Hereditary and Acquired Polyneuropathy Conditions of the Peripheral Nerves: Clinical Considerations and MR Neurography Imaging

Abstract

Polyneuropathies can be classified as either primarily demyelinating or axonal, and further as hereditary or acquired. It is important to recognize acquired neuropathies because some are amenable to treatment. Clinical findings and electrophysiology are used in the routine diagnosis of these conditions. Magnetic resonance neurography (MRN) is a helpful supplementary diagnostic tool. This article discusses the typical clinical findings, electrophysiology findings, and MRN appearances of common hereditary or acquired neuropathies such as chronic inflammatory demyelinating neuropathy, multifocal motor neuropathy, diabetic neuropathy, chemotherapy-induced neuropathy, and postsurgical neuropathy.

Keywords

acquired neuropathy - hereditary neuropathy - demyelinating - axonal - MRN

• References

• 1 Dimachkie MM, Barohn RJ, Katz J. Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants. Neurol Clin 2013; 31 (2) 533-555
• 2 Hattori N, Misu K, Koike H , et al. Age of onset influences clinical features of chronic inflammatory demyelinating polyneuropathy. J Neurol Sci 2001; 184 (1) 57-63
• 3 Joint Task Force of the EFNS and the PNS. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society—first revision. J Peripher Nerv Syst 2010; 15 (1) 1-9
• 4 Thawait SK, Chaudhry V, Thawait GK , et al. High-resolution MR neurography of diffuse peripheral nerve lesions. AJNR Am J Neuroradiol 2011; 32 (8) 1365-1372
• 5 Rajabally YA, Knopp MJ, Martin-Lamb D, Morlese J. Diagnostic value of MR imaging in the Lewis-Sumner syndrome: a case series. J Neurol Sci 2014; 342 (1–2) 182-185
• 6 Tanaka K, Mori N, Yokota Y, Suenaga T. MRI of the cervical nerve roots in the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy: a single-institution, retrospective case-control study. BMJ Open 2013; 3 (8) e003443
• 7 Sinclair CD, Miranda MA, Cowley P , et al. MRI shows increased sciatic nerve cross sectional area in inherited and inflammatory neuropathies. J Neurol Neurosurg Psychiatry 2011; 82 (11) 1283-1286
• 8 Adachi Y, Sato N, Okamoto T , et al. Brachial and lumbar plexuses in chronic inflammatory demyelinating polyradiculoneuropathy: MRI assessment including apparent diffusion coefficient. Neuroradiology 2011; 53 (1) 3-11
• 9 Gorson KC, Katz J. Chronic inflammatory demyelinating polyneuropathy. Neurol Clin 2013; 31 (2) 511-532
• 10 Dimachkie MM, Saperstein DS. Acquired immune demyelinating neuropathies. Continuum (Minneap Minn) 2014; 20 (5 Peripheral Nervous System Disorders): 1241-1260
• 11 Joint Task Force of the EFNS and the PNS. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society—first revision. J Peripher Nerv Syst 2010; 15 (4) 295-301
• 12 Briani C, Cacciavillani M, Lucchetta M, Cecchin D, Gasparotti R. MR neurography findings in axonal multifocal motor neuropathy. J Neurol 2013; 260 (9) 2420-2422
• 13 Basta I, Nikolić A, Apostolski S , et al. Diagnostic value of combined magnetic resonance imaging examination of brachial plexus and electrophysiological studies in multifocal motor neuropathy. Vojnosanit Pregl 2014; 71 (8) 723-729
• 14 Chalian M, Behzadi AH, Williams EH, Shores JT, Chhabra A. High-resolution magnetic resonance neurography in upper extremity neuropathy. Neuroimaging Clin N Am 2014; 24 (1) 109-125
• 15 Baets J, De Jonghe P, Timmerman V. Recent advances in Charcot-Marie-Tooth disease. Curr Opin Neurol 2014; 27 (5) 532-540
• 16 Saporta MA, Shy ME. Inherited peripheral neuropathies. Neurol Clin 2013; 31 (2) 597-619
• 17 Li J. Inherited neuropathies. Semin Neurol 2012; 32 (3) 204-214
• 18 De Smet K, De Maeseneer M, Talebian Yazdi A, Stadnik T, De Mey J. MRI in hypertrophic mono- and polyneuropathies. Clin Radiol 2013; 68 (3) 317-322
