DMW - Deutsche Medizinische Wochenschrift, Inhaltsverzeichnis Dtsch Med Wochenschr 2014; 139(28/29): 1482-1488DOI: 10.1055/s-0034-1370152 Übersicht | Review article Dermatologie, Gastroenterologie © Georg Thieme Verlag KG Stuttgart · New YorkHautmanifestationen bei gastrointestinalen ErkrankungenSkin changes as signs of gastrointestinal disorders D. Kulichová 1 Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität München , J. Schauber 1 Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität München , T. Ruzicka 1 Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität München› InstitutsangabenArtikel empfehlen Abstract Artikel einzeln kaufen Zusammenfassung Bei vielen gastrointestinalen Krankheiten sind assoziierte Hauterkrankungen und kutane Begleitsymptome oft als erstes Zeichen zu sehen und ermöglichen daher eine frühere Diagnose der inneren Erkrankung. Zu den gastrointestinalen Krankheiten mit charakteristischen Hautveränderungen zählen zahlreiche Tumoren sowie entzündliche und vaskuläre Erkrankungen. Die Kenntnis der klinischen Bilder und deren Assoziationen ist für Dermatologen und Gastroenterologen von großer Bedeutung. Abstract In many gastrointestinal disorders associated skin diseases and cutaneous signs can be seen as first manifestations and make a diagnosis of the internal disease possible. Gastrointestinal disorders with characteristic skin lesions include various tumors, inflammatory and vascular diseases. Knowledge of the clinical presentations and their associations is important both for dermatologists and gastroenterologists. Schlüsselwörter SchlüsselwörterPolyposis-Syndrom - Paraneoplasie - chronisch-entzündliche Darmerkrankungen - Malnutrition - Vaskulitis - Zöliakie - Morbus Duhring Keywords Keywordspolyposis-syndrom - paraneoplasia - chronic inflammatory bowel disease - malnutrition - vasculitis - coeliac disease - Duhring's disease Volltext Referenzen Literatur 1 Abbas O, Mahalingam M. Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm. J Cutan Pathol 2009; 36: 613-619 2 Aggarwal G, Obideen K, Wehbi M. Carcinoid tumors: what should increase our suspicion?. Cleve Clin J Med 2008; 75: 849-855 3 Alexander EK, Chan-Smutko G, Saksena MA et al. Case records of the Massachusetts General Hospital. Case 19-2013. A 35-year-old woman with recurrent goiter and ductal carcinoma of the breast. N Engl J Med 2013; 368: 2416-2424 4 Baudendistel TE, Haase AK, Fitzgerald F. The leading diagnosis. N Engl J Med 2007; 357: 2389-2393 5 Bazex A, Griffiths A. Acrokeratosis paraneoplastica – a new cutaneous marker of malignancy. Br J Dermatol 1980; 103: 301-306 6 Bogenrieder T, Stolz W. From the New World. Louis A. Duhring and Dermatitis Herpetiformis. Hautarzt 2003; 54: 167-172 7 Bohrer I, Roy M, Nager W et al. Skorbut – eine zu Unrecht vergessene Hypovitaminose. MMW 2007; 149: 41-43 8 Brinckmann J, Behrens P, Brenner R et al. Ehlers-Danlos-Syndrom. Hautarzt 1999; 50: 257-265 9 Bronner MP. Gastrointestinal polyposis syndromes. Am J Med Genet A 2003; 122A: 335-341 10 Callen JP, Jackson JM. Pyoderma gangraenosum: an update. Rheum Dis Clin North Am 2007; 33: 787-802 11 Catassi C, Rätsch IM, Fabiani E. Eine Reise durch die Welt der Zöliakie. Annales Nestlé 2004; 62: 101-115 12 Chen TS, Chen PS. Rise and fall of the Plummer-Vinson syndrome. J Gastroenterol Hepatol 1994; 9: 654-658 13 Collin P, Reunala T. Recognition and management of the cutaneous manifestations of celiac disease: a guide for dermatologists. Am J Clin Dermatol 2003; 4: 13-20 14 Cronkhite LW, Canada WJ. Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia. N Engl J Med 1955; 252: 1011-1015 15 Dajani YF, Kamal MF. Colorectal juvenile polyps: an epidemiological and histopathological study of 144 cases in Jordanians. Histopathology 1984; 8: 765e79. 16 Echenique-Elizondo ML, Tuneu Valls A, Elorza Orúe JL et al. Glucagonoma and pseudoglucagonoma syndrome. JOP 2004; 5: 179-185 17 Eng C. Will the real Cowden syndrome please stand up: revised diagnostic criteria. Med Genet 2000; 37: 828-830 18 Ferner RE. Neurofibromatosis 1 and neurofibromatosis 2: a twenty first century perspective. Lancet Neurol 2007; 6: 340-351 19 Gardner EJ. A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum. Am J Hum Genet 1951; 3: 167-176 20 Guest GD, Fink RL. Metastatic Crohn's disease: case report of an unusual variant and review of the literature. Dis Colon Rectum 2000; 43: 1764-1766 21 Hare HH, Mahendraker N, Sarwate S et al. Muir-Torre syndrome: a rare but important disorder. Cutis 2008; 82: 252-256 22 Hendricks WM. Pellagra and pellagralike dermatoses: etiology, differential diagnosis, dermatopathology and treatment. Semin Dermatol 1991; 10: 282-292 23 Heng MCY. Henoch-Schönlein Purpura. Br J Dermatol 1985; 112: 235-240 24 Henoch E. Über den Zusammenhang von Purpura und Intestinalstörungen. Berliner Klin Wochenschr 1868; 5: 517-519 25 Hobert JA, Eng C. PTEN hamartoma tumor syndrome: an overview. Genet Med 2009; 11: 687-694 26 Junnarkar SP, Sloan JM, Johnston BT et al. Cronkhite-Canada syndrome. Ulster Med J 2001; 70: 56-58 27 Karabulut AA, Sahin S, Sahin M et al. Paraneoplastic acrokeratosis of Bazex (Bazex's syndrome): report of a female case associated with cholangiocarcinoma and review of the published work. J Dermatol 2006; 33: 850-854 28 Karthikeyan K, Thappa DM. Pellagra and skin. Int J Dermatol 2002; 41: 476-481 29 Kopáčová M, Urban O, Cyrany J et al. Cronkhite-Canada Syndrome: Review of the Literature. Gastroenterol Res Pract 2013; 2013: 856873 30 Krawczyk M, Mykala-Ciesla J, Kolodziej-Jaskula A. Acanthosis nigricans as a paraneoplastic syndrome. Case reports and review of literature. Pol Arch Med Wewn 2009; 119: 180-183 31 Kruse R, Rutten A, Lamberti C et al. Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria. Am J Hum Genet 1998; 63: 63-70 32 Lobel EZ, Korelitz BI, Warman JI. Red man syndrome and infliximab. J Clin Gastroenterol 2003; 36: 186 33 Loftus Jr EV. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 2004; 126: 1504-1517 34 Deckert M, Reifenberger G, Riede U-N et al. Nervensystem. In: Riede UN, Werner M, Schäfer HE, editors. Allgemeine und Spezielle Pathologie. 5th. ed. Stuttgart: 2004: 1104 35 Modlin IM, Oberg K, Chung DC et al. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 2008; 9: 61-72 36 Moore RL, Devere TS. Epidermal manifestations of internal malignancy. Dermatol Clin 2008; 26: 17-29 37 Morais P, Ferreira O, Magina S et al. Classic Ehlers-Danlos syndrome: case report and brief review of literature. Acta Dermatovenerol Croat 2013; 21: 118-122 38 Nagata J, Kijima H, Hasumi K et al. Adenocarcinoma and multiple adenomas of the large intestine, associated with Cronkhite-Canada syndrome. Dig Liver Dis 2003; 35: 434-438 39 Ocran K, Förster U, Haake K et al. Hereditary