The Applications of Palladacycles as Transition-Metal Catalysts in Organic Synthesis

Abstract

This account summarizes our recent work on palladacycles in organic synthesis and describes some unique catalytic properties of palladacycles as transition-metal catalysts for some useful transformations. Asymmetric induction has been realized by using chiral palladacycles as transition-metal catalysts. The influence of the C−Pd bond of palladacycles on their catalytic activity has been revealed. The reaction selectivity can be switched by appropriate choice of an sp²- or sp³-hybridized C,P-palladacycle catalyst.

1 Introduction

2 The Discovery of the Use of Palladacycles as Transition-Metal Catalysts and Their Applications in Asymmetric Catalysis

3 Switch Between Addition and Ring Opening in the Reaction of Oxabicyclic Alkenes with Terminal Alkynes by Catalysis with sp²-C,P- or sp³-C,P-Palladacycles

4 Synthesis of Polysubstituted Furans, Methylenecyclopropanes, and Polycyclic 5H-Benzo[b]azepines through Catalysis by Palladacycles

5 Conclusions

Key words

palladacycles - transition metals - catalysis - asymmetric catalysis - bicyclic compounds - alkenes

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