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Horm Metab Res 2015; 47(04): 297-302
DOI: 10.1055/s-0034-1398663
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Short-Term Effect of Gastric Resection on Circulating Levels of Ghrelin, Peptide YY3–36 and Obestatin in Patients with Early Gastric Cancer

Authors

  • T. Y. Jeon

    1   Department of Surgery, Pusan National University School of Medicine, Gyeongsangnam-do, South Korea

  • S. Y. Lee

    2   Medical Education Unit and Medical Research Institute, Pusan National University School of Medicine, Gyeongsangnam-do, South Korea
    3   Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, South Korea

  • H. H. Kim

    4   Department of Laboratory Medicine, Pusan National University Hospital, Busan, South Korea

  • Y. H. Cho

    3   Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, South Korea

  • A. R. Cho

    3   Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, South Korea
Further Information

Publication History

received 23 April 2014

accepted 12 January 2015

Publication Date:
26 February 2015 (online)

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Abstract

The short-term responses of gut hormones and the compensative interaction during a one-week period after subtotal gastrectomy in early gastric cancer (EGC) patients were assessed. Previous studies have reported gut hormonal changes after Roux-en-Y gastric bypass surgery. Blood samples were collected from 40 patients with EGC preoperatively, at 1 h after gastric resection, and on postoperative day (POD) 1, 3, and 7. Levels of active ghrelin, total ghrelin, obestatin, and PYY3-36 were measured. Total ghrelin level rapidly reached a nadir of 69.1%, while active ghrelin level had increased to 135.5% at 1 h after resection. Then, both returned to preoperative level. On the contrary, active/total ghrelin reached its nadir quickly at 1 h after resection and had returned to the preoperative level by POD 3. The nadir PYY3-36 level was 71.4% on POD 1, followed by a gradual recovery, and had increased to 116.5% by POD 7. The same pattern was observed for obestatin. Active ghrelin/obestatin showed an increase on POD 1 while total ghrelin/obestatin showed a decrease on POD 3. Then, both returned to preoperative level. These results suggest that a rapid interactive compensatory mechanism of gut hormones does exist in the remnant gastrointestinal tract after abrupt changes in the production reservoir in nonobese people.

Key words

ghrelin - peptide YY3-36 - obestatin - stomach - gastrectomy