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Immunologische Ursachen für sekundäre Autoimmunität unter Alemtuzumab

Alemtuzumab (Lemtrada^®) ist seit Oktober 2013 in Deutschland zur Therapie von Patienten mit aktiver Multipler Sklerose zugelassen. Dieser gegen das Oberflächenmolekül CD52 gerichtete Antikörper führt zu einer antikörper- sowie komplementvermittelten Immunzelldepletion, insbesondere von T- und B-Lymphozyten [1]. Die anschließende Repopulation folgt einem spezifischen Muster: Die Erholung von B-Zellen benötigt 3 Monate, die von CD⁸⁺-T-Zellen 20 Monate und von CD⁴⁺-T-Zellen 35 Monate [2].

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