This work is dedicated to the late Dr. Uttara Debi who was compassionate and amicable
in nature.
A new approach for the synthesis of multi-functionalized 1,5-benzodiazepines is developed
starting from o-phenylenediamines, β-keto esters and aromatic aldehydes utilizing a one-pot, three-component
strategy employing bromodimethylsulfonium bromide as the catalyst. The simple reaction
procedure, good yields, mild reaction conditions and applicability to a wide range
of substrates are some of the salient features of this protocol.
Key words
multi-component reactions - 1,5-benzodiazepines -
o-phenylenediamines - bromodimethylsulfonium bromide