• 19 Ellegala DB, Monteith SJ, Haynor D, Bird TD, Goodkin R, Kliot M. Characterization of genetically defined types of Charcot-Marie-Tooth neuropathies by using magnetic resonance neurography. J Neurosurg 2005; 102 (2) 242-245
• 20 Chhabra A, Thakkar RS, Andreisek G , et al. Anatomic MR imaging and functional diffusion tensor imaging of peripheral nerve tumors and tumorlike conditions. AJNR Am J Neuroradiol 2013; 34 (4) 802-807
• 21 Kim KE. Characteristic features of hereditary neuropathy with liability to pressure palsy (HNPP) presenting with brachial plexopathy in soldiers. J Neurol Sci 2014; 346 (1–2) 174-177
• 22 Potulska-Chromik A, Sinkiewicz-Darol E, Ryniewicz B , et al. Clinical, electrophysiological, and molecular findings in early onset hereditary neuropathy with liability to pressure palsy. Muscle Nerve 2014; 50 (6) 914-918
• 23 Yurrebaso I, Casado OL, Barcena J, Perez de Nanclares G, Aguirre U. Clinical, electrophysiological and magnetic resonance findings in a family with hereditary neuropathy with liability to pressure palsies caused by a novel PMP22 mutation. Neuromuscul Disord 2014; 24 (1) 56-62
• 24 Topakian R, Wimmer S, Pischinger B, Pichler R. Hereditary neuropathy with liability to pressure palsies presenting with sciatic neuropathy. BMJ Case Rep 2014; 2014
• 25 Russell JW, Zilliox LA. Diabetic neuropathies. Continuum (Minneap Minn) 2014; 20 (5 Peripheral Nervous System Disorders): 1226-1240
• 26 Spallone V, Ziegler D, Freeman R , et al; Toronto Consensus Panel on Diabetic Neuropathy. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev 2011; 27 (7) 639-653
• 27 Singleton JR, Smith AG, Russell JW, Feldman EL. Microvascular complications of impaired glucose tolerance. Diabetes 2003; 52 (12) 2867-2873
• 28 Malik RA. Pathology of human diabetic neuropathy. Handb Clin Neurol 2014; 126: 249-259
• 29 Thakkar RS, Del Grande F, Thawait GK, Andreisek G, Carrino JA, Chhabra A. Spectrum of high-resolution MRI findings in diabetic neuropathy. AJR Am J Roentgenol 2012; 199 (2) 407-412
• 30 Pham M, Oikonomou D, Bäumer P , et al. Proximal neuropathic lesions in distal symmetric diabetic polyneuropathy: findings of high-resolution magnetic resonance neurography. Diabetes Care 2011; 34 (3) 721-723
• 31 Trivedi JR, Silvestri NJ, Wolfe GI. Treatment of painful peripheral neuropathy. Neurol Clin 2013; 31 (2) 377-403
• 32 Chan YC, Lo YL, Chan ES. Immunotherapy for diabetic amyotrophy. Cochrane Database Syst Rev 2012; 6: CD006521
• 33 Cavaletti G, Zanna C. Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicity. Eur J Cancer 2002; 38 (14) 1832-1837
• 34 Argyriou AA, Zolota V, Kyriakopoulou O, Kalofonos HP. Toxic peripheral neuropathy associated with commonly used chemotherapeutic agents. J BUON 2010; 15 (3) 435-446
• 35 Argyriou AA, Bruna J, Marmiroli P, Cavaletti G. Chemotherapy-induced peripheral neurotoxicity (CIPN): an update. Crit Rev Oncol Hematol 2012; 82 (1) 51-77
• 36 Miltenburg NC, Boogerd W. Chemotherapy-induced neuropathy: a comprehensive survey. Cancer Treat Rev 2014; 40 (7) 872-882
• 37 Schmitt S, Goldschmidt H, Storch-Hagenlocher B , et al. Inflammatory autoimmune neuropathy, presumably induced by bortezomib, in a patient suffering from multiple myeloma. Int J Hematol 2011; 93 (6) 791-794
• 38 Quintyne KI, Mainstone P, McNamara B, Boers P, Wallis F, Gupta RK. Profound and persistent painful paclitaxel peripheral neuropathy in a premenopausal patient. BMJ Case Rep 2011; 2011
• 39 Delanian S, Lefaix JL, Pradat PF. Radiation-induced neuropathy in cancer survivors. Radiother Oncol 2012; 105 (3) 273-282
• 40 Chhabra A, Thawait GK, Soldatos T , et al. High-resolution 3T MR neurography of the brachial plexus and its branches, with emphasis on 3D imaging. AJNR Am J Neuroradiol 2013; 34 (3) 486-497
• 41 Staff NP, Engelstad J, Klein CJ , et al. Post-surgical inflammatory neuropathy. Brain 2010; 133 (10) 2866-2880
• 42 Chhabra A, Descamps MJ, Weathermon A, Connell DA, Soldatos T. Neurological complications of foot and ankle surgery. Semin Musculoskelet Radiol 2012; 16 (3) 254-266