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neuroreha 2013; 05(04): 154-159
DOI: 10.1055/s-0033-1363034
Schwerpunkt Schlucken
Georg Thieme Verlag KG Stuttgart · New York

Darstellung der zerebralen Steuerung des Schluckens

Martin Lotze
1   Universität Greifswald, Walther-Rathenau-Straße 46, 17475 Greifswald
,
Glad Mihai
,
Gabriele Seggewies
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
04. Dezember 2013 (online)

    Lizenzen und Reprints

Zusammenfassung

Nach einem Schlaganfall kommt es häufig zu Schluckstörungen, die in der Akutphase selten erkannt werden, doch für die Patienten lebensbedrohlich sein können. Wissenschaftler versuchen, mithilfe funktioneller Bildgebung das Rätsel der Schluckstörungen zu lüften – ein schwieriges Unterfangen bei aspirationsgefährdeten Patienten. Das Ziel der Forschung ist die gleichzeitige Darstellung der anatomischen Vorgänge sowie die zerebrale Repräsentation, um veränderte Schluckprozesse schon in der Akutphase zu erkennen und die passende Therapie einzuleiten.

 

  • Literatur

  • 1 Aviv JE. Prospective, randomized outcome study of endoscopy versus modified barium swallow in patients with dysphagia. Laryngoscope 2000; 110: 563-574
    Google Scholar
  • 2 Birn RM, Bandettini PA, Cox RW et al. Event-related fMRI of tasks involving brief motion. Hum. Brain Mapp 1999; 7: 106-114
    CrossrefGoogle Scholar
  • 3 Bisch EM, Logemann JA, Rademaker AW et al. Pharyngeal effects of bolus volume, viscosity, and temperature in patients with dysphagia resulting from neurologic impairment and in normal subjects. J Speech Hear Res 1994; 37: 1041-1059
    Google Scholar
  • 4 Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982; 14: 377-381
    PubMedGoogle Scholar
  • 5 Cola MG, Daniels SK, Corey DM et al. Relevance of subcortical stroke in dysphagia. Stroke 2010; 41: 482-486
    CrossrefGoogle Scholar
  • 6 Daniels S, Huckabee ML. Dysphagia following stroke. Plural Publishing; 2008: 149-158
    Google Scholar
  • 7 Daniels SK, Brailey K, Priestly DH et al. Aspiration in patients with acute stroke. Arch Phys Med Rehabil 1998; 79: 14-19
    CrossrefPubMedGoogle Scholar
  • 8 Doty RW, Bosma JF. An electromyographic analysis of reflex deglutition. J Neurophysiol 1956; 19: 44-60
    Google Scholar
  • 9 Foki T, Geissler A, Gartus A et al. Cortical lateralization of bilateral symmetric chin movements and clinical relevance in tumor patients – a high field BOLD-FMRI study. NeuroImage 2007; 37: 26-39
    CrossrefGoogle Scholar
  • 10 Fraser C, Power M, Hamdy S et al. Driving plasticity in human adult motor cortex is associated with improved motor function after brain injury. Neuron 2002; 34: 831-840
    CrossrefGoogle Scholar
  • 11 Hamdy S, Aziz Q, Rothwell JC et al. Explaining oropharyngeal dysphagia after unilateral hemispheric stroke. Lancet 1997; 350: 686-692
    CrossrefGoogle Scholar
  • 12 Hamdy S, Rothwell JC, Brooks DJ et al. Identification of the cerebral loci processing human swallowing with H2(15)O PET activation. J Neurophysiol 1999; a 81: 1917-1926
    Google Scholar
  • 13 Hamdy S, Mikulis DJ, Crawley A et al. Cortical activation during human volitional swallowing: an event-related fMRI study. Am J Physiol 1999; b 277: 219-225
    Google Scholar
  • 14 Hartl DM, Kolb F, Bretagne E et al. Cine magnetic resonance imaging with single-shot fast spin echo for evaluation of dysphagia and aspiration. Dysphagia 2006; 21: 156-162
    CrossrefGoogle Scholar
  • 15 Horner J, Buoyer FG, Alberts MJ et al. Dysphagia following brain-stem stroke. Clinical correlates and outcome. Arch Neurol 1991; 48: 1170-1173
    CrossrefPubMedGoogle Scholar
  • 16 Humbert IA, Robbins J. Normal swallowing and functional magnetic resonance imaging: a systematic review. Dysphagia 2007; 22: 266-275
    Google Scholar
  • 17 Humbert IA, Fitzgerald ME, McLare DG et al. Neurophysiology of swallowing: effects of age and bolus type. NeuroImage 2009; 44: 982-991
    CrossrefGoogle Scholar
  • 18 Hummel F, Celnik P, Giraux P et al. Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain 2005; 128 (Pt 3) 490-499
    CrossrefGoogle Scholar
  • 19 Karacay S, Akin E, Sayin MO et al. Real time balanced turbo field echo Cine-MRI in the analysis of deglutition events and transit times. J Oral Rehabil 2006; 33: 646-653
    CrossrefGoogle Scholar
  • 20 Khedr EM, Abo-Elfetoh N, Rothwell JC. Treatment of post-stroke dysphagia with repetitive transcranial magnetic stimulation. Acta Neurol Scand 2009; 119: 155-161
    CrossrefGoogle Scholar
  • 21 Kubina B, Risti D, Weber J et al. Bilateral brainstem activation by thermal stimulation of the face in healthy volunteers. J Neurol 2010; 257: 271-280
