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Aktuelle Urol 2013; 44(05): 381-382
DOI: 10.1055/s-0033-1345147
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Malignant Bladder Pheochromocytoma with SDHB Genetic Mutation

Malignes Phäochromozytom der Blase mit genetischer SDHB Mutation
M. Maeda
1   Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
Y. Funahashi
1   Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
M. Katoh
1   Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
T. Fujita
1   Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
K. Tsuruta
1   Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
M. Gotoh
1   Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
27 June 2013 (online)

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Abstract

A 30-year-old man presented with micturition pain and was diagnosed with a submucosal tumor in the right wall of the bladder with metastasis to the right obturator lymph node. Transurethral resection led to a diagnosis of invasive malignant pheochromocytoma. Radical cystectomy, neobladder reconstruction and bilateral iliac lymph node dissection were performed. Genetic analysis revealed succinate dehydrogenase B-associated hereditary pheochromocytoma/paraganglioma syndrome. 10 months after the operation, he had no evidence of recurrence.

Zusammenfassung

Ein 30-jähriger Mann stellte sich mit Miktions­schmerz vor. Es wurde ein submukosaler Tumor in der rechten Blasenwand mit Metastasierung in die rechten Obturator-Lymphknoten diagnostiziert. Die transurethrale Tumorresektion ergab die Diagnose eines invasiven malignen Phäochromozytoms. In Folge wurden eine radikale Zystektomie, eine Neoblasen-Rekonstruktion und bilaterale iliakale Lymphknoten Dissektionen durchgeführt. Die genetische Analyse zeigte ein Succinatdehydrogenase B assoziiertes Phäochromozytom/Paragangliom Syndrom. 10 Monate nach der Operation ergab sich kein Hinweis auf ein Rezidiv.

Key words

malignant pheochromo­cytoma - urinary bladder - hereditary pheochromocytoma/paraganglioma syndrome - SDHB

Schlüsselwörter

malignes Phäochromozytom - Harnblase - hereditäres Phäochromozytom/Paragangliom Syndrom - SDHB
 

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