Ibuprofen Dependence: A Case Report

Abstract

Ibuprofen is currently widely prescribed and has not been reported to produce dependence. We report the case of a 17-year old patient who presented many positive psychics symptoms related to a pharmacological dependence. During the treatment, she adjusted herself posology as she developed withdrawal symptoms. Pharmacological evidences (effect on COX-1 and COX-2, FAAH and PPARs) allow us to formulate hypotheses explaining this effect.

Key words

ibuprofen - dependence - cannabinoid receptor modulators - peroxisome proliferator-activated

^* These two authors are first co-authors.

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