Neurometabolic Aspects of Sports-Related Concussion

Delfina C. Domínguez; Mrudula Raparla

doi:10.1055/s-0034-1384677

Seminars in Speech and Language, Inhaltsverzeichnis

Semin Speech Lang 2014; 35(03): 159-165
DOI: 10.1055/s-0034-1384677

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neurometabolic Aspects of Sports-Related Concussion

Authors

Delfina C. Domínguez

¹Clinical Laboratory Sciences
Mrudula Raparla

²Interdisciplinary Health Sciences, The University of Texas at El Paso, El Paso, Texas

Abstract

Concussion is a transitory brain injury resulting from a blow to the head. Concussion is considered a mild traumatic brain injury (mTBI), which is self-limited. Repetitive mTBI has been associated with chronic, progressive neurologic damage. Extreme biochemical changes occur in neuron cells as a result of mTBI. These metabolic disturbances may reflect the symptoms observed in patients who had concussions. However, it has been difficult to match clinical signs and symptoms. Currently, there is no test to diagnose concussion. Further studies are needed to elucidate the biochemical details of the metabolic cascade and the associated time frame, which will help determine when an athlete can safely return to the game.

Keywords

Mild traumatic brain injury - concussion - chronic traumatic encephalopathy - second impact syndrome

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Referenzen

References
1 Giza CC, Hovda DA. The neurometabolic cascade of concussion. J Athl Train 2001; 36 (3) 228-235
2 Signoretti S, Lazzarino G, Tavazzi B, Vagnozzi R. The pathophysiology of concussion. PM R 2011; 3 (10) (Suppl. 02) S359-S368
3 Harmon KG, Drezner JA, Gammons M , et al. American Medical Society for Sports Medicine position statement: concussion in sport. Br J Sports Med 2013; 47 (1) 15-26
4 Zetterberg H, Smith DH, Blennow K. Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nat Rev Neurol 2013; 9 (4) 201-210
5 Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, McLean AJ. Staining of amyloid precursor protein to study axonal damage in mild head injury. Lancet 1994; 344 (8929) 1055-1056
6 Browne KD, Chen XH, Meaney DF, Smith DH. Mild traumatic brain injury and diffuse axonal injury in swine. J Neurotrauma 2011; 28 (9) 1747-1755
7 Smith DH, Nonaka M, Miller R , et al. Immediate coma following inertial brain injury dependent on axonal damage in the brainstem. J Neurosurg 2000; 93 (2) 315-322
8 Baugh CM, Stamm JM, Riley DO , et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav 2012; 6 (2) 244-254
9 Dashnaw ML, Petraglia AL, Bailes JE. An overview of the basic science of concussion and subconcussion: where we are and where we are going. Neurosurg Focus 2012; 33 (6) (Suppl. 05) E5 , 1–9
10 McCrory P, Meeuwisse WH, Aubry M , et al. Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport, Zurich, November 2012. J Athl Train 2013; 48 (4) 554-575
11 Di Battista AP, Rhind SG, Baker AJ. Application of blood-based biomarkers in human mild traumatic brain injury. Front Neurol 2013; 4: 44
12 Ommaya AK. Head injury mechanisms and the concept of preventive management: a review and critical synthesis. J Neurotrauma 1995; 12 (4) 527-546
13 Frattalone AR, Ling GS. Moderate and severe traumatic brain injury: pathophysiology and management. Neurosurg Clin N Am 2013; 24 (3) 309-319
14 Dominguez DC. Calcium signalling in bacteria. Mol Microbiol 2004; 54 (2) 291-297
15 Domiguez D, Lopes R, Holland B, Campbell A. Proteome analysis of B. subtilis in response to calcium. J Anal Bioanal Tech 2011; S6: 001
16 Vagnozzi R, Signoretti S, Cristofori L , et al. Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain 2010; 133 (11) 3232-3242
17 Maxwell WL, Graham DI. Loss of axonal microtubules and neurofilaments after stretch-injury to guinea pig optic nerve fibers. J Neurotrauma 1997; 14 (9) 603-614
18 Sternberger LA, Sternberger NH. Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci U S A 1983; 80 (19) 6126-6130
19 Nakamura Y, Takeda M, Angelides KJ, Tanaka T, Tada K, Nishimura T. Effect of phosphorylation on 68 KDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro. Biochem Biophys Res Commun 1990; 169 (2) 744-750
20 Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev 1990; 2 (2) 161-192
21 Muir JK, Boerschel M, Ellis EF. Continuous monitoring of posttraumatic cerebral blood flow using laser-Doppler flowmetry. J Neurotrauma 1992; 9 (4) 355-362
22 Len TK, Neary JP, Asmundson GJ, Goodman DG, Bjornson B, Bhambhani YN. Cerebrovascular reactivity impairment after sport-induced concussion. Med Sci Sports Exerc 2011; 43 (12) 2241-2248
23 Maugans TA, Farley C, Altaye M, Leach J, Cecil KM. Pediatric sports-related concussion produces cerebral blood flow alterations. Pediatrics 2012; 129 (1) 28-37
24 Block ML, Hong JS. Chronic microglial activation and progressive dopaminergic neurotoxicity. Biochem Soc Trans 2007; 35 (Pt 5) 1127-1132
25 Blaylock RL, Maroon J. Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy—a unifying hypothesis. Surg Neurol Int 2011; 2: 107
26 Saunders RL, Harbaugh RE. The second impact in catastrophic contact-sports head trauma. JAMA 1984; 252 (4) 538-539
27 Cantu RC, Gean AD. Second-impact syndrome and a small subdural hematoma: an uncommon catastrophic result of repetitive head injury with a characteristic imaging appearance. J Neurotrauma 2010; 27 (9) 1557-1564
28 Hovda DA. Effect of hyperglycemia after cortical injury. Crit Care Med 1997; 25 (8) 1267-1268
29 Kanayama G, Takeda M, Niigawa H , et al. The effects of repetitive mild brain injury on cytoskeletal protein and behavior. Methods Find Exp Clin Pharmacol 1996; 18 (2) 105-115
30 Conte V, Uryu K, Fujimoto S , et al. Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury. J Neurochem 2004; 90 (3) 758-764
31 Uryu K, Laurer H, McIntosh T , et al. Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. J Neurosci 2002; 22 (2) 446-454
32 McKee AC, Cantu RC, Nowinski CJ , et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009; 68 (7) 709-735
33 Martland HS. Punch drunk. Journal of the American Medical Association 1928; 91 (15) 1103-1107
34 Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 2005; 57 (1) 128-134 , discussion 128–134
35 McKee AC, Stein TD, Nowinski CJ , et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 2013; 136 (1) 43-64
36 McKee AC, Daneshvar DH, Alvarez VE, Stein TD. The neuropathology of sport. Acta Neuropathol 2014; 127 (1) 29-51