 (5-6) 225-232
34 Kattah JC, Mejico L, Chrousos GA, Zimmerman LE, Manz HJ. Pathologic findings in a steroid-responsive optic nerve infarct in giant-cell arteritis. Neurology 1999; 53 (1) 177-180
35 Lee AG, Eggenberger ER, Kaufman DI, Manrique C. Optic nerve enhancement on magnetic resonance imaging in arteritic ischemic optic neuropathy. J Neuroophthalmol 1999; 19 (4) 235-237
36 Avery RA, Fisher MJ, Liu GT. Optic pathway gliomas. J Neuroophthalmol 2011; 31 (3) 269-278
37 Listernick R, Charrow J. Neurofibromatosis type 1 in childhood. J Pediatr 1990; 116 (6) 845-853
38 Listernick R, Charrow J, Greenwald M, Mets M. Natural history of optic pathway tumors in children with neurofibromatosis type 1: a longitudinal study. J Pediatr 1994; 125 (1) 63-66
39 Brodsky MC. The “pseudo-CSF” signal of orbital optic glioma on magnetic resonance imaging: a signature of neurofibromatosis. Surv Ophthalmol 1993; 38 (2) 213-218
40 Saeed P, Rootman J, Nugent RA, White VA, Mackenzie IR, Koornneef L. Optic nerve sheath meningiomas. Ophthalmology 2003; 110 (10) 2019-2030
41 Miller NR. New concepts in the diagnosis and management of optic nerve sheath meningioma. J Neuroophthalmol 2006; 26 (3) 200-208
42 Steinsapir KD, Goldberg RA. Traumatic optic neuropathy. Surv Ophthalmol 1994; 38 (6) 487-518
43 Sarkies N. Traumatic optic neuropathy. Eye (Lond) 2004; 18 (11) 1122-1125
44 Anderson RL, Panje WR, Gross CE. Optic nerve blindness following blunt forehead trauma. Ophthalmology 1982; 89 (5) 445-455
45 Lessell S. Indirect optic nerve trauma. Arch Ophthalmol 1989; 107 (3) 382-386
46 McGonigal A, Bone I, Teasdale E. Resolution of transverse sinus stenosis in idiopathic intracranial hypertension after L-P shunt. Neurology 2004; 62 (3) 514-515
47 Baryshnik DB, Farb RI. Changes in the appearance of venous sinuses after treatment of disordered intracranial pressure. Neurology 2004; 62 (8) 1445-1446
48 Higgins JN, Pickard JD. Lateral sinus stenoses in idiopathic intracranial hypertension resolving after CSF diversion. Neurology 2004; 62 (10) 1907-1908
49 Wang JK, Kardon RH, Kupersmith MJ, Garvin MK. Automated quantification of volumetric optic disc swelling in papilledema using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci 2012; 53 (7) 4069-4075
50 Kurz-Levin MM, Landau K. A comparison of imaging techniques for diagnosing drusen of the optic nerve head. Arch Ophthalmol 1999; 117 (8) 1045-1049
51 Dallow RL, Pratt SG, Green JP. Approach to orbital disorders and frequency of disease occurrence. In: Albert DM, Jakobiec FA, , eds. Principles and Practice of Ophthalmology. 2nd ed. Philadelphia, PA: WB Saunders; 1996: 3056-3067
52 Neigel JM, Rootman J, Belkin RI , et al. Dysthyroid optic neuropathy. The crowded orbital apex syndrome. Ophthalmology 1988; 95 (11) 1515-1521
53 Bartley GB, Fatourechi V, Kadrmas EF , et al. Clinical features of Graves' ophthalmopathy in an incidence cohort. Am J Ophthalmol 1996; 121 (3) 284-290
54 Hoh HB, Laitt RD, Wakeley C , et al. The STIR sequence MRI in the assessment of extraocular muscles in thyroid eye disease. Eye (Lond) 1994; 8 (Pt 5) 506-510
