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Semin Respir Crit Care Med 2014; 35(06): 636-644
DOI: 10.1055/s-0034-1395498
DOI: 10.1055/s-0034-1395498
Convex Probe Endobronchial Ultrasound
Further Information
Publication History
Publication Date:
02 December 2014 (online)
Abstract
Convex probe endobronchial ultrasound (EBUS) is a minimally invasive diagnostic technique that allows real-time sampling of mediastinal and hilar lymph nodes and central pulmonary lesions. Its utility in diagnosing both malignant and nonmalignant diseases has led to an increased uptake and use by pulmonologists over the past decade. Because of the robust evidence supporting its safety and diagnostic yield, EBUS is now the first guideline recommended test for staging in non-small cell lung cancer (NSCLC). It has also a role in providing tissue for molecular analysis, thereby guiding in the selection of agents in the new era of personalized chemotherapies in the treatment of NSCLC. The following review highlights the evidence for EBUS in diagnosing mediastinal pathology and addresses technique, training, and competency and future directions for this technology.
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References
- 1 Rivera MP, Mehta AC, Wahidi MM. Establishing the diagnosis of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013; 143 (5, Suppl): e142S-e165S
- 2 Silvestri GA, Gonzalez AV, Jantz MA , et al. Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013; 143 (5, Suppl): e211S-e250S
- 3 Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014; 64 (1) 9-29
- 4 Wang KP, Brower R, Haponik EF, Siegelman S. Flexible transbronchial needle aspiration for staging of bronchogenic carcinoma. Chest 1983; 84 (5) 571-576
- 5 Harrow EM, Abi-Saleh W, Blum J , et al. The utility of transbronchial needle aspiration in the staging of bronchogenic carcinoma. Am J Respir Crit Care Med 2000; 161 (2, Pt 1) 601-607
- 6 Haponik EF, Shure D. Underutilization of transbronchial needle aspiration: experiences of current pulmonary fellows. Chest 1997; 112 (1) 251-253
- 7 Mehta AC, Kavuru MS, Meeker DP, Gephardt GN, Nunez C. Transbronchial needle aspiration for histology specimens. Chest 1989; 96 (6) 1228-1232
- 8 Rintoul RC, Skwarski KM, Murchison JT, Hill A, Walker WS, Penman ID. Endoscopic and endobronchial ultrasound real-time fine-needle aspiration for staging of the mediastinum in lung cancer. Chest 2004; 126 (6) 2020-2022
- 9 Becker HD. EBUS: a new dimension in bronchoscopy. Of sounds and images—a paradigm of innovation. Respiration 2006; 73 (5) 583-586
- 10 Herth F, Becker HD, Ernst A. Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial. Chest 2004; 125 (1) 322-325
- 11 Herth FJ, Eberhardt R. Actual role of endobronchial ultrasound (EBUS). Eur Radiol 2007; 17 (7) 1806-1812
- 12 Krasnik M, Vilmann P, Larsen SS, Jacobsen GK. Preliminary experience with a new method of endoscopic transbronchial real time ultrasound guided biopsy for diagnosis of mediastinal and hilar lesions. Thorax 2003; 58 (12) 1083-1086
- 13 Olympus BF-1T180 Product details. Olympus; 2014. Available at: http://www.olympus.es/medical/en/medical_systems/products_services/product_details/product_details_5953.jsp . Accessed July 16, 2014
- 14 Chin Jr R, McCain TW, Lucia MA , et al. Transbronchial needle aspiration in diagnosing and staging lung cancer: how many aspirates are needed?. Am J Respir Crit Care Med 2002; 166 (3) 377-381
- 15 Diacon AH, Schuurmans MM, Theron J , et al. Transbronchial needle aspirates: how many passes per target site?. Eur Respir J 2007; 29 (1) 112-116
- 16 Lee HS, Lee GK, Lee HS , et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer: how many aspirations per target lymph node station?. Chest 2008; 134 (2) 368-374
- 17 Memoli JS, El-Bayoumi E, Pastis NJ , et al. Using endobronchial ultrasound features to predict lymph node metastasis in patients with lung cancer. Chest 2011; 140 (6) 1550-1556
