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Neuropediatrics 2014; 45(03): 162-168
DOI: 10.1055/s-0033-1363312
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Application of Magnetic Resonance Spectroscopy in Patients with Alternating Hemiplegia of Childhood: Findings on Metabolic Dysfunctions

Wenjing Jiang
1   Department of Neurology, Qilu Hospital of Shandong University, Jinan, China
,
Lin Ma
1   Department of Neurology, Qilu Hospital of Shandong University, Jinan, China
,
Binfeng Du
2   Department of ICU, Qilu Hospital of Shandong University, Jinan, Shandong, China
,
Zhaofu Chi
1   Department of Neurology, Qilu Hospital of Shandong University, Jinan, China
,
Qingshi Zeng
3   Department of Radiology, Qilu Hospital of Shandong University, Jinan, China
,
Peiyan Shan
1   Department of Neurology, Qilu Hospital of Shandong University, Jinan, China
› Author Affiliations
Further Information

Publication History

13 December 2011

09 October 2013

Publication Date:
19 December 2013 (online)

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Abstract

Objective Alternating hemiplegia of childhood (AHC) is a rare neurodevelopmental syndrome of uncertain etiology. Although the use of magnetic resonance spectroscopy (MRS) for the study of neurologic diseases has grown rapidly over the past decade, its use for AHC patients is quite new. This study was aimed at investigating changes of brain metabolites in patients with alternating hemiplegia of childhood (AHC) during the hemiplegic ictal phases and interictal phases by proton magnetic resonance spectroscopy (1H-MRS).

Methods 1H-MRS was used in AHC patients during the hemiplegic ictal phases and interictal phases to evaluate functional activity in certain brain regions. A total of 10 unmedicated, healthy volunteers served as controls.

Results N-acetylaspartate (NAA)/Creatine(Cr) ratio of the frontal lobes, basal ganglia, and temporal lobes in contralateral hemiplegic hemisphere of AHC patients during the ictal phases was significantly lower than that in AHC patients during interictal phases and control subjects. Significantly increased choline-containing compounds (Cho)/Cr were obtained in corresponding regions.

Conclusions These findings suggest neuronal metabolic dysfunctions in frontal lobes, temporal lobes and basal ganglia in AHC patients during ictal phases that perhaps are involved in the pathogenesis of AHC.

Keywords

alternating hemiplegia - childhood - magnetic resonance spectroscopy
 

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