Laryngorhinootologie 2015; 94(S 01): S1-S23
DOI: 10.1055/s-0034-1396869
Referat
© Georg Thieme Verlag KG Stuttgart · New York

Epidemiologie der chronischen Rhinosinusitis, ausgewählter Risikofaktoren und Komorbiditäten, und ihre ökonomischen Folgen

Epidemiology of Chronic Rhinosinusitis, Selected Risk Factors, Comorbidities and Economic Burden
A. G. Beule
1   Klinik für Hals-Nasen-Ohrenkrankheiten, Kopf- und Halschirurgie der Universitätsmedizin Greifswald
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Further Information

Publication History

Publication Date:
10 April 2015 (online)

Zusammenfassung

Die chronische Rhinosinusitis (CRS) ist eine epidemiologisch gesehen relevante Erkrankung in Deutschland, Europa und weltweit. Dabei weist die Prävalenz der CRS deutlich regionale und zum teil auch temporäre Schwankungen auf. Vor diesem Hintergrund werden die in der Literatur verfügbaren Angaben zur Häufigkeit der CRS nach Herkunftsland bzw. –region, Erhebungszeitpunkt sowie der Definition der Erkrankung vorgestellt. Übersichtsartig werden dabei bekannte Risikofaktoren wie Rauchen und gastro-ösophagealer Reflux in ihrem Einfluss auf die Prävalenz der CRS eingeschätzt. Ferner werden Ko-Morbiditäten mit Assoziation zur CRS, wie dem Asthma bronchiale, Herz-Kreislauf-Erkrankungen und einer Depression aufgeführt, und ihre Bedeutung für die Ausbildung einer CRS dargestellt. Neben Angaben zur Häufigkeit der CRS in besonderen Patientengruppen, wie z.B. immunsupprimierten Patienten, runden aktuelle Angaben zur ökonomischen Bedeutung der CRS auch aus Deutschland diese Übersichtsarbeit ab.

Abstract

Chronic rhinosinusitis (CRS) is a relevant and prevalent medical condition in Germany, Europe and the world. If analysed in detail, the prevalence of CRS shows regional and temporary variety. In this review, currently available data regarding the prevalence of CRS is therefore sorted by country and/or region, time point of data collection and the CRS-definition employed. Risk factors like smoking and gastro-oesophageal reflux are discussed regarding their influence on CRS prevalence. Moreover, co-morbidities of CRS, like asthma, conditions of the cardiovascular system and depression are listed and their influence on CRS is discussed. Furthermore, data on CRS prevalence in special cohorts, like immunocompromised patients, are presented. To estimate the economic burden of CRS, current data e.g. from Germany and the USA are included in this review.

 
  • Literatur

  • 1 Fokkens WJ, Lund VJ, Mullol J et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012; 50: 1-12
  • 2 Collins JG. Prevalence of selected chronic conditions: United States, 1990–1992. Vital Health Stat 1997; 10: 1-89
  • 3 Pilan RR, Pinna FR, Bezerra TF et al. Prevalence of chronic rhinosinusitis in Sao Paulo. Rhinology 2012; 50: 129-138
  • 4 Bhattacharyya N, Grebner J, Martinson NG. Recurrent acute rhinosinusitis: epidemiology and health care cost burden. Otolaryngol Head Neck Surg 2012; 146: 307-312
  • 5 Hughes RG, Jones NS. The role of nasal endoscopy in outpatient management. Clinical otolaryngology and allied sciences 1998; 23: 224-226
  • 6 Bhattacharyya N. Clinical and symptom criteria for the accurate diagnosis of chronic rhinosinusitis. The Laryngoscope 2006; 116: 1-22
  • 7 Tomassen P, Newson RB, Hoffmans R et al. Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis – a GA(2) LEN study. Allergy 2011; 66: 556-561
  • 8 Blackwell DL, Collins JG, Coles R. Summary health statistics for US adults: National Health Interview Survey, 1997. Vital Health Stat 2002; 10: 1-109
  • 9 Min YG, Jung HW, Kim HS, Park SK, Yoo KY. Prevalence and risk factors of chronic sinusitis in Korea: results of a nationwide survey. Eur Arch Otorhinolaryngol 1996; 253: 435-439
  • 10 Cho YS, Choi SH, Park KH et al. Prevalence of otolaryngologic diseases in South Korea: data from the Korea national health and nutrition examination survey 2008. Clin Exp Otorhinolaryngol 2010; 3: 183-193
  • 11 Hastan D, Fokkens WJ, Bachert C et al. Chronic rhinosinusitis in Europe – an underestimated disease. A GA(2)LEN study. Allergy 2011; 66: 1216-1223
  • 12 Fokkens W, Lund V, Mullol J. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology 2007; 45: 97-101
  • 13 Stuck BA, Bachert C, Federspil P et al. Leitlinie „Rhinosinusitis“-Langfassung: S2-Leitlinie der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Hno 2012; 60: 141-162
  • 14 Johansson L, Akerlund A, Holmberg K, Melen I, Bende M. Prevalence of nasal polyps in adults: the Skovde population-based study. Ann Otol Rhinol Laryngol 2003; 112: 625-629
  • 15 Settipane GA, Chafee FH. Nasal polyps in asthma and rhinitis. A review of 6,037 patients. J Allergy Clin Immunol 1977; 59: 17-21
  • 16 Drake-Lee AB, Lowe D, Swanston A, Grace A. Clinical profile and recurrence of nasal polyps. J Laryngol Otol 1984; 98: 783-793
  • 17 Moloney JR. Nasal polyps, nasal polypectomy, asthma, and aspirin sensitivity. Their association in 445 cases of nasal polyps. J Laryngol Otol 1977; 91: 837-846
  • 18 Larsen K, Tos M. Clinical course of patients with primary nasal polyps. Acta Otolaryngol 1994; 114: 556-559
  • 19 Larsen PL, Tos M. Origin of nasal polyps: an endoscopic autopsy study. The Laryngoscope 2004; 114: 710-719
  • 20 Larsen PL, Tos M. Site of origin of nasal polyps. Transcranially removed naso-ethmoidal blocks as a screening method for nasal polyps in autopsy material. Rhinology 1995; 33: 185-188
  • 21 Larsen P, Tos M. Anatomic site of origin of nasal polyps: Endoscopic Nasal and Paranasal Sinus Surgery as a Screening Method for Nasal Polyps in an Autopsy Material. Am j Rhinol 1996; 10: 211-216
  • 22 Drake-Lee AB. Nasal polyps. In: Mygind N, Naclerio R. Hrsg Allergic and nonallergic rhinitis. Copenhagen: Munksgaard; 1993
  • 23 Larsen K, Tos M. The estimated incidence of symptomatic nasal polyps. Acta Otolaryngol 2002; 122: 179-182
  • 24 Abdalla S, Alreefy H, Hopkins C. Prevalence of sinonasal outcome test (SNOT-22) symptoms in patients undergoing surgery for chronic rhinosinusitis in the England and Wales National prospective audit. Clin Otolaryngol 2012; 37: 276-282
  • 25 Johansson L, Bramerson A, Holmberg K et al. Clinical relevance of nasal polyps in individuals recruited from a general population-based study. Acta Otolaryngol 2004; 124: 77-81
  • 26 Klossek JM, Neukirch F, Pribil C et al. Prevalence of nasal polyposis in France: a cross-sectional, case-control study. Allergy 2005; 60: 233-237
  • 27 Hedman J, Kaprio J, Poussa T, Nieminen MM. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 1999; 28: 717-722
  • 28 deShazo RD. Fungal sinusitis. The American journal of the medical sciences 1998; 316: 39-45
  • 29 deShazo RD, O’Brien M, Chapin K et al. Criteria for the diagnosis of sinus mycetoma. The Journal of allergy and clinical immunology 1997; 99: 475-485
  • 30 Zhang GH, Li Y, Zeng ZP et al. Study on correlated factors and clinical features of fungal rhinosinusitis. Chinese journal of otorhinolaryngology head and neck surgery 2006; 41: 163-166
  • 31 Bent 3rd JP, Kuhn FA. Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg 1994; 111: 580-588
  • 32 Montone KT, Livolsi VA, Feldman MD et al. Fungal rhinosinusitis: a retrospective microbiologic and pathologic review of 400 patients at a single university medical center. Int J Otolaryngol 2012; 2012: 684835.