- 18 Yarmus LB, Akulian J, Lechtzin N , et al; American College of Chest Physicians Quality Improvement Registry, Education, and Evaluation (AQuIRE) Participants. Comparison of 21-gauge and 22-gauge aspiration needle in endobronchial ultrasound-guided transbronchial needle aspiration: results of the American College of Chest Physicians Quality Improvement Registry, Education, and Evaluation Registry. Chest 2013; 143 (4) 1036-1043
- 19 Kinsey CM, Arenberg DA. Endobronchial ultrasound-guided transbronchial needle aspiration for non-small cell lung cancer staging. Am J Respir Crit Care Med 2014; 189 (6) 640-649
- 20 Yarmus L, Akulian J, Gilbert C , et al. Optimizing endobronchial ultrasound for molecular analysis. How many passes are needed?. Ann Am Thorac Soc 2013; 10 (6) 636-643
- 21 Davenport RD. Rapid on-site evaluation of transbronchial aspirates. Chest 1990; 98 (1) 59-61
- 22 Diacon AH, Koegelenberg CF, Schubert P , et al. Rapid on-site evaluation of transbronchial aspirates: randomised comparison of two methods. Eur Respir J 2010; 35 (6) 1216-1220
- 23 Palombini L, Fulciniti F, Vetrani A , et al. Fine-needle aspiration biopsies of breast masses. A critical analysis of 1956 cases in 8 years (1976-1984). Cancer 1988; 61 (11) 2273-2277
- 24 Hall TLLL, Layfield LJ, Philippe A, Rosenthal DL. Sources of diagnostic error in fine needle aspiration of the thyroid. Cancer 1989; 63 (4) 718-725
- 25 Austin JH, Cohen MB. Value of having a cytopathologist present during percutaneous fine-needle aspiration biopsy of lung: report of 55 cancer patients and metaanalysis of the literature. AJR Am J Roentgenol 1993; 160 (1) 175-177
- 26 Diacon AH, Schuurmans MM, Theron J , et al. Utility of rapid on-site evaluation of transbronchial needle aspirates. Respiration 2005; 72 (2) 182-188
- 27 Baram D, Garcia RB, Richman PS. Impact of rapid on-site cytologic evaluation during transbronchial needle aspiration. Chest 2005; 128 (2) 869-875
- 28 Trisolini R, Cancellieri A, Tinelli C , et al. Rapid on-site evaluation of transbronchial aspirates in the diagnosis of hilar and mediastinal adenopathy: a randomized trial. Chest 2011; 139 (2) 395-401
- 29 Griffin AC, Schwartz LE, Baloch ZW. Utility of on-site evaluation of endobronchial ultrasound-guided transbronchial needle aspiration specimens. Cytojournal 2011; 8: 20
- 30 Eapen GA, Shah AM, Lei X , et al; American College of Chest Physicians Quality Improvement Registry, Education. Complications, consequences, and practice patterns of endobronchial ultrasound-guided transbronchial needle aspiration: Results of the AQuIRE registry. Chest 2013; 143 (4) 1044-1053
- 31 Varela-Lema L, Fernández-Villar A, Ruano-Ravina A. Effectiveness and safety of endobronchial ultrasound-transbronchial needle aspiration: a systematic review. Eur Respir J 2009; 33 (5) 1156-1164
- 32 Gu P, Zhao YZ, Jiang LY, Zhang W, Xin Y, Han BH. Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis. Eur J Cancer 2009; 45 (8) 1389-1396
- 33 von Bartheld MB, van Breda A, Annema JT. Complication rate of endosonography (endobronchial and endoscopic ultrasound): a systematic review. Respiration 2014; 87 (4) 343-351
- 34 Goldstraw P, Crowley J, Chansky K , et al; International Association for the Study of Lung Cancer International Staging Committee; Participating Institutions. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2007; 2 (8) 706-714
- 35 Yasufuku K, Chiyo M, Sekine Y , et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes. Chest 2004; 126 (1) 122-128
- 36 Herth FJ, Eberhardt R, Vilmann P, Krasnik M, Ernst A. Real-time endobronchial ultrasound guided transbronchial needle aspiration for sampling mediastinal lymph nodes. Thorax 2006; 61 (9) 795-798
- 37 Vincent BD, El-Bayoumi E, Hoffman B , et al. Real-time endobronchial ultrasound-guided transbronchial lymph node aspiration. Ann Thorac Surg 2008; 85 (1) 224-230
