Gastrointestinale Stromatumoren (GIST)

Gastrointestinale Stromatumoren sind die häufigsten mesenchymalen Tumoren des Gastrointestinaltrakts; ihre Inzidenz beträgt ca. 10–15 pro 1 Million Einwohner und Jahr. Die Geschlechtsverteilung ist nahezu ausgeglichen bei leichtem Überwiegen der Männer. Selten wird eine hereditäre Prädisposition gefunden. Die weit überwiegende Zahl der GIST tritt sporadisch auf.

• Quellenangaben

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• Beham A, Schaefer IM, Cameron S et al. Duodenal GIST: a single center experience. Int J Colorect Dis 2012; 28: 581-590
• Dematteo RP, Ballman KV, Antonescu CR et al. American College of Surgeons Oncology Group (ACOSOG); Intergroup Adjuvant GIST Study Team. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet 2009; 373: 1097-1104
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• Gold JS, Gonen M, Gutierrez A et al. Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis. Lancet Oncol 2009; 10: 1045-1052
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• Joensuu H. Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol 2008; 39: 1411-1419
• Joensuu H, Vehtari A, Riihimaki J et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol 2012; a 13: 265-274
• Joensuu H, Eriksson M, Sundby Hall K et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA 2012; b 307: 1265-1272
• Matthews BD, Walsh RM, Kercher KW et al. Laparoscopic vs open resection of gastric stromal tumors. Surg Endosc 2002; 16: 803-807
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• National Comprehensive Cancer Network. Clinical practice guidelines in oncology: soft tissue sarcoma (version 2.2011). Im Internet:. http://www.nccn.org/professionals/physician_gls/ Stand: 13.11.2013
• Nguyen SQ, Divino CM, Wang JL et al. Laparoscopic management of gastrointestinal stromal tumors. Surg Endosc 2006; 20: 713-716
• Novitsky YW, Kercher KW, Sing RF et al. Long-term outcomes of laparoscopic resection of gastric gastrointestinal stromal tumors. Ann Surg 2006; 243: 738-745
• Pierie JP, Choudry U, Muzikansky A et al. The effect of surgery and grade on outcome of gastrointestinal stromal tumors. Arch Surg 2001; 136: 383-389
• Reichardt P, Schütte J. Gastrointestinale Stromaturmore (GIST). Aktuelle Leitlinie der DGHO (Juni 2011). Im Internet:. http://www.dgho-onkopedia.de/de/onkopedia/leitlinien/gastrointestinale-stromatumore-gist Stand: 13.11.2013
• Rutkowski P, Nowecki ZI, Michej W et al. Risk criteria and prognostic factors for predicting recurrences after resection of primary gastrointestinal stromal tumor. Ann Surg Oncol 2007; 14: 2018-2027

• Zum Weiterlesen und Vertiefen

• Demetri GD, Reichardt P, Kang YK et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013; 381: 295-302
• Joensuu H, Vehtari A, Riihimaki J et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol 2012; a 13: 265-274
• Joensuu H, Eriksson M, Sundby Hall K et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA 2012; b 307: 1265-1272
• Reichardt P, Schütte J. Gastrointestinale Stromaturmore (GIST). Aktuelle Leitlinie der DGHO (Juni 2011). Im Internet:. http://www.dgho-onkopedia.de/de/onkopedia/leitlinien/gastrointestinale-stromatumore-gist Stand: 13.11.2013