55 Mayer E, Herdman G, Burnett C, Kabala J, Goddard P, Potts MJ. Serial STIR magnetic resonance imaging correlates with clinical score of activity in thyroid disease. Eye (Lond) 2001; 15 (Pt 3) 313-318
56 Margo CE, Mulla ZD. Malignant tumors of the orbit. Analysis of the Florida Cancer Registry. Ophthalmology 1998; 105 (1) 185-190
57 Moon WJ, Na DG, Ryoo JW , et al. Orbital lymphoma and subacute or chronic inflammatory pseudotumor: differentiation with two-phase helical computed tomography. J Comput Assist Tomogr 2003; 27 (4) 510-516
58 Akansel G, Hendrix L, Erickson BA , et al. MRI patterns in orbital malignant lymphoma and atypical lymphocytic infiltrates. Eur J Radiol 2005; 53 (2) 175-181
59 Priego G, Majos C, Climent F, Muntane A. Orbital lymphoma: imaging features and differential diagnosis. Insights Imaging 2012; 3 (4) 337-344
60 Eustis HS, Mafee MF, Walton C, Mondonca J. MR imaging and CT of orbital infections and complications in acute rhinosinusitis. Radiol Clin North Am 1998; 36 (6) 1165-1183, xi
61 Kapur R, Sepahdari AR, Mafee MF , et al. MR imaging of orbital inflammatory syndrome, orbital cellulitis, and orbital lymphoid lesions: the role of diffusion-weighted imaging. AJNR Am J Neuroradiol 2009; 30 (1) 64-70
62 Pakrou N, Selva D, Leibovitch I. Wegener's granulomatosis: ophthalmic manifestations and management. Semin Arthritis Rheum 2006; 35 (5) 284-292
63 Sadiq SA, Jennings CR, Jones NS, Downes RN. Wegener's granulomatosis: The ocular manifestations revisited. Orbit 2000; 19 (4) 253-261
64 Talar-Williams C, Sneller MC, Langford CA, Smith JA, Cox TA, Robinson MR. Orbital socket contracture: a complication of inflammatory orbital disease in patients with Wegener's granulomatosis. Br J Ophthalmol 2005; 89 (4) 493-497
65 Lohrmann C, Uhl M, Warnatz K, Kotter E, Ghanem N, Langer M. Sinonasal computed tomography in patients with Wegener's granulomatosis. J Comput Assist Tomogr 2006; 30 (1) 122-125
66 Muhle C, Reinhold-Keller E, Richter C , et al. MRI of the nasal cavity, the paranasal sinuses and orbits in Wegener's granulomatosis. Eur Radiol 1997; 7 (4) 566-570
67 Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology 2004; 111 (5) 997-1008
68 Char DH, Miller T, Kroll S. Orbital metastases: diagnosis and course. Br J Ophthalmol 1997; 81 (5) 386-390
69 Valenzuela AA, Archibald CW, Fleming B , et al. Orbital metastasis: clinical features, management and outcome. Orbit 2009; 28 (2-3) 153-159
70 Xian J, Zhang Z, Wang Z , et al. Evaluation of MR imaging findings differentiating cavernous haemangiomas from schwannomas in the orbit. Eur Radiol 2010; 20 (9) 2221-2228
71 Kransdorf MJ, Moser Jr RP, Gilkey FW. Fibrous dysplasia. Radiographics 1990; 10 (3) 519-537
72 Lisle DA, Monsour PA, Maskiell CD. Imaging of craniofacial fibrous dysplasia. J Med Imaging Radiat Oncol 2008; 52 (4) 325-332
73 Choi SH, Kwon BJ, Na DG, Kim JH, Han MH, Chang KH. Pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions: differentiation using MRI. Clin Radiol 2007; 62 (5) 453-462
74 Cottier JP, Destrieux C, Brunereau L , et al. Cavernous sinus invasion by pituitary adenoma: MR imaging. Radiology 2000; 215 (2) 463-469
75 Hershey BL. Suprasellar masses: diagnosis and differential diagnosis. Semin Ultrasound CT MR 1993; 14 (3) 215-231