- 38 Holty JE, Kuschner WG, Gould MK. Accuracy of transbronchial needle aspiration for mediastinal staging of non-small cell lung cancer: a meta-analysis. Thorax 2005; 60 (11) 949-955
- 39 Wallace MB, Pascual JM, Raimondo M , et al. Minimally invasive endoscopic staging of suspected lung cancer. JAMA 2008; 299 (5) 540-546
- 40 Yasufuku K, Fujisawa T. Staging and diagnosis of non-small cell lung cancer: invasive modalities. Respirology 2007; 12 (2) 173-183
- 41 Herth FJ, Krasnik M, Kahn N, Eberhardt R, Ernst A. Combined endoscopic-endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes through a single bronchoscope in 150 patients with suspected lung cancer. Chest 2010; 138 (4) 790-794
- 42 Hwangbo B, Lee GK, Lee HS , et al. Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer. Chest 2010; 138 (4) 795-802
- 43 Detterbeck F, Puchalski J, Rubinowitz A, Cheng D. Classification of the thoroughness of mediastinal staging of lung cancer. Chest 2010; 137 (2) 436-442
- 44 Tsang GM, Watson DC. The practice of cardiothoracic surgeons in the perioperative staging of non-small cell lung cancer. Thorax 1992; 47 (1) 3-5
- 45 Little AG, Rusch VW, Bonner JA , et al. Patterns of surgical care of lung cancer patients. Ann Thorac Surg 2005; 80 (6) 2051-2056 , discussion 2056
- 46 Ernst A, Anantham D, Eberhardt R, Krasnik M, Herth FJ. Diagnosis of mediastinal adenopathy-real-time endobronchial ultrasound guided needle aspiration versus mediastinoscopy. J Thorac Oncol 2008; 3 (6) 577-582
- 47 Annema JT, van Meerbeeck JP, Rintoul RC , et al. Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. JAMA 2010; 304 (20) 2245-2252
- 48 Yasufuku K, Pierre A, Darling G , et al. A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer. J Thorac Cardiovasc Surg 2011; 142 (6) 1393-1400 , e1
- 49 Chandra S, Nehra M, Agarwal D, Mohan A. Diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle biopsy in mediastinal lymphadenopathy: a systematic review and meta-analysis. Respir Care 2012; 57 (3) 384-391
- 50 Yasufuku K, Nakajima T, Motoori K , et al. Comparison of endobronchial ultrasound, positron emission tomography, and CT for lymph node staging of lung cancer. Chest 2006; 130 (3) 710-718
- 51 De Leyn P, Vansteenkiste J, Cuypers P , et al. Role of cervical mediastinoscopy in staging of non-small cell lung cancer without enlarged mediastinal lymph nodes on CT scan. Eur J Cardiothorac Surg 1997; 12 (5) 706-712
- 52 Tahara RW, Lackner RP, Graver LM. Is there a role for routine mediastinoscopy in patients with peripheral T1 lung cancers?. Am J Surg 2000; 180 (6) 488-491 , discussion 491–492
- 53 Choi YS, Shim YM, Kim J, Kim K. Mediastinoscopy in patients with clinical stage I non-small cell lung cancer. Ann Thorac Surg 2003; 75 (2) 364-366
- 54 Wallace MB, Ravenel J, Block MI , et al. Endoscopic ultrasound in lung cancer patients with a normal mediastinum on computed tomography. Ann Thorac Surg 2004; 77 (5) 1763-1768
- 55 LeBlanc JK, Devereaux BM, Imperiale TF , et al. Endoscopic ultrasound in non-small cell lung cancer and negative mediastinum on computed tomography. Am J Respir Crit Care Med 2005; 171 (2) 177-182
- 56 Herth FJ, Ernst A, Eberhardt R, Vilmann P, Dienemann H, Krasnik M. Endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes in the radiologically normal mediastinum. Eur Respir J 2006; 28 (5) 910-914
- 57 Herth FJ, Eberhardt R, Krasnik M, Ernst A. Endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes in the radiologically and positron emission tomography-normal mediastinum in patients with lung cancer. Chest 2008; 133 (4) 887-891
- 58 Molina JR, Adjei AA, Jett JR. Advances in chemotherapy of non-small cell lung cancer. Chest 2006; 130 (4) 1211-1219
- 59 Johnson DH, Fehrenbacher L, Novotny WF , et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004; 22 (11) 2184-2191
- 60 Scagliotti GV, Parikh P, von Pawel J , et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008; 26 (21) 3543-3551
- 61 Massarelli E, Varella-Garcia M, Tang X , et al. KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. Clin Cancer Res 2007; 13 (10) 2890-2896