  • 33 Ferguson BJ, Barnes L, Bernstein JM et al. Geographic variation in allergic fungal rhinosinusitis. Otolaryngologic clinics of North America 2000; 33: 441-449
  • 34 Miller JD, Deal AM, McKinney KA et al. Markers of disease severity and socioeconomic factors in allergic fungal rhinosinusitis. International forum of allergy & rhinology 2014; 4: 272-279
  • 35 Zakirullah Nawaz G, Sattar SF. Presentation and diagnosis of allergic fungal sinusitis. J Ayub Med Coll Abbottabad 2010; 22: 53-57
  • 36 Bassiouny A, Ragab A, Attia AF et al. Prevalence of extramucosal fungal elements in sinonasal polyposis: a mycological and pathologic study in an Egyptian population. Am J Otolaryngol 2011; 32: 308-317
  • 37 Clark DW, Wenaas A, Luong A, Citardi MJ, Fakhri S. Staphylococcus aureus prevalence in allergic fungal rhinosinusitis vs. other subsets of chronic rhinosinusitis with nasal polyps. International forum of allergy & rhinology 2013; 3: 89-93
  • 38 Turner JH, Soudry E, Nayak JV, Hwang PH. Survival outcomes in acute invasive fungal sinusitis: a systematic review and quantitative synthesis of published evidence. The Laryngoscope 2013; 123: 1112-1118
  • 39 Prateek S, Banerjee G, Gupta P et al. Fungal rhinosinusitis: a prospective study in a University hospital of Uttar Pradesh. Indian J Med Microbiol 2013; 31: 266-269
  • 40 Das A, Bal A, Chakrabarti A, Panda N, Joshi K. Spectrum of fungal rhinosinusitis; histopathologist’s perspective. Histopathology 2009; 54: 854-859
  • 41 Panda NK, Sharma SC, Chakrabarti A, Mann SB. Paranasal sinus mycoses in north India. Mycoses 1998; 41: 281-286
  • 42 Driemel O, Wagner C, Hurrass S et al. Allergische Pilzsinusitis, Fungusball und invasive Mykose der Nasennebenhöhlen – drei distinkte, pilzinduzierte Krankheitsbilder. Mund Kiefer Gesichtschir 2007; 11: 153-159
  • 43 Lee AS, Przybyszewski B, Montone K, Lanza DC. Oral antifungal therapy for Fusarium-associated chronic rhinosinusitis. International forum of allergy & rhinology 2012; 2: 45-50
  • 44 Michael RC, Michael JS, Ashbee RH, Mathews MS. Mycological profile of fungal sinusitis: An audit of specimens over a 7-year period in a tertiary care hospital in Tamil Nadu. Indian J Pathol Microbiol 2008; 51: 493-496
  • 45 Ganguly R, Ramesh A. Odontogenic sinusitis: an underdiagnosed condition. J Mass Dent Soc 2014; 63: 46-47
  • 46 Longhini AB, Branstetter BF, Ferguson BJ. Otolaryngologists’ perceptions of odontogenic maxillary sinusitis. The Laryngoscope 2012; 122: 1910-1914
  • 47 Hoskison E, Daniel M, Rowson JE, Jones NS. Evidence of an increase in the incidence of odontogenic sinusitis over the last decade in the UK. J Laryngol Otol 2012; 126: 43-46
  • 48 Psaltis AJ, Ha KR, Beule AG, Tan LW, Wormald PJ. Confocal scanning laser microscopy evidence of biofilms in patients with chronic rhinosinusitis. The Laryngoscope 2007; 117: 1302-1306
  • 49 Ferguson BJ, Stolz DB. Demonstration of biofilm in human bacterial chronic rhinosinusitis. American journal of rhinology 2005; 19: 452-457
  • 50 Bendouah Z, Barbeau J, Hamad WA, Desrosiers M. Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with an unfavorable evolution after surgery for chronic sinusitis and nasal polyposis. Otolaryngol Head Neck Surg 2006; 134: 991-996
  • 51 Zhang Z, Linkin DR, Finkelman BS et al. Asthma and biofilm-forming bacteria are independently associated with revision sinus surgeries for chronic rhinosinusitis. The Journal of allergy and clinical immunology 2011; 128: 221-223 e221
  • 52 You H, Zhuge P, Li D et al. Factors affecting bacterial biofilm expression in chronic rhinosinusitis and the influences on prognosis. Am J Otolaryngol 2011; 32: 583-590
  • 53 Zhang Z, Kofonow JM, Finkelman BS et al. Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis. Otolaryngol Head Neck Surg 2011; 144: 457-462
  • 54 Prince AA, Steiger JD, Khalid AN et al. Prevalence of biofilm-forming bacteria in chronic rhinosinusitis. American journal of rhinology 2008; 22: 239-245
  • 55 Foreman A, Holtappels G, Psaltis AJ et al. Adaptive immune responses in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Allergy 2011; 66: 1449-1456
  • 56 Sachse F, Becker K, Rudack C. Incidence of staphylococcal colonization and of the 753Q Toll-like receptor 2 variant in nasal polyposis. American journal of rhinology & allergy 2010; 24: e10-e13
  • 57 Psaltis AJ, Wormald PJ, Ha KR, Tan LW. Reduced levels of lactoferrin in biofilm-associated chronic rhinosinusitis. The Laryngoscope 2008; 118: 895-901
  • 58 Rujanavej V, Soudry E, Banaei N et al. Trends in incidence and susceptibility among methicillin-resistant Staphylococcus aureus isolated from intranasal cultures associated with rhinosinusitis. American journal of rhinology & allergy 2013; 27: 134-137
  • 59 Gorwitz RJ. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and update. Pediatr Infect Dis J 2008; 27: 925-926
  • 60 Manarey CR, Anand VK, Huang C. Incidence of methicillin-resistant Staphylococcus aureus causing chronic rhinosinusitis. The Laryngoscope 2004; 114: 939-941
  • 61 Jiang RS, Jang JW, Hsu CY. Post-functional endoscopic sinus surgery methicillin-resistant Staphylococcus aureus sinusitis. American journal of rhinology 1999; 13: 273-277
  • 62 Bhattacharyya N, Kepnes LJ. Assessment of trends in antimicrobial resistance in chronic rhinosinusitis. The Annals of otology, rhinology, and laryngology 2008; 117: 448-452
  • 63 McCoul ED, Jourdy DN, Schaberg MR, Anand VK. Methicillin-resistant Staphylococcus aureus sinusitis in nonhospitalized patients: a systematic review of prevalence and treatment outcomes. The Laryngoscope 2012; 122: 2125-2131
  • 64 Becker SS, Russell PT, Duncavage JA, Creech CB. Current issues in the management of sinonasal methicillin-resistant Staphylococcus aureus. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 2-5
  • 65 Settipane GA. Epidemiology of nasal polyps. Allergy and asthma proceedings: the official journal of regional and state allergy societies 1996; 17: 231-236
  • 66 Maresh M, Washburg A. Paranasal sinuses from borth to Adolescence: II. Clinical and roentgenographic evidence of infection. Am J Dis Child 1940; 60: 841-861
  • 67 Gordts F, Clement PA, Buisseret T. Prevalence of sinusitis signs in a non-ENT population. ORL J Otorhinolaryngol Relat Spec 1996; 58: 315-319
  • 68 Gordts F, Clement PA, Buisseret T. Prevalence of paranasal sinus abnormalities on MRI in a non-ENT population. Acta Otorhinolaryngol Belg 1996; 50: 167-170
