Drug Research, Table of Contents Drug Res (Stuttg) 2014; 64(05): 240-245DOI: 10.1055/s-0033-1357127 Original Article © Georg Thieme Verlag KG Stuttgart · New YorkSynthesis, Antimicrobial Evaluation and QSAR Studies of 2-hydroxy Propanoic Acid Derivatives Authors Author Affiliations A. Bansal 1 Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India P. Kumar 1 Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India B. Narasimhan 1 Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India Recommend Article Abstract Buy Article(opens in new window) Abstract A series of 2-hydroxypropanoic acid derivatives (1–26) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for their in vitro antimicrobial potential and the results indicated that compounds 5 and 12 were found to be the most potent antimicrobial agents having pMICam values 1.67 and 1.64 µM/ml respectively. QSAR studies indicated the importance of topological parameter, Kier’s valance second order molecular connectivity index (2χv) in describing the antimicrobial activities of synthesized 2-hydroxypropanoic acid derivatives. Key words Key wordsantibacterial - antifungal - synthesis - QSAR Full Text References References 1 Malhotra M, Sharma S, Deep A. Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid. Med Chem Res 2012; 21: 1237-1244 2 Radic GP, Glodovic VV, Ratkovic ZR et al. Synthesis, characterization and antimicrobial activity of novel platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N′-di-3-propanoic acid – Crystal structure of H2-1,2-DPheDDP · 2HCl · H2O. J Mol Struct 2012; 1029: 180-186 3 Sigroha S, Narasimhan B, Kumar P et al. Design, synthesis, antimicrobial, anticancer evaluation, and QSAR studies of 4-(substituted benzylidene-amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-ones. Med Chem Res 2012; 21: 3863-3875 4 Kumar P, Narasimhan B, Sharma D. Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis. ARKIVOC 2008; (xiii): 159-178 5 Judge V, Narasimhan B, Ahuja M et al. Hansch analysis for the prediction of antimycobacterial activity of ofloxacin derivatives. Med Chem Res 2011; 20: 826-837 6 Hansch C, Fujita T. p-σ-π Analysis. A method for the correlation of biological activity and chemical structure. J Am Chem Soc 1964; 86: 1616-1626 7 Golbraikh A, Tropsha A. Beware of q2!. J Mol Graphics Model 2002; 20: 269-276 8 Cappucino JG, Sherman N. Microbiology a laboratory manual. Addison Wesley; California: 1999: 263