- 62 Maemondo M, Inoue A, Kobayashi K , et al; North-East Japan Study Group. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010; 362 (25) 2380-2388
- 63 Mok TS, Wu YL, Thongprasert S , et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361 (10) 947-957
- 64 Rosell R, Carcereny E, Gervais R , et al; Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012; 13 (3) 239-246
- 65 Kwak EL, Bang YJ, Camidge DR , et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010; 363 (18) 1693-1703
- 66 Nakajima T, Yasufuku K, Suzuki M , et al. Assessment of epidermal growth factor receptor mutation by endobronchial ultrasound-guided transbronchial needle aspiration. Chest 2007; 132 (2) 597-602
- 67 Garcia-Olivé I, Monsó E, Andreo F , et al. Endobronchial ultrasound-guided transbronchial needle aspiration for identifying EGFR mutations. Eur Respir J 2010; 35 (2) 391-395
- 68 Schuurbiers OC, Looijen-Salamon MG, Ligtenberg MJ, van der Heijden HF. A brief retrospective report on the feasibility of epidermal growth factor receptor and KRAS mutation analysis in transesophageal ultrasound- and endobronchial ultrasound-guided fine needle cytological aspirates. J Thorac Oncol 2010; 5 (10) 1664-1667
- 69 Billah S, Stewart J, Staerkel G, Chen S, Gong Y, Guo M. EGFR and KRAS mutations in lung carcinoma: molecular testing by using cytology specimens. Cancer Cytopathol 2011; 119 (2) 111-117
- 70 Santis G, Angell R, Nickless G , et al. Screening for EGFR and KRAS mutations in endobronchial ultrasound derived transbronchial needle aspirates in non-small cell lung cancer using COLD-PCR. PLoS ONE 2011; 6 (9) e25191
- 71 van Eijk R, Licht J, Schrumpf M , et al. Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR. PLoS ONE 2011; 6 (3) e17791
- 72 Nakajima T, Yasufuku K, Nakagawara A, Kimura H, Yoshino I. Multigene mutation analysis of metastatic lymph nodes in non-small cell lung cancer diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration. Chest 2011; 140 (5) 1319-1324
- 73 Navani N, Brown JM, Nankivell M , et al. Suitability of endobronchial ultrasound-guided transbronchial needle aspiration specimens for subtyping and genotyping of non-small cell lung cancer: a multicenter study of 774 patients. Am J Respir Crit Care Med 2012; 185 (12) 1316-1322
- 74 Tanner NT, Watson P, Boylan A , et al. Utilizing endobronchial ultrasound with fine-needle aspiration to obtain tissue for molecular analysis: a single-center experience. J Bronchology Interv Pulmonol 2011; 18 (4) 317-321
- 75 Mohamed S, Yasufuku K, Nakajima T , et al. Analysis of cell cycle-related proteins in mediastinal lymph nodes of patients with N2-NSCLC obtained by EBUS-TBNA: relevance to chemotherapy response. Thorax 2008; 63 (7) 642-647
- 76 Nakajima T, Yasufuku K, Suzuki M , et al. Assessment of Chemosensitivity-related Aberrant Methylation of Nonsmall Cell Lung Cancer by EBUS-TBNA. J Bronchology Interv Pulmonol 2009; 16 (1) 10-14
- 77 Navani N, Lawrence DR, Kolvekar S , et al; REMEDY Trial Investigators. Endobronchial ultrasound-guided transbronchial needle aspiration prevents mediastinoscopies in the diagnosis of isolated mediastinal lymphadenopathy: a prospective trial. Am J Respir Crit Care Med 2012; 186 (3) 255-260
- 78 Garwood S, Judson MA, Silvestri G, Hoda R, Fraig M, Doelken P. Endobronchial ultrasound for the diagnosis of pulmonary sarcoidosis. Chest 2007; 132 (4) 1298-1304
- 79 Wong M, Yasufuku K, Nakajima T , et al. Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis. Eur Respir J 2007; 29 (6) 1182-1186
- 80 Oki M, Saka H, Kitagawa C , et al. Prospective study of endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes versus transbronchial lung biopsy of lung tissue for diagnosis of sarcoidosis. J Thorac Cardiovasc Surg 2012; 143 (6) 1324-1329
- 81 Oki M, Saka H, Kitagawa C , et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration is useful for diagnosing sarcoidosis. Respirology 2007; 12 (6) 863-868
