Study on the Influence of a Sustainable Medium for the Design of Multistep Processes: Three-Component Synthesis of 2-Nitroamines

Abstract

An environmentally benign method was developed for the three-component, one-pot synthesis of 2-nitroamines by heating a solution of an aldehyde, an aromatic amine, and a nitroalkane in 20% water–methanol at 60 °C for five hours in the absence of a catalyst.

Key words

coupling - Mannich bases - multicomponent reactions - Schiff bases - solvent effects

• References

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All 2-nitroamines 5 synthesized are known compounds, see:
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