hemorrhagic teleangiectasia (Osler-Weber-Rendu disease). Dtsch Med Wochenschr 2003; 128: 2593-2597 40 Pattamadilok B, Devpura S, Syed ZU et al. Quantitative skin color measurements in acanthosis nigricans patients: colorimetry and diffuse reflectance spectroscopy. Photodermatol Photoimmunol Photomed 2012; 28: 213-215 41 Perafan-Riveros C. Acrodermatitis enteropathica: case report and review of the literature. Pediatr Dermatol 2002; 19: 426-431 42 Pimentel L. Scurvy: historical review and current diagnostic approach. Am J Emerg Med 2003; 21: 328-332 43 Plomp AS, Toonstra J, Bergen AA et al. Proposal for updating the pseudoxanthoma elasticum classification system and review of the clinical findings. Am J Med Genet A 2010; 152A: 1049-1058 44 Potthoff A, Brockmeyer NH. HIV-associated Kaposi sarcoma: pathogenesis and therapy. J Dtsch Dermatol Ges 2007; 5: 1091-1094 45 Rammohan A, Wood JJ. Desmoid tumour of the breast as a manifestation of Gardner's syndrome. Int J Surg Case Rep 2012; 3: 139-142 46 Rashtak S, Pittelkow MR. Skin involvement in systemic autoimmune diseases. Curr Dir Autoimmun 2008; 10: 344-358 47 Rice JS, Fischer DS. Blue rubber bleb nevus syndrome. Arch Dermatol 1962; 86: 503-511 48 Rolstad BS, Erwin-Toth PL. Peristomal skin complications: prevention and management. Ostomy Wound Manage 2004; 50: 68-77 49 Ruzicka T, Schauber J. Aus zwei Blickwinkeln. Haut und Gastrointestinaltrakt – Sicht des Dermatologen. In: Ruzicka T, Wolff H, editors. Fortschritte der praktischen Dermatologie und Venerologie 2008. 1st. ed. Berlin Heidelberg: Springer Verlag; 2009: 403-411 50 Salmi TTL, Hervonen K, Kautiainen H et al. Prevalence and incidence of dermatitis herpetiformis: a 40-year prospective study from Finland. Br J Dermatol 2011; 165: 354-359 51 Sroa NL, Witman P. Howel-Evans syndrome: a variant of ectodermal dysplasia. Cutis 2010; 85: 183-185 52 Stoddart ML, Blevins KS, Lee ET et al. Association of acanthosis nigricans with hyperinsulinemia compared with other selected risk factors for type 2 diabetes in Cherokee Indians: the Cherokee Diabetes Study. Diabetes Care 2002; 25: 1009-1014 53 Stone SP, Buescher LS. Life-threatening paraneoplastic cutaneous syndromes. Clin Dermatol 2005; 23: 301-306 54 Utsunomiya J, Gocho H, Miyanaga T et al. PeutzeJeghers syndrome: its natural course and management. Johns Hopkins Med J 1975; 136: 71e82 55 Vernia P, Marcheggiano A, Marinaro V et al. Is Cronkhite-Canada syndrome necessarily a late-onset disease?. Eur J Gastroenterol Hepatol 2005; 17: 1139-1141 56 Vicktor C, Schultz-Ehrenburg U. Malignant atrophic papulosis (Köhlmeier-Degos): diagnosis, therapy and course. Hautarzt 2001; 52: 734-737 57 Vielhauer V, Herzinger T, Korting HC. The sign of Leser-Trelat: a paraneoplastic cutaneous syndrome that facilitates early diagnosis of occult cancer. Eur J Med Res 2000; 5: 512-516 58 von Felbert V, Hunziker T. Acrodermatitis-enteropathica-ähnliche Hautveränderungen bei M. Crohn-bedingtem Zinkmangel. Hautarzt 2010; 61: 927-929 59 Williams H, Walker D, Orchard TR. Extraintestinal manifestations of inflammatory bowel disease. Curr Gastroenterol Rep 2008; 10: 597-605 60 Winship IM, Dudding TE. Lessons from the skin – cutaneous features of familial cancer. Lancet Oncol 2008; 9: 462-472 61 Yukselen V, Karaoglu AO, Yasa MH. Plummer-Vinson syndrome: a report of three cases. Int J Clin Pract 2003; 57: 646-648