  • 69 Gordts F, Clement PA, Destryker A, Desprechins B, Kaufman L. Prevalence of sinusitis signs on MRI in a non-ENT paediatric population. Rhinology 1997; 35: 154-157
  • 70 Gordts F, Clement PA. Epidemiology and prevalence of aspecific chronic sinusitis. Acta Otorhinolaryngol Belg 1997; 51: 205-208
  • 71 Diament MJ, Senac Jr MO, Gilsanz V et al. Prevalence of incidental paranasal sinuses opacification in pediatric patients: a CT study. J Comput Assist Tomogr 1987; 11: 426-431
  • 72 Delagrand A, Gilbert-Dussardier B, Burg S et al. Nasal polyposis: is there an inheritance pattern? A single family study. Rhinology 2008; 46: 125-130
  • 73 Purkey MT, Li J, Mentch F et al. Genetic variation in genes encoding airway epithelial potassium channels is associated with chronic rhinosinusitis in a pediatric population. PLoS One 2014; 9: e89329
  • 74 Mulligan JK, White DR, Wang EW et al. Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps. Otolaryngol Head Neck Surg 2012; 147: 773-781
  • 75 Sedaghat AR, Phipatanakul W, Cunningham MJ. Atopy and the development of chronic rhinosinusitis in children with allergic rhinitis. J Allergy Clin Immunol Pract 2013; 1: 681-691 e689-e682
  • 76 Smith DF, Ishman SL, Tunkel DE, Boss EF. Chronic rhinosinusitis in children: race and socioeconomic status. Otolaryngol Head Neck Surg 2013; 149: 639-644
  • 77 Chapelin C, Coste A, Reinert P et al. Incidence of primary ciliary dyskinesia in children with recurrent respiratory diseases. The Annals of otology, rhinology, and laryngology 1997; 106: 854-858
  • 78 O’Callaghan C, Chetcuti P, Moya E. High prevalence of primary ciliary dyskinesia in a British Asian population. Arch Dis Child 2010; 95: 51-52
  • 79 Dodge JA, Morison S, Lewis PA et al. Incidence, population, and survival of cystic fibrosis in the UK, 1968–95. UK Cystic Fibrosis Survey Management Committee. Arch Dis Child 1997; 77: 493-496
  • 80 Association AL. Cystic Firbosis. State of Lung Disease in Diverse Communities 2010;
  • 81 Cimmino M, Cavaliere M, Nardone M et al. Clinical characteristics and genotype analysis of patients with cystic fibrosis and nasal polyposis. Clinical otolaryngology and allied sciences 2003; 28: 125-132
  • 82 Kingdom TT, Lee KC, FitzSimmons SC, Cropp GJ. Clinical characteristics and genotype analysis of patients with cystic fibrosis and nasal polyposis requiring surgery. Archives of otolaryngology – head & neck surgery 1996; 122: 1209-1213
  • 83 Hadfield PJ, Rowe-Jones JM, Mackay IS. The prevalence of nasal polyps in adults with cystic fibrosis. Clinical otolaryngology and allied sciences 2000; 25: 19-22
  • 84 Feuillet-Fieux MN, Lenoir G, Sermet I et al. Nasal polyposis and cystic fibrosis(CF): review of the literature. Rhinology 2011; 49: 347-355
  • 85 Marshak T, Rivlin Y, Bentur L, Ronen O, Uri N. Prevalence of rhinosinusitis among atypical cystic fibrosis patients. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2011; 268: 519-524
  • 86 Vital D, Holzmann D, Boehler A, Hofer M. Nasal polyposis in lung transplant recipients with cystic fibrosis. J Cyst Fibros 2013; 12: 266-270
  • 87 Wang X, Moylan B, Leopold DA et al. Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population. Jama 2000; 284: 1814-1819
  • 88 Sitarek P, Zielinska-Blizniewska H, Milonski J et al. Role of the -765 G/C polymorphism of COX-2 gene in pathogenesis of chronic rhinosinusitis with nose polyps in a Polish population. Otolaryngol Pol 2012; 66: 181-184
  • 89 Greisner 3rd WA, Settipane GA. Hereditary factor for nasal polyps. Allergy Asthma Proc 1996; 17: 283-286
  • 90 Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D. HLA patterns in patients with nasal polyposis. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2000; 257: 137-139
  • 91 Cormier C, Bosse Y, Mfuna L, Hudson TJ, Desrosiers M. Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis. Journal of otolaryngology – head & neck surgery=Le Journal d’oto-rhino-laryngologie et de chirurgie cervico-faciale 2009; 38: 133-141
  • 92 Endam LM, Bosse Y, Filali-Mouhim A et al. Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis. Otolaryngol Head Neck Surg 2009; 140: 741-747
  • 93 Zhang Y, Endam LM, Filali-Mouhim A et al. Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study. PLoS One 2012; 7: e39247
  • 94 Bush CM, Jang DW, Champagne JP, Kountakis SE. Epidemiologic factors and surgical outcomes in patients with nasal polyposis and asthma. ORL; journal for oto-rhino-laryngology and its related specialties 2013; 75: 320-324
  • 95 Pleis JR, Ward BW, Lucas JW. Summary health statistics for US adults: National Health Interview Survey, 2009. Vital Health Stat 2010; 10: 1-207
  • 96 Fan Y, Feng S, Xia W et al. Aspirin-exacerbated respiratory disease in China: a cohort investigation and literature review. American journal of rhinology & allergy 2012; 26: e20-e22
  • 97 Kasper L, Sladek K, Duplaga M et al. Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland. Allergy 2003; 58: 1064-1066
  • 98 Kim YS, Kim NH, Seong SY et al. Prevalence and risk factors of chronic rhinosinusitis in Korea. American journal of rhinology & allergy 2011; 25: 117-121
  • 99 Lee TJ, Liang CW, Chang PH, Huang CC. Risk factors for protracted sinusitis in pediatrics after endoscopic sinus surgery. Auris Nasus Larynx 2009; 36: 655-660
  • 100 Thode N, Bergmann E, Kamtsiuris P, Kurth B. Einflussfaktoren auf die Inanspruchnahme des deutschen Gesundheitswesens und mögliche Steuerungsmechanismen. Robert-Koch-Institut 2004;
  • 101 Cho SH, Hong SJ, Han B et al. Age-related differences in the pathogenesis of chronic rhinosinusitis. The Journal of allergy and clinical immunology 2012; 129: 858-860 e852
  • 102 Chen Y, Dales R, Lin M. The epidemiology of chronic rhinosinusitis in Canadians. The Laryngoscope 2003; 113: 1199-1205
  • 103 RKI . Prävalenz von Asthma bronchiale. Gesundheitsberichterstattung in Deutschland aktuell 2009;
  • 104 Obaseki D, Potts J, Joos G et al. The relation of airway obstruction to asthma, chronic rhinosinusitis and age: results from a population survey of adults. Allergy 2014; 69: 1205-1214
  • 105 Jarvis D, Newson R, Lotvall J et al. Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe. Allergy 2012; 67: 91-98
  • 106 Ek A, Middelveld RJ, Bertilsson H et al. Chronic rhinosinusitis in asthma is a negative predictor of quality of life: results from the Swedish GA(2)LEN survey. Allergy 2013; 68: 1314-1321
