Drug Res (Stuttg) 2015; 65(09): 479-483
DOI: 10.1055/s-0034-1387756
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Antiatherosclerotic Potential of Rhizoma Polygonati Polysaccharide in Hyperlipidemia-induced Atherosclerotic Hamsters

X. Zhu
1   Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China
,
Q. Li
1   Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China
,
F. Lu
2   New York University School of Medicine, New York, USA
,
H. Wang
1   Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China
,
S. Yan
1   Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China
,
Q. Wang
1   Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China
,
W. Zhu
1   Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China
› Author Affiliations
Further Information

Publication History

received 25 September 2013

accepted 06 August 2014

Publication Date:
10 September 2014 (online)

Abstract

The present study aimed to investigate the antiatherosclerotic effect of rhizoma polygonati polysaccharide. Adult golden hamsters (Mesocricetus auratus) were fed an atherosclerotic diet containing 1.5 mL olive oil, 8 mg (320 000 IU) vitamin D2, and 40 mg cholesterol for 60 consecutive days to induce atherosclerosis. These hamsters then orally received either the reference drug simvastatin (5 mg/kg) or rhizoma polygonati polysaccharide (0.57 g/kg or 1.14 g/kg) once daily for 60 additional days before comparison to normal and atherosclerotic controls. Treatment with rhizoma polygonati polysaccharide resulted in significant improvement (p<0.01) in serum lipid profile, apolipoproteins, and endothelial dysfunction parameters. Histomorphological studies confirmed biochemical findings. The results showed that rhizoma polygonati polysaccharide has a protective effect against hyperlipidemia-induced atherosclerosis in hamsters.