- 82 Nakajima T, Yasufuku K, Kurosu K , et al. The role of EBUS-TBNA for the diagnosis of sarcoidosis—comparisons with other bronchoscopic diagnostic modalities. Respir Med 2009; 103 (12) 1796-1800
- 83 Navani N, Booth HL, Kocjan G , et al. Combination of endobronchial ultrasound-guided transbronchial needle aspiration with standard bronchoscopic techniques for the diagnosis of stage I and stage II pulmonary sarcoidosis. Respirology 2011; 16 (3) 467-472
- 84 von Bartheld MB, Dekkers OM, Szlubowski A , et al. Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial. JAMA 2013; 309 (23) 2457-2464
- 85 Tremblay A, Stather DR, Maceachern P, Khalil M, Field SK. A randomized controlled trial of standard vs endobronchial ultrasonography-guided transbronchial needle aspiration in patients with suspected sarcoidosis. Chest 2009; 136 (2) 340-346
- 86 Gupta D, Dadhwal DS, Agarwal R, Gupta N, Bal A, Aggarwal AN. Endobronchial ultrasound-guided transbronchial needle aspiration vs conventional transbronchial needle aspiration in the diagnosis of sarcoidosis. Chest 2014; 146 (3) 547-556
- 87 Tournoy KG, Bolly A, Aerts JG , et al. The value of endoscopic ultrasound after bronchoscopy to diagnose thoracic sarcoidosis. Eur Respir J 2010; 35 (6) 1329-1335
- 88 Eckardt J, Olsen KE, Jørgensen OD, Licht PB. Minimally invasive diagnosis of sarcoidosis by EBUS when conventional diagnostics fail. Sarcoidosis Vasc Diffuse Lung Dis 2010; 27 (1) 43-48
- 89 Agarwal R, Srinivasan A, Aggarwal AN, Gupta D. Efficacy and safety of convex probe EBUS-TBNA in sarcoidosis: a systematic review and meta-analysis. Respir Med 2012; 106 (6) 883-892
- 90 Plit ML, Havryk AP, Hodgson A , et al. Rapid cytological analysis of endobronchial ultrasound-guided aspirates in sarcoidosis. Eur Respir J 2013; 42 (5) 1302-1308
- 91 Moonim MT, Breen R, Fields PA, Santis G. Diagnosis and subtyping of de novo and relapsed mediastinal lymphomas by endobronchial ultrasound needle aspiration. Am J Respir Crit Care Med 2013; 188 (10) 1216-1223
- 92 Kennedy MP, Jimenez CA, Bruzzi JF , et al. Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lymphoma. Thorax 2008; 63 (4) 360-365
- 93 Steinfort DP, Conron M, Tsui A , et al. Endobronchial ultrasound-guided transbronchial needle aspiration for the evaluation of suspected lymphoma. J Thorac Oncol 2010; 5 (6) 804-809
- 94 Marshall CB, Jacob B, Patel S , et al. The utility of endobronchial ultrasound-guided transbronchial needle aspiration biopsy in the diagnosis of mediastinal lymphoproliferative disorders. Cancer Cytopathol 2011; 119 (2) 118-126
- 95 Iqbal S, DePew ZS, Kurtin PJ , et al. Endobronchial ultrasound and lymphoproliferative disorders: a retrospective study. Ann Thorac Surg 2012; 94 (6) 1830-1834
- 96 Peto HM, Pratt RH, Harrington TA, LoBue PA, Armstrong LR. Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006. Clin Infect Dis 2009; 49 (9) 1350-1357
- 97 Codecasa LR, Besozzi G, De Cristofaro L, Miradoli A, Sabolla L, Tagliaferri B. Epidemiological and clinical patterns of intrathoracic lymph node tuberculosis in 60 human immunodeficiency virus-negative adult patients. Monaldi Arch Chest Dis 1998; 53 (3) 277-280
- 98 Navani N, Molyneaux PL, Breen RA , et al. Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study. Thorax 2011; 66 (10) 889-893
- 99 Ren S, Zhang Z, Jiang H , et al. Combination of endobronchial ultrasound-guided transbronchial needle aspiration with standard bronchoscopic techniques enhanced the diagnosis yields of pulmonary tuberculosis patients with lymphadenopathy. Panminerva Med 2013; 55 (4) 363-370
- 100 Sun J, Teng J, Yang H , et al. Endobronchial ultrasound-guided transbronchial needle aspiration in diagnosing intrathoracic tuberculosis. Ann Thorac Surg 2013; 96 (6) 2021-2027
- 101 Tanner NT, Pastis NJ, Silvestri GA. Training for linear endobronchial ultrasound among US pulmonary/critical care fellowships: a survey of fellowship directors. Chest 2013; 143 (2) 423-428