  • 107 Olsson P, Ehnhage A, Nordin S, Stjarne P. Quality of life is improved by endoscopic surgery and fluticasone in nasal polyposis with asthma. Rhinology 2010; 48: 325-330
  • 108 Dixon AE, Kaminsky DA, Holbrook JT et al. Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function. Chest 2006; 130: 429-435
  • 109 Alobid I, Cardelus S, Benitez P et al. Persistent asthma has an accumulative impact on the loss of smell in patients with nasal polyposis. Rhinology 2011; 49: 519-524
  • 110 Haselkorn T, Zeiger RS, Chipps BE et al. Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma. The Journal of allergy and clinical immunology 2009; 124: 921-927
  • 111 Dougherty RH, Fahy JV. Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clin Exp Allergy 2009; 39: 193-202
  • 112 Koga T, Oshita Y, Kamimura T, Koga H, Aizawa H. Characterisation of patients with frequent exacerbation of asthma. Respir Med 2006; 100: 273-278
  • 113 ten Brinke A, Sterk PJ, Masclee AA et al. Risk factors of frequent exacerbations in difficult-to-treat asthma. Eur Respir J 2005; 26: 812-818
  • 114 Rugina M, Serrano E, Klossek JM et al. Epidemiological and clinical aspects of nasal polyposis in France; the ORLI group experience. Rhinology 2002; 40: 75-79
  • 115 Crampette L, Serrano E, Klossek JM et al. Etude epidemiologique prospective multicentrique francaise (Groupe ORLI) de la pathologie pneumoallergologique associee a la polypose naso-sinusienne. Rev Laryngol Otol Rhinol (Bord) 2001; 122: 231-236
  • 116 Batra PS, Tong L, Citardi MJ. Analysis of comorbidities and objective parameters in refractory chronic rhinosinusitis. The Laryngoscope 2013; 123 (Suppl. 07) S1-S11
  • 117 Larsen K. The clinical relationship of nasal polyps to asthma. Allergy and asthma proceedings: the official journal of regional and state allergy societies 1996; 17: 243-249
  • 118 Hakansson K, Thomsen SF, Konge L et al. A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps. American journal of rhinology & allergy 2014; 28: 383-387
  • 119 Collins MM, Pang YT, Loughran S, Wilson JA. Environmental risk factors and gender in nasal polyposis. Clinical otolaryngology and allied sciences 2002; 27: 314-317
  • 120 Kelemence A, Abadoglu O, Gumus C et al. The frequency of chronic rhinosinusitis/nasal polyp in COPD and its effect on the severity of COPD. Copd 2011; 8: 8-12
  • 121 Piotrowska VM, Piotrowski WJ, Kurmanowska Z et al. Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids. Int J Chron Obstruct Pulmon Dis 2010; 5: 107-117
  • 122 Miller MK, Lee JH, Miller DP, Wenzel SE. Recent asthma exacerbations: a key predictor of future exacerbations. Respir Med 2007; 101: 481-489
  • 123 Ng TP, Lim TK, Abisheganaden J, Eng P, Sin FL. Factors associated with acute health care use in a national adult asthma management program. Ann Allergy Asthma Immunol 2006; 97: 784-793
  • 124 Lin YH, Tsai CL, Chien LN, Chiou HY, Jeng C. Newly diagnosed gastroesophageal reflux disease increased the risk of acute exacerbation of chronic obstructive pulmonary disease during the first year following diagnosis – a nationwide population-based cohort study. Int J Clin Pract 2014;
  • 125 Kapadia SG, Wei C, Bartlett SJ et al. Obesity and symptoms of depression contribute independently to the poor asthma control of obesity. Respir Med 2014; 108: 1100-1107
  • 126 Koo HK, Park JH, Park HK, Jung H, Lee SS. Conflicting role of sarcopenia and obesity in male patients with chronic obstructive pulmonary disease: korean national health and nutrition examination survey. PLoS One 2014; 9: e110448
  • 127 Griswold SK, Nordstrom CR, Clark S et al. Asthma exacerbations in North American adults: who are the “frequent fliers” in the emergency department?. Chest 2005; 127: 1579-1586
  • 128 Parreira VF, Kirkwood R, Towns M et al. Is there an association between symptoms of anxiety and depression and quality of life in patients with chronic obstructive pulmonary disease?. Can Respir J 2014;
  • 129 Blumstein GI, Tuft L. Allergy treatment in recurrent nasal polyposis: its importance and value. The American journal of the medical sciences 1957; 234: 269-280
  • 130 Drake-Lee AB. Histamine and its release from nasal polyps: preliminary communication. J R Soc Med 1984; 77: 120-124
  • 131 Canuel M, Lebel G. Epidemiology of allergic rhinitis in Quebec: from a 2008 population-based survey. Chronic Dis Inj Can 2014; 34: 163-168
  • 132 Benninger M. Rhinitis, sinusitis and their relationships to allergies. Am j Rhinol 1992; 6: 37-43
  • 133 Emanuel IA, Shah SB. Chronic rhinosinusitis: allergy and sinus computed tomography relationships. Otolaryngol Head Neck Surg 2000; 123: 687-691
  • 134 Grove R. Chronic hyperplastic sinusitis in allergic patients: a bacteriologic study of 200 operative cases. The Journal of allergy and clinical immunology 1990; 11: 271-276
  • 135 Savolainen S. Allergy in patients with acute maxillary sinusitis. Allergy 1989; 44: 116-122
  • 136 Bachert C, Gevaert P, Holtappels G, Johansson SG, van Cauwenberge P. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol 2001; 107: 607-614
  • 137 Bachert C, van Cauwenberge P, Olbrecht J, van Schoor J. Prevalence, classification and perception of allergic and nonallergic rhinitis in Belgium. Allergy 2006; 61: 693-698
  • 138 Lane AP, Pine HS, Pillsbury 3rd HC. Allergy testing and immunotherapy in an academic otolaryngology practice: a 20-year review. Otolaryngol Head Neck Surg 2001; 124: 9-15
  • 139 Benoliel P. Traitement d’une polypose nasosinusienne (PNS) par immunotherapie au Candida albicans: a propos de 4 cas. Allerg Immunol (Paris) 2001; 33: 388-394
  • 140 Karlsson G, Holmberg K. Does allergic rhinitis predispose to sinusitis?. Acta Otolaryngol Suppl 1994; 515: 26-28 discussion 29
  • 141 Hamilos DL, Leung DY, Wood R et al. Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. The Journal of allergy and clinical immunology 1995; 96: 537-544
  • 142 Slavin RG. Sinusitis in adults and its relation to allergic rhinitis, asthma, and nasal polyps. The Journal of allergy and clinical immunology 1988; 82: 950-956
  • 143 Shapiro GG. Role of allergy in sinusitis. Pediatr Infect Dis 1985; 4: S55-S59
  • 144 Caplin I, Haynes JT, Spahn J. Are nasal polyps an allergic phenomenon?. Ann Allergy 1971; 29: 631-634
  • 145 Bunnag C, Pacharee P, Vipulakom P, Siriyananda C. A study of allergic factor in nasal polyp patients. Ann Allergy 1983; 50: 126-132