    CrossrefGoogle Scholar
  • 22 Lazarus CL, Logemann JA, Gibbons P. Effects of manouvers on swallowing function in a dysphagic oral cancer patient. Head Neck 1993; 15: 419-424
    CrossrefGoogle Scholar
  • 23 Lang IM. Brain stem control of the phases of swallowing. Dysphagia 2009; 24: 333-348
    CrossrefGoogle Scholar
  • 24 Li S, Luo C, Yu B et al. Functional magnetic resonance imaging study on dysphagia after unilateral hemispheric stroke: a preliminary study. J Neurol Neurosurg Psychiatry 2009; 80: 1320-1329
    CrossrefGoogle Scholar
  • 25 Lotze M, Seggewies G, Erb M et al. The representation of articulation in the primary sensorimotor cortex. NeuroReport 2000; 11: 2985-2989
    CrossrefGoogle Scholar
  • 26 Lotze M, Braun C, Birbaumer N et al. Motor learning elicited by voluntary drive. Brain 2003; 126: 866-872
    CrossrefGoogle Scholar
  • 27 Malandraki GA, Sutton BP, Perlman AL et al. Neural activation of swallowing and swallowing-related tasks in healthy young adults: an attempt to separate the components of deglutition. Hum Brain Mapp 2009; 2009: 3209-3226
    Google Scholar
  • 28 Malandraki GA, Sutton BP, Perlman AL et al. Age-related differences in laterality of cortical activations in swallowing. Dysphagia 2010; in press
    Google Scholar
  • 29 Mann G, Hankey GJ, Cameron D et al. Swallowing function after stroke: prognosis and prognostic factors at 6 months. Stroke 1999; 30: 744-748
    CrossrefGoogle Scholar
  • 30 Martin RE, MacIntosh BJ, Smith RC et al. Cerebral areas processing swallowing and tongue movement are overlapping but distinct: a functional magnetic resonance imaging study. J Neurophysiol 2004; 92: 2428-2443
    CrossrefGoogle Scholar
  • 31 Martin R, Barr A, MacIntosh B et al. Cerebral cortical processing of swallowing in older adults. Exp Brain Res 2007; 176: 12-22
    Google Scholar
  • 32 Michou E, Mistry S, Rothwell J et al. Priming pharyngeal motor cortex by repeated paired associative stimulation: implications for dysphagia neurorehabilitation. Neurorehabil Neural Repair 2013; 27: 355-362
    Google Scholar
  • 33 Mochizuki G, Hoque T, Mraz R et al. Challenging the brain: Exploring the link between effort and cortical activation. Brain Res 2009; 130: 9-19
    Google Scholar
  • 34 Mosier K, Bereznaya I. Parallel cortical networks for volitional control of swallowing in humans. Exp. Brain Res 2001; 140: 280-289
    CrossrefGoogle Scholar
  • 35 Prosiegel M. Neurologie von Schluckstörungen. In: Prosiegel M, (Hrsg) Praxisleitfaden Dysphagie. Hygieneplan; 2002. a 1. Auflage 9-46
    Google Scholar
  • 36 Prosiegel M, Heintze M, Wagner-Sonntag E et al. Deglutition disorders in neurological patients. A prospective study of diagnosis, pattern of impairment, therapy and outcome Nervenarzt 2002; b 73: 364-370
    Google Scholar
  • 37 Robbins J, Hamilton JW, Lof GL et al. Oropharyngeal swallowing in normal adults of different ages. Gastroenterology 1992; 103: 823-829
    Google Scholar
  • 38 Robbins J, Coyle J, Rosenbek J et al. Differentiation of normal and abnormal airway protection during swallowing using the penetration-aspiration scale. Dysphagia 1999; 14: 228-232
    Google Scholar
  • 39 Schroeder MF, Daniels SK, McClain M et al. Clinical and cognitive predictors of swallowing recovery in stroke. J Rehabil Res Dev 2006; 43: 301-310
    CrossrefGoogle Scholar
  • 40 Suzuki M, Asada Y, Ito J et al. Activation of cerebellum and basal ganglia on volitional swallowing detected by functional magnetic resonance imaging. Dysphagia 2003; 18: 71-77
    CrossrefGoogle Scholar
  • 41 Toogood JA, Barr AM, Stevens TK et al. Discrete functional contributions of cerebral cortical foci in voluntary swallowing: a functional magnetic resonance imaging (fMRI) „Go, No-Go” study. Exp Brain Res 2005; 161: 81-90
    CrossrefGoogle Scholar
  • 42 Tzourio-Mazoyer N, Landeau B, Papathanassiou D et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage 2002; 15: 273-289
    CrossrefGoogle Scholar
  • 43 Vuilleumier P, Bogousslavsky J, Regli F et al. Infarction of the lower brainstem. Clinical, aetiological and MRI-topographical correlations Brain 1995; 118: 1013-1025
    CrossrefGoogle Scholar
  • 44 Warabi T, Ito T, Kato M et al. Effects of stroke-induced damage to swallow-related areas in the brain on swallowing mechanics of elderly patients. Geriatr Gerontol Int 2008; 8: 234-242
    CrossrefGoogle Scholar
  • 45 Zhang S, Olthoff A, Frahm J. Real-time magnetic resonance imaging of normal swallowing. J Magn Reson Imaging 2012; 35: 1372-1379
    CrossrefGoogle Scholar