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Horm Metab Res 2014; 46(01): 41-47
DOI: 10.1055/s-0033-1353198
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Different Associations of Adipokines in Lean and Healthy Adults

T. Ebert   *
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
2   IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany
,
I. Roth   *
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
,
J. Richter
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
2   IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany
,
A. Tönjes
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
2   IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany
,
S. Kralisch
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
2   IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany
,
U. Lossner
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
2   IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany
,
J. Kratzsch
3   Institute of Laboratory Medicine, University of Leipzig, Leipzig, Germany
,
M. Blüher
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
,
M. Stumvoll
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
,
M. Fasshauer
1   Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
2   IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany
› Author Affiliations
Further Information

Publication History

received 25 February 2013

accepted 25 July 2013

Publication Date:
16 September 2013 (online)

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Abstract

Regulation of adipokines in lean adults without metabolic disease and without eating disorders has not been comprehensively elucidated. We hypothesized that some of the established associations of these adipocyte-secreted proteins with anthropometric and biochemical measures of glucose homeostasis, lipid metabolism, renal function, as well as inflammation, differ in healthy and low weight adults as compared to overweight/obese patients. Eighty-one subjects with a body mass-index below 22.0 kg/m2 and without malnutrition or eating disorders, as well as fifty overweight/obese patients, were recruited for the study. Serum concentrations of seven adipokines (adiponectin, leptin, adipocyte fatty acid-binding protein [AFABP], chemerin, fibroblast growth factor [FGF]-21, resistin, retinol-binding protein [RBP]-4) were measured by enzyme-linked immunosorbent assays. Lean probands had significantly higher levels of adiponectin and resistin, as well as lower levels of leptin, AFABP, and RBP-4, as compared to overweight/obese subjects. Serum concentrations of adiponectin, leptin, AFABP, chemerin, and resistin were significantly higher in lean women as compared to men (p<0.05). In lean subjects, fasting insulin independently predicted leptin and resistin concentrations. Furthermore, C-reactive protein was independently associated with circulating AFABP and chemerin. Moreover, lean body mass was an independent predictor of leptin, fat mass predicted AFABP levels, whereas RBP-4 was independently correlated to age and triglycerides. In addition, high density lipoprotein cholesterol predicted AFABP. Our results support the notion that several of these adipokines are regulated in a different manner in lean adults as compared to overweight/obese subjects and patients with eating disorders.

Key words

adipokines - leanness - metabolism

* These authors contributed equally to this work.


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    for this article is available online at http://www.thieme-connect.de/ejournals/toc/hmr
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