  • 146 Pang YT, Eskici O, Wilson JA. Nasal polyposis: role of subclinical delayed food hypersensitivity. Otolaryngol Head Neck Surg 2000; 122: 298-301
  • 147 Wilson KF, McMains KC, Orlandi RR. The association between allergy and chronic rhinosinusitis with and without nasal polyps: an evidence-based review with recommendations. International forum of allergy & rhinology 2014; 4: 93-103
  • 148 Hirschberg . Anaphylactoid reaction to aspirin (1902). Allergy Proc 1990; 11: 249-250 discussion 251–252
  • 149 Widal F, Abrami P, Lermoyez J. Anaphylaxie et idiosyncrasie. 1992. Allergy Proc 1993; 14: 373-376 discussion 371–372
  • 150 Samter M, Beers Jr RF. Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Annals of internal medicine 1968; 68: 975-983
  • 151 Szczeklik A, Nizankowska E, Duplaga M. Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma. Eur Respir J 2000; 16: 432-436
  • 152 Berges-Gimeno MP, Simon RA, Stevenson DD. The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol 2002; 89: 474-478
  • 153 Settipane GA, Chafee FH, Klein DE. Aspirin intolerance. II. A prospective study in an atopic and normal population. The Journal of allergy and clinical immunology 1974; 53: 200-204
  • 154 Vally H, Taylor ML, Thompson PJ. The prevalence of aspirin intolerant asthma (AIA) in Australian asthmatic patients. Thorax 2002; 57: 569-574
  • 155 Bochenek G, Nizankowska E, Szczeklik A. The atopy trait in hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy 1996; 51: 16-23
  • 156 Stevenson DD. Diagnosis, prevention, and treatment of adverse reactions to aspirin and nonsteroidal anti-inflammatory drugs. The Journal of allergy and clinical immunology 1984; 74: 617-622
  • 157 Kalyoncu AF, Karakaya G, Sahin AA, Baris YI. Occurrence of allergic conditions in asthmatics with analgesic intolerance. Allergy 1999; 54: 428-435
  • 158 Jenkins C, Costello J, Hodge L. Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice. BMJ 2004; 328: 434
  • 159 Garcia Cruz ML, Jimenez-Chobillon MA, Teran LM. Rhinosinusitis and aspirin-exacerbated respiratory disease. J Allergy (Cairo) 2012; 2012 273752
  • 160 Kim JE, Kountakis SE. The prevalence of Samter’s triad in patients undergoing functional endoscopic sinus surgery. Ear, nose, & throat journal 2007; 86: 396-399
  • 161 Chang JE, White A, Simon RA, Stevenson DD. Aspirin-exacerbated respiratory disease: burden of disease. Allergy and asthma proceedings: the official journal of regional and state allergy societies 2012; 33: 117-121
  • 162 Kim JY, Kim JH, Park TJ et al. Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. BMC Pulm Med 2010; 10: 34
  • 163 Kim SH, Kim YK, Park HW et al. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. Respir Med 2009; 103: 356-363
  • 164 Kim SH, Kim YK, Park HW et al. Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Pharmacogenet Genomics 2007; 17: 295-304
  • 165 Kim SH, Ye YM, Hur GY et al. CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. Pharmacogenomics 2007; 8: 1143-1150
  • 166 Kim SH, Yang EM, Lee HN et al. Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis. Allergy 2009; 64: 1221-1225
  • 167 Kim TH, Chang HS, Park SM et al. Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics. Clin Exp Allergy 2008; 38: 1727-1737
  • 168 Palikhe NS, Kim SH, Cho BY et al. Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma. Respir Med 2008; 102: 1132-1139
  • 169 Chang JE, Ding D, Martin-Lazaro J, White A, Stevenson DD. Smoking, environmental tobacco smoke, and aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol 2012; 108: 14-19
  • 170 RKI . Gesundheit in Deutschland. Gesundheitsberichterstattung des Bundes 2006;
  • 171 Masi AT, Hunder GG, Lie JT et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis and rheumatism 1990; 33: 1094-1100
  • 172 Mahr A, Guillevin L, Poissonnet M, Ayme S. Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener’s granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate. Arthritis and rheumatism 2004; 51: 92-99
  • 173 Martin RM, Wilton LV, Mann RD. Prevalence of Churg-Strauss syndrome, vasculitis, eosinophilia and associated conditions: retrospective analysis of 58 prescription-event monitoring cohort studies. Pharmacoepidemiol Drug Saf 1999; 8: 179-189
  • 174 Mohammad AJ, Jacobsson LT, Mahr AD, Sturfelt G, Segelmark M. Prevalence of Wegener’s granulomatosis, microscopic polyangiitis, polyarteritis nodosa and Churg-Strauss syndrome within a defined population in southern Sweden. Rheumatology (Oxford) 2007; 46: 1329-1337
  • 175 Loughlin JE, Cole JA, Rothman KJ, Johnson ES. Prevalence of serious eosinophilia and incidence of Churg-Strauss syndrome in a cohort of asthma patients. Ann Allergy Asthma Immunol 2002; 88: 319-325
  • 176 Ribi C, Cohen P, Pagnoux C et al. Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patients. Arthritis and rheumatism 2008; 58: 586-594
  • 177 Pagnoux C. Churg-Strauss syndrome: evolving concepts. Discov Med 2010; 9: 243-252
  • 178 Srouji I, Lund V, Andrews P, Edwards C. Rhinologic symptoms and quality-of-life in patients with Churg-Strauss syndrome vasculitis. Am J Rhinol 2008; 22: 406-409
  • 179 Sinico RA, Di Toma L, Maggiore U et al. Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome. Arthritis and rheumatism 2005; 52: 2926-2935
  • 180 Bacciu A, Buzio C, Giordano D et al. Nasal polyposis in Churg-Strauss syndrome. The Laryngoscope 2008; 118: 325-329
  • 181 Samson M, Puechal X, Devilliers H et al. Long-term outcomes of 118 patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) enrolled in two prospective trials. J Autoimmun 2013; 43: 60-69
  • 182 Morinaka S, Ichimiya M, Nakamura H. Detection of Helicobacter pylori in nasal and maxillary sinus specimens from patients with chronic sinusitis. The Laryngoscope 2003; 113: 1557-1563
  • 183 Flook EP, Kumar BN. Is there evidence to link acid reflux with chronic sinusitis or any nasal symptoms? A review of the evidence. Rhinology 2011; 49: 11-16
  • 184 Pasic TR, Palazzi-Churas KL, Connor NP, Cohen SB, Leverson GE. Association of extraesophageal reflux disease and sinonasal symptoms: prevalence and impact on quality of life. The Laryngoscope 2007; 117: 2218-2228
  • 185 Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Archives of otolaryngology – head & neck surgery 2000; 126: 831-836