76 Voelker JL, Campbell RL, Muller J. Clinical, radiographic, and pathological features of symptomatic Rathke's cleft cysts. J Neurosurg 1991; 74 (4) 535-544
77 Wilson WB. Meningiomas of the anterior visual system. Surv Ophthalmol 1981; 26 (3) 109-127
78 Kinjo T, al-Mefty O, Ciric I. Diaphragma sellae meningiomas. Neurosurgery 1995; 36 (6) 1082-1092
79 Rao VJ, James RA, Mitra D. Imaging characteristics of common suprasellar lesions with emphasis on MRI findings. Clin Radiol 2008; 63 (8) 939-947
80 Fassett DR, Couldwell WT. Metastases to the pituitary gland. Neurosurg Focus 2004; 16 (4) E8
81 Newman NJ, Lessell S, Winterkorn JM. Optic chiasmal neuritis. Neurology 1991; 41 (8) 1203-1210
82 Neau JP, Bogousslavsky J. The syndrome of posterior choroidal artery territory infarction. Ann Neurol 1996; 39 (6) 779-788
83 Osborne BJ, Liu GT, Galetta SL. Geniculate quadruple sectoranopia. Neurology 2006; 66 (11) E41-E42
84 Horton JC, Landau K, Maeder P, Hoyt WF. Magnetic resonance imaging of the human lateral geniculate body. Arch Neurol 1990; 47 (11) 1201-1206
85 Zhang X, Kedar S, Lynn MJ, Newman NJ, Biousse V. Homonymous hemianopia in stroke. J Neuroophthalmol 2006; 26 (3) 180-183
86 Gauvrit JY, Leclerc X, Girot M , et al. Fluid-attenuated inversion recovery (FLAIR) sequences for the assessment of acute stroke: inter observer and inter technique reproducibility. J Neurol 2006; 253 (5) 631-635
87 Thomalla G, Cheng B, Ebinger M , et al; STIR and VISTA Imaging Investigators. DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol 2011; 10 (11) 978-986
88 Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 2001; 56 (4) 537-539
89 Linn J, Halpin A, Demaerel P , et al. Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. Neurology 2010; 74 (17) 1346-1350
90 Hengel K, Sidhu G, Choi J , et al. Attributes of brain metastases from breast and lung cancer. Int J Clin Oncol 2012;
91 Kiriyama T, Kataoka H, Taoka T , et al. Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm. J Neuroimaging 2011; 21 (2) e69-e77
92 Feske SK. Posterior reversible encephalopathy syndrome: a review. Semin Neurol 2011; 31 (2) 202-215
93 Ito H, Mori K, Kagami S. Neuroimaging of stroke-like episodes in MELAS. Brain Dev 2011; 33 (4) 283-288
94 Bi WL, Baehring JM, Lesser RL. Evolution of brain imaging abnormalities in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes. J Neuroophthalmol 2006; 26 (4) 251-256
95 Geschwind N. Disconnexion syndromes in animals and man. I. Brain 1965; 88 (2) 237-294
96 Geschwind N. Disconnexion syndromes in animals and man. II. Brain 1965; 88 (3) 585-644
97 Mendez MF, Mendez MA, Martin R, Smyth KA, Whitehouse PJ. Complex visual disturbances in Alzheimer's disease. Neurology 1990; 40 (3 Pt 1) 439-443
98 Levine DN, Lee JM, Fisher CM. The visual variant of Alzheimer's disease: a clinicopathologic case study. Neurology 1993; 43 (2) 305-313
99 Lee AG, Martin CO. Neuro-ophthalmic findings in the visual variant of Alzheimer's disease. Ophthalmology 2004; 111 (2) 376-380 , discussion 380–381
100 Dejerine J. Contribution of l'étude anatomo-pathologique et clinique des differentes varietiés de cecité verbale. Memoires Societé Biologique 1892; 4: 61-90