- 102 Davoudi M, Colt HG, Osann KE, Lamb CR, Mullon JJ. Endobronchial ultrasound skills and tasks assessment tool: assessing the validity evidence for a test of endobronchial ultrasound-guided transbronchial needle aspiration operator skill. Am J Respir Crit Care Med 2012; 186 (8) 773-779
- 103 Bolliger CT, Mathur PN, Beamis JF , et al; European Respiratory Society/American Thoracic Society. ERS/ATS statement on interventional pulmonology. Eur Respir J 2002; 19 (2) 356-373
- 104 Ernst A, Silvestri GA, Johnstone D ; American College of Chest Physicians. Interventional pulmonary procedures: Guidelines from the American College of Chest Physicians. Chest 2003; 123 (5) 1693-1717
- 105 Hu Y, Puri V, Crabtree TD , et al. Attaining proficiency with endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Cardiovasc Surg 2013; 146 (6) 1387-1392 , e1
- 106 Wahidi MM, Hulett C, Pastis N , et al. Learning experience of linear endobronchial ultrasound among pulmonary trainees. Chest 2014; 145 (3) 574-578
- 107 Fernández-Villar A, Leiro-Fernández V, Botana-Rial M, Represas-Represas C, Núñez-Delgado M. The endobronchial ultrasound-guided transbronchial needle biopsy learning curve for mediastinal and hilar lymph node diagnosis. Chest 2012; 141 (1) 278-279
- 108 Groth SS, Whitson BA, D'Cunha J, Maddaus MA, Alsharif M, Andrade RS. Endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes: a single institution's early learning curve. Ann Thorac Surg 2008; 86 (4) 1104-1109 , discussion 1109–1110
- 109 Steinfort DP, Hew MJ, Irving LB. Bronchoscopic evaluation of the mediastinum using endobronchial ultrasound: a description of the first 216 cases carried out at an Australian tertiary hospital. Intern Med J 2011; 41 (12) 815-824
- 110 Medford AR. Learning curve for endobronchial ultrasound-guided transbronchial needle aspiration. Chest 2012; 141 (6) 1643-, author reply 1643–1644
- 111 Kemp SV, El Batrawy SH, Harrison RN , et al. Learning curves for endobronchial ultrasound using cusum analysis. Thorax 2010; 65 (6) 534-538
- 112 Unroe MA, Shofer SL, Wahidi MM. Training for endobronchial ultrasound: methods for proper training in new bronchoscopic techniques. Curr Opin Pulm Med 2010; 16 (4) 295-300
- 113 Wahidi MM, Silvestri GA, Coakley RD , et al. A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows. Chest 2010; 137 (5) 1040-1049
- 114 Stather DR, Maceachern P, Rimmer K, Hergott CA, Tremblay A. Validation of an endobronchial ultrasound simulator: differentiating operator skill level. Respiration 2011; 81 (4) 325-332
- 115 Stather DR, MacEachern P, Chee A, Dumoulin E, Tremblay A. Evaluation of clinical endobronchial ultrasound skills following clinical versus simulation training. Respirology 2012; 17 (2) 291-299
- 116 Stather DR, Maceachern P, Rimmer K, Hergott CA, Tremblay A. Assessment and learning curve evaluation of endobronchial ultrasound skills following simulation and clinical training. Respirology 2011; 16 (4) 698-704
- 117 Sabur NF, Stather D, MacEachern P, Chee A, Tremblay A. Endobronchial ultrasound knowledge, implementation, and perceived barriers after attendance at a dedicated hands-on course. J Bronchology Interv Pulmonol 2011; 18 (2) 138-143
- 118 Steinfort DP, Liew D, Conron M, Hutchinson AF, Irving LB. Cost-benefit of minimally invasive staging of non-small cell lung cancer: a decision tree sensitivity analysis. J Thorac Oncol 2010; 5 (10) 1564-1570
- 119 Grove DA, Bechara RI, Josephs JS, Berkowitz DM. Comparative cost analysis of endobronchial ultrasound-guided and blind TBNA in the evaluation of hilar and mediastinal lymphadenopathy. J Bronchology Interv Pulmonol 2012; 19 (3) 182-187
- 120 Pastis NJ, Simkovich S, Silvestri GA. Understanding the economic impact of introducing a new procedure: calculating downstream revenue of endobronchial ultrasound with transbronchial needle aspiration as a model. Chest 2012; 141 (2) 506-512