  • 186 El-Serag HB, Gilger M, Kuebeler M, Rabeneck L. Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology 2001; 121: 1294-1299
  • 187 Yuksel F, Dogan M, Karatas D et al. Gastroesophageal reflux disease in children with chronic otitis media with effusion. J Craniofac Surg 2013; 24: 380-383
  • 188 Bothwell MR, Parsons DS, Talbot A, Barbero GJ, Wilder B. Outcome of reflux therapy on pediatric chronic sinusitis. Otolaryngol Head Neck Surg 1999; 121: 255-262
  • 189 Barbero GJ. Gastroesophageal reflux and upper airway disease. Otolaryngologic clinics of North America 1996; 29: 27-38
  • 190 Suskind DL, Zeringue 3rd GP, Kluka EA, Udall J, Liu DC. Gastroesophageal reflux and pediatric otolaryngologic disease: the role of antireflux surgery. Archives of otolaryngology – head & neck surgery 2001; 127: 511-514
  • 191 Lund VJ, Stammberger H, Fokkens WJ et al. European position paper on the anatomical terminology of the internal nose and paranasal sinuses. Rhinol Suppl 2014; 1-34
  • 192 Yasan H, Dogru H, Baykal B, Doner F, Tuz M. What is the relationship between chronic sinus disease and isolated nasal septal deviation?. Otolaryngol Head Neck Surg 2005; 133: 190-193
  • 193 Calhoun KH, Waggenspack GA, Simpson CB, Hokanson JA, Bailey BJ. CT evaluation of the paranasal sinuses in symptomatic and asymptomatic populations. Otolaryngol Head Neck Surg 1991; 104: 480-483
  • 194 Kayalioglu G, Oyar O, Govsa F. Nasal cavity and paranasal sinus bony variations: a computed tomographic study. Rhinology 2000; 38: 108-113
  • 195 Jones NS, Strobl A, Holland I. A study of the CT findings in 100 patients with rhinosinusitis and 100 controls. Clinical otolaryngology and allied sciences 1997; 22: 47-51
  • 196 Perez P, Sabate J, Carmona A, Catalina-Herrera C, Jimenez-Castellanos J. Anatomical variations in the human paranasal sinus region studied by CT. Journal of anatomy 2000; 197: 221-227
  • 197 Holbrook EH, Brown CL, Lyden ER, Leopold DA. Lack of significant correlation between rhinosinusitis symptoms and specific regions of sinus computer tomography scans. American journal of rhinology 2005; 19: 382-387
  • 198 Nouraei SA, Elisay AR, Dimarco A et al. Variations in paranasal sinus anatomy: implications for the pathophysiology of chronic rhinosinusitis and safety of endoscopic sinus surgery. Journal of otolaryngology – head & neck surgery=Le Journal d’oto-rhino-laryngologie et de chirurgie cervico-faciale 2009; 38: 32-37
  • 199 Jones NS. CT of the paranasal sinuses: a review of the correlation with clinical, surgical and histopathological findings. Clinical otolaryngology and allied sciences 2002; 27: 11-17
  • 200 Willner A, Choi SS, Vezina LG, Lazar RH. Intranasal anatomic variations in pediatric sinusitis. American journal of rhinology 1997; 11: 355-360
  • 201 Clark S, Babin R, Salazar J. The Incidence of Concha Bullosa and Its Relationship to Chronic Sinonasal Disease. Am j Rhinol 1989; 2: 11-12
  • 202 Stallman JS, Lobo JN, Som PM. The incidence of concha bullosa and its relationship to nasal septal deviation and paranasal sinus disease. AJNR Am J Neuroradiol 2004; 25: 1613-1618
  • 203 Sedaghat AR, Gray ST, Chambers KJ, Wilke CO, Caradonna DS. Sinonasal anatomic variants and asthma are associated with faster development of chronic rhinosinusitis in patients with allergic rhinitis. International forum of allergy & rhinology 2013; 3: 755-761
  • 204 Bolger WE, Butzin CA, Parsons DS. Paranasal sinus bony anatomic variations and mucosal abnormalities: CT analysis for endoscopic sinus surgery. The Laryngoscope 1991; 101: 56-64
  • 205 Caspar A. Häufigkeit von krankhaften Veränderungen im Bereich der Nasennebenhöhlen. Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsmedizin Greifswald 2015;
  • 206 el-Hakim H, Oluwole M, MacKerrow WS, McClymont LG, White PS. Study of surgeons’ agreement on the presence of bony anomalies on coronal CT of paranasal sinuses. Ear, nose, & throat journal 2002; 81: 834-838
  • 207 Hur K, Liang J, Lin SY. The role of secondhand smoke in sinusitis: a systematic review. International forum of allergy & rhinology 2014; 4: 22-28
  • 208 Wentzel JL, Mulligan JK, Soler ZM, White DR, Schlosser RJ. Passive smoke exposure in chronic rhinosinusitis as assessed by hair nicotine. American journal of rhinology & allergy 2014; 28: 297-301
  • 209 Ebbert JO, Croghan IT, Schroeder DR, Murawski J, Hurt RD. Association between respiratory tract diseases and secondhand smoke exposure among never smoking flight attendants: a cross-sectional survey. Environ Health 2007; 6: 28
  • 210 Ferguson BJ, Rubinstein E. In reference to The role of allergy and smoking in chronic rhinosinusitis and polyposis. The Laryngoscope 2009; 119 1448; author reply 1449-1451
  • 211 Nair S. In reference to The role of allergy and smoking in chronic rhinosinusitis and polyposis. The Laryngoscope 2009; 119: 617
  • 212 Houser SM, Keen KJ. In response to The role of allergy and smoking in chronic rhinosinusitis and polyposis (Laryngoscope, 118: 1521-1527, 2008). The Laryngoscope 2009; 119: 616
  • 213 Houser SM, Keen KJ. The role of allergy and smoking in chronic rhinosinusitis and polyposis. The Laryngoscope 2008; 118: 1521-1527
  • 214 Lachanas VA, Tsea M, Tsiouvaka S et al. The effect of active cigarette smoking on Sino-Nasal Outcome Test in 127 subjects without rhinologic disease. A prospective study. Clin Otolaryngol. 2014
  • 215 Thilsing T, Rasmussen J, Lange B et al. Chronic rhinosinusitis and occupational risk factors among 20- to 75-year-old Danes-A GA(2) LEN-based study. Am J Ind Med 2012; 55: 1037-1043
  • 216 Radon K, Schulze A, Strien R et al. Prevalence of respiratory symptoms and diseases in neighbours of large-scale farming in Northern Germany. Pneumologie 2005; 59: 897-900
  • 217 May S, Romberger DJ, Poole JA. Respiratory health effects of large animal farming environments. J Toxicol Environ Health B Crit Rev 2012; 15: 524-541
  • 218 McElroy KG. Environmental health effects of concentrated animal feeding operations: implications for nurses. Nurs Adm Q 2010; 34: 311-319
  • 219 Iversen M, Kirychuk S, Drost H, Jacobson L. Human health effects of dust exposure in animal confinement buildings. J Agric Saf Health 2000; 6: 283-288
  • 220 Webber MP, Glaser MS, Weakley J et al. Physician-diagnosed respiratory conditions and mental health symptoms 7–9 years following the World Trade Center disaster. Am J Ind Med 2011; 54: 661-671
