Controlled colonic insufflation by a remotely triggered capsule for improved mucosal visualization

Trisha Pasricha; Byron F. Smith; Victoria R. Mitchell; Brian Fang; Erik R. Brooks; Jason S. Gerding; Mary Kay Washington; Pietro Valdastri; Keith L. Obstein

doi:10.1055/s-0034-1365497

Endoscopy, Table of Contents

Endoscopy 2014; 46(07): 614-618
DOI: 10.1055/s-0034-1365497

Innovations and brief communications

Controlled colonic insufflation by a remotely triggered capsule for improved mucosal visualization

Authors

Trisha Pasricha

¹School of Medicine, Vanderbilt University, Nashville, Tennessee, United States
Byron F. Smith

²Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, United States
Victoria R. Mitchell

²Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, United States
Brian Fang

²Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, United States
Erik R. Brooks

³Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States
Jason S. Gerding

⁴Division of Chemical Engineering, Vanderbilt University, Nashville, Tennessee, United States
Mary Kay Washington

³Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States
Pietro Valdastri

²Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, United States

⁵Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, United States
Keith L. Obstein

⁵Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

²Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, United States

Abstract

Background and study aims: Capsule endoscopy is an attractive alternative to colorectal cancer screening by conventional colonoscopy, but is currently limited by compromised mucosal visibility because of the lack of safe, controlled colonic insufflation. We have therefore developed a novel system of untethered, wireless-controlled carbon dioxide (CO₂) insufflation for use in colonic capsule endoscopy, which this study aims to assess in vivo.

Material and methods: This observational, nonsurvival, in vivo study used five Yorkshire-Landrace cross swine. A novel insufflation capsule was placed in the porcine colons, and we recorded volume of insufflation, time, force, visualization, and a pathologic assessment of the colon.

Results: The mean (standard deviation [SD]) diameter of insufflation was 32.1 (3.9) mm. The volume of CO₂ produced successfully allowed complete endoscopic visualization of the mucosa and safe proximal passage of the endoscope. Pathologic examination demonstrated no evidence of trauma caused by the capsule.

Conclusions: These results demonstrate the feasibility of a novel method of controlled colonic insufflation via an untethered capsule in vivo. This technological innovation addresses a critical need in colon capsule endoscopy.

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References

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