  • 221 Kim J, Hanley JA. The role of woodstoves in the etiology of nasal polyposis. Archives of otolaryngology – head & neck surgery 2002; 128: 682-686
  • 222 Koh DH, Kim HR, Han SS. The relationship between chronic rhinosinusitis and occupation: the 1998, 2001, and 2005 Korea National health and nutrition examination survey (KNHANES). Am J Ind Med 2009; 52: 179-184
  • 223 Kilty SJ, McDonald JT, Johnson S, Al-Mutairi D. Socioeconomic status: a disease modifier of chronic rhinosinusitis?. Rhinology 2011; 49: 533-537
  • 224 Beaglehole R, Magnus P. The search for new risk factors for coronary heart disease: occupational therapy for epidemiologists?. International journal of epidemiology 2002; 31: 1117-1122 author reply 1134–1135
  • 225 Wang PC, Lin HC, Kang JH. Chronic rhinosinusitis confers an increased risk of acute myocardial infarction. American journal of rhinology & allergy 2013; 27: e178-e182
  • 226 Hao WR, Lin HW, Chao PZ et al. Risk of myocardial infarction in patients with rhinosinusitis. Atherosclerosis 2013; 226: 263-268
  • 227 Wu CW, Chao PZ, Hao WR, Liou TH, Lin HW. Risk of stroke among patients with rhinosinusitis: a population-based study in Taiwan. American journal of rhinology & allergy 2012; 26: 278-282
  • 228 Kang JH, Wu CS, Keller JJ, Lin HC. Chronic rhinosinusitis increased the risk of stroke: a 5-year follow-up study. The Laryngoscope 2013; 123: 835-840
  • 229 Bhattacharyya N. Associations between obesity and inflammatory sinonasal disorders. The Laryngoscope 2013; 123: 1840-1844
  • 230 Chung SD, Chen PY, Lin HC, Hung SH. Comorbidity profile of chronic rhinosinusitis: a population-based study. The Laryngoscope 2014; 124: 1536-1541
  • 231 Brandsted R, Sindwani R. Impact of depression on disease-specific symptoms and quality of life in patients with chronic rhinosinusitis. Am j Rhinol 2007; 21: 50-54
  • 232 Macdonald KI, McNally JD, Massoud E. The health and resource utilization of Canadians with chronic rhinosinusitis. The Laryngoscope 2009; 119: 184-189
  • 233 Wasan A, Fernandez E, Jamison RN, Bhattacharyya N. Association of anxiety and depression with reported disease severity in patients undergoing evaluation for chronic rhinosinusitis. The Annals of otology, rhinology, and laryngology 2007; 116: 491-497
  • 234 Chee L, Graham SM, Carothers DG, Ballas ZK. Immune dysfunction in refractory sinusitis in a tertiary care setting. The Laryngoscope 2001; 111: 233-235
  • 235 Kim RJ, Yin T, Chen CJ et al. The interaction between bacteria and mucosal immunity in chronic rhinosinusitis: a prospective cross-sectional analysis. American journal of rhinology & allergy 2013; 27: e183-e189
  • 236 Alqudah M, Graham SM, Ballas ZK. High prevalence of humoral immunodeficiency patients with refractory chronic rhinosinusitis. American journal of rhinology & allergy 2010; 24: 409-412
  • 237 Carr TF, Koterba AP, Chandra R et al. Characterization of specific antibody deficiency in adults with medically refractory chronic rhinosinusitis. American journal of rhinology & allergy 2011; 25: 241-244
  • 238 Vanlerberghe L, Joniau S, Jorissen M. The prevalence of humoral immunodeficiency in refractory rhinosinusitis: a retrospective analysis. B-Ent 2006; 2: 161-166
  • 239 Cheng YK, Decker PA, O’Byrne MM, Weiler CR. Clinical and laboratory characteristics of 75 patients with specific polysaccharide antibody deficiency syndrome. Ann Allergy Asthma Immunol 2006; 97: 306-311
  • 240 Kim JH, Kim GE, Cho GS et al. Natural killer cells from patients with chronic rhinosinusitis have impaired effector functions. PLoS One 2013; 8: e77177
  • 241 Porter JP, Patel AA, Dewey CM, Stewart MG. Prevalence of sinonasal symptoms in patients with HIV infection. American journal of rhinology 1999; 13: 203-208
  • 242 Garcia-Rodriguez JF, Corominas M, Fernandez-Viladrich P, Monfort JL, Dicenta M. Rhinosinusitis and atopy in patients infected with HIV. The Laryngoscope 1999; 109: 939-944
  • 243 Miziara ID, Araujo Filho BC, La Cortina RC, Romano FR, Lima AS. Chronic rhinosinusitis in HIV-infected patients: radiological and clinical evaluation. Braz J Otorhinolaryngol 2005; 71: 604-608
  • 244 Nzuzi KP, Longo-Mbenza B, Matanda Nzanza R, Nge Okwe A, Mbungu Fuele S. L’infection a VIH/SIDA exerce t-elle un role independant dans la genese de rhinosinusite chronique en Afrique Centrale?. Rev Laryngol Otol Rhinol (Bord) 2010; 131: 247-251
  • 245 Pinheiro Neto CD, Weber R, Araujo-Filho BC, Miziara ID. Rhinosinusitis in HIV-infected children undergoing antiretroviral therapy. Braz J Otorhinolaryngol 2009; 75: 70-75
  • 246 Moon BJ, Han JH, Jang YJ, Lee BJ, Chung YS. Effect of chronic rhinosinusitis on liver transplant patients. American journal of rhinology & allergy 2009; 23: 492-496
  • 247 Chen CY, Sheng WH, Cheng A et al. Invasive fungal sinusitis in patients with hematological malignancy: 15 years experience in a single university hospital in Taiwan. BMC infectious diseases 2011; 11: 250
  • 248 Lee SY, Yeo CL, Lee WH et al. Prevalence of invasive fungal disease in hematological patients at a tertiary university hospital in Singapore. BMC research notes 2011; 4: 42
  • 249 Blyth CC, Gomes L, Sorrell TC et al. Skull-base osteomyelitis: fungal vs. bacterial infection. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2011; 17: 306-311
  • 250 Chung SD, Hung SH, Lin HC, Lin CC. Health care service utilization among patients with chronic rhinosinusitis: a population-based study. The Laryngoscope 2014; 124: 1285-1289
  • 251 Tsou YA, Lin CC, Tai CJ et al. Chronic rhinosinusitis and the risk of nasopharyngeal cancer in a Taiwanese health study. American journal of rhinology & allergy 2014; 28: 168-172
  • 252 Hung SH, Chen PY, Lin HC, Ting J, Chung SD. Association of rhinosinusitis with nasopharyngeal carcinoma: a population-based study. The Laryngoscope 2014; 124: 1515-1520
  • 253 Ray NF, Baraniuk JN, Thamer M et al. Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders. The Journal of allergy and clinical immunology 1999; 103: 408-414
  • 254 Bhattacharyya N. Contemporary assessment of the disease burden of sinusitis. American journal of rhinology & allergy 2009; 23: 392-395
  • 255 Murphy MP, Fishman P, Short SO et al. Health care utilization and cost among adults with chronic rhinosinusitis enrolled in a health maintenance organization. Otolaryngol Head Neck Surg 2002; 127: 367-376
  • 256 Burt C, McCaig L, Rechtsteiner E. Ambulatory medicalcare utilization estimates for 2005. Hyattsville 2007;
  • 257 Schappert S. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1997 National Center for Health Statistics. Vital Health Stat 10 1999; 10: 13
  • 258 Schappert SM, Burt CW. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001–02. Vital Health Stat 13 2006; 1-66
  • 259 Cherry D, Burt C, Woodwell D. National Ambulatory Medical Care Survey: 2001 summary. Hyattsville, Maryland 2003;
  • 260 Bhattacharyya N. The economic burden and symptom manifestations of chronic rhinosinusitis. Am j Rhinol 2003; 17: 27-32
  • 261 Gwaltney Jr JM, Jones JG, Kennedy DW. Medical management of sinusitis: educational goals and management guidelines. The International Conference on sinus Disease. Ann Otol Rhinol Laryngol Suppl 1995; 167: 22-30
  • 262 Bhattacharyya N. Incremental health care utilization and expenditures for chronic rhinosinusitis in the United States. Ann Otol Rhinol Laryngol 2011; 120: 423-427
  • 263 Bhattacharyya N. Functional limitations and workdays lost associated with chronic rhinosinusitis and allergic rhinitis. American journal of rhinology & allergy 2012; 26: 120-122
  • 264 Pleis JR, Coles R. Summary health statistics for US adults: National Health Interview Survey, 1998. Vital Health Stat 2002; 10: 1-113
  • 265 Pleis JR, Coles R. Summary health statistics for US adults: National Health Interview Survey, 1999. Vital Health Stat 2003; 10: 1-137
  • 266 Pleis JR, Schiller JS, Benson V. Summary health statistics for US adults: National Health Interview Survey, 2000. Vital Health Stat 2003; 10: 1-132
  • 267 Lucas JW, Schiller JS, Benson V. Summary health statistics for US adults: National Health Interview Survey, 2001. Vital Health Stat 2004; 10: 1-134
  • 268 Lethbridge-Cejku M, Schiller JS, Bernadel L.. Summary health statistics for US adults: National Health Interview Survey, 2002. Vital Health Stat 2004; 10: 1-151
  • 269 Lethbridge-Cejku M, Vickerie J. Summary health statistics for US Adults: national health interview survey, 2003. Vital Health Stat 2005; 10: 1-161
  • 270 Lethbridge-Cejku M, Rose D, Vickerie J. Summary health statistics for US Adults: national health interview survey, 2004. Vital Health Stat 2006; 10: 1-164
  • 271 Pleis JR, Lethbridge-Cejku M. Summary health statistics for US adults: National Health Interview Survey, 2005. Vital Health Stat 2006; 10: 1-153
  • 272 Pleis JR, Lethbridge-Cejku M. Summary health statistics for US adults: National Health Interview Survey, 2006. Vital Health Stat 2007; 10: 1-153
  • 273 Pleis JR, Lucas JW. Summary health statistics for US adults: National Health Interview Survey, 2007. Vital Health Stat 2009; 10: 1-159
  • 274 Pleis J, Lucas J, Ward B. Summary health statistics for US adults: National Health Interview Survey, 2008. Vital Health Stat 2009; 10
  • 275 Schiller JS, Lucas JW, Ward BW, Peregoy JA. Summary health statistics for US adults: National Health Interview Survey, 2010. Vital Health Stat 2012; 10: 1-207
  • 276 Schiller JS, Lucas JW, Peregoy JA. Summary health statistics for US Adults: national health interview survey, 2011. Vital Health Stat 2012; 10: 1-218
  • 277 Blackwell DL, Lucas JW, Clarke TC. Summary health statistics for US adults: national health interview survey, 2012. Vital Health Stat 2014; 10: 1-161
  • 278 Ahsan SF, Jumans S, Nunez DA. Chronic rhinosinusitis: a comparative study of disease occurrence in North of Scotland and Southern Caribbean otolaryngology outpatient clinics over a two month period. Scott Med J 2004; 49: 130-133
  • 279 Shashy RG, Moore EJ, Weaver A. Prevalence of the chronic sinusitis diagnosis in Olmsted County, Minnesota. Archives of otolaryngology – head & neck surgery 2004; 130: 320-323
  • 280 Newton JR, Ah-See KW. A review of nasal polyposis. Ther Clin Risk Manag 2008; 4: 507-512
  • 281 Bavbek S, Dursun B, Dursun E, Korkmaz H, Sertkaya Karasoy D. The prevalence of aspirin hypersensitivity in patients with nasal polyposis and contributing factors. American journal of rhinology & allergy 2011; 25: 411-415
  • 282 Bavbek S, Yilmaz I, Celik G et al. Prevalence of aspirin-exacerbated respiratory disease in patients with asthma in Turkey: a cross-sectional survey. Allergol Immunopathol (Madr) 2012; 40: 225-230
  • 283 Nabavi M, Esmaeilzadeh H, Arshi S et al. Aspirin hypersensitivity in patients with chronic rhinosinusitis and nasal polyposis: frequency and contributing factors. American journal of rhinology & allergy 2014; 28: 239-243
  • 284 Schappert S. National Ambulatory Medical Care Survey: 1991 summary. Hyattsville, Maryland 1993;
  • 285 Schappert S. National Ambulatory Medical Care Survey: 1992 summary. Hyattsville, Maryland 1994;
  • 286 Woodwell D, Schappert S. National Ambulatory Medical Care Survey: 1993 summary. Hyattsville, Maryand 1995;
  • 287 Schappert S. National Ambulatory Medical Care Survey: 1994 summary. Hyattsville, Maryland 1996;
  • 288 Woodwell D. National Ambulatory Medical Care Survey: 1995 Summary. Hyattsville, Maryland 1997;
  • 289 Woodwell D. National Ambulatory Medical Care Survey: 1996 Summary. Hyattsville, Maryland 1997;
  • 290 Woodwell D. National Ambulatory Medical Care Survey: 1997 Summary. Hyattsville, Maryland 1999;
  • 291 Woodwell D. National Ambulatory Medical Care Survey: 1998 Summary. Hyattsville, Maryland 2000;
  • 292 Cherry D, Burt C, Woodwell D. National Ambulatory Medical Care Survey: 1999 summary. Hyattsville, Maryland 2001;
  • 293 Cherry D, Woodwell D. National Ambulatory Medical Care Survey: 2000 summary. Hyattsville, Maryland 2002;
  • 294 Woodwell D, Cherry D. National Ambulatory Medical Care Survey: 2002 Summary. Hyattsville, Maryland; 2004
  • 295 Hing E, Cherry D, Woodwell D. National Ambulatory Medical Care Survey: 2003 summary. Hyattsville, MD 2005;
  • 296 Hing E, Cherry D, Woodwell D. National Ambulatory Medical Care Survey: 2004 summary. Hyattsville, MD 2006;
  • 297 Cherry DK, Woodwell DA, Rechtsteiner EA. National Ambulatory Medical Care Survey: 2005 summary. Advance data and statistics 2007; 1-39
  • 298 Cherry DK, Hing E, Woodwell DA, Rechtsteiner EA. National Ambulatory Medical Care Survey: 2006 summary. Natl Health Stat Report 2008; 1-39
  • 299 Centers for Disease Control and Prevention NCfHS. National Ambulatory Medical Care Survey: 2008 Summary Tables. 2010
  • 300 Centers for Disease Control and Prevention NCfHS. National Ambulatory Medical Care Survey: 2009 Summary Tables. 2012