Semin Neurol 2015; 35(02): 139-144
DOI: 10.1055/s-0035-1547533
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Brain Death: The European Perspective

Giuseppe Citerio
1   Department of Health Science, University of Milan Bicocca, Monza, Italy
2   Division of Neurointensive care, Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy
,
Paul G. Murphy
3   Department of Neuroanaesthesia and Critical Care, The General Infirmary at Leeds, Leeds, United Kingdom
› Author Affiliations
Further Information

Publication History

Publication Date:
03 April 2015 (online)

Abstract

Some of the seminal steps toward the recognition and definition of brain death were European. There is a general consensus on both the medical concept of brain death in Europe as well as the minimum fundamental clinical standards that are required for its diagnosis—the absence of consciousness, brainstem reflexes, and the ability to breathe in the absence of reversible or confounding conditions. Two aspects of brain death determination are addressed in this article. The authors analyze how brain death is diagnosed across Europe, identifying both the similarities and differences that exist between countries (the latter mainly concerning ancillary tests, timing, and the number of physicians involved in the brain death determination). In addition, they describe the very considerable variations in when brain death determinations are made between and within individual European countries, and propose that they are due to differences in the end-of-life care practices in patients with irreversible brain injuries, medical attitudes, and organ donation practices. Although legislation is available to standardize the brain death diagnosis process in most individual European countries, there are still disparities across Europe as a whole. The current variation in practice makes a continental consensus for the definition of brain death imperative.

 
  • References

  • 1 Laureys S. Science and society: death, unconsciousness and the brain. Nat Rev Neurosci 2005; 6 (11) 899-909
  • 2 Youn TS, Greer DM. Brain death and management of a potential organ donor in the intensive care unit. Crit Care Clin 2014; 30 (4) 813-831
  • 3 Mollaret P, Goulon M. [The depassed coma (preliminary memoir)]. Rev Neurol (Paris) 1959; 101: 3-15
  • 4 Wertheimer P, Jouvet M, Descotes J. [Diagnosis of death of the nervous system in comas with respiratory arrest treated by artificial respiration]. Presse Med 1959; 67 (3) 87-88
  • 5 Settergren G. Brain death: an important paradigm shift in the 20th century. Acta Anaesthesiol Scand 2003; 47 (9) 1053-1058
  • 6 Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. A definition of irreversible coma. JAMA 1968; 205 (6) 337-340
  • 7 Guidelines for the determination of death. Report of the medical consultants on the diagnosis of death to the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. JAMA 1981; 246 (19) 2184-2186
  • 8 The Quality Standards Subcommittee of the American Academy of Neurology. Practice parameters for determining brain death in adults (summary statement). Neurology 1995; 45 (5) 1012-1014
  • 9 Pallis C. ABC of brain stem death. From brain death to brain stem death. Br Med J (Clin Res Ed) 1982; 285 (6353) 1487-1490
  • 10 Pallis C. ABC of brain stem death. Diagnosis of brain stem death—II. Br Med J (Clin Res Ed) 1982; 285 (6355) 1641-1644
  • 11 Pallis C. ABC of brain stem death. Pitfalls and safeguards. Br Med J (Clin Res Ed) 1982; 285 (6356) 1720-1722
  • 12 Pallis C. ABC of brain stem death. Prognostic significance of a dead brain stem. Br Med J (Clin Res Ed) 1983; 286 (6359) 123-124
  • 13 Pallis C. ABC of brain stem death. Reappraising death. Br Med J (Clin Res Ed) 1982; 285 (6352) 1409-1412
  • 14 Pallis C. ABC of brain stem death. The position in the USA and elsewhere. Br Med J (Clin Res Ed) 1983; 286 (6360) 209-210
  • 15 Shemie SD, Hornby L, Baker A , et al; The International Guidelines for Determination of Death phase 1 participants, in collaboration with the World Health Organization. International guideline development for the determination of death. Intensive Care Med 2014; 40 (6) 788-797
  • 16 Haupt WF, Rudolf J. European brain death codes: a comparison of national guidelines. J Neurol 1999; 246 (6) 432-437
  • 17 Wijdicks EFM. Brain death worldwide: accepted fact but no global consensus in diagnostic criteria. Neurology 2002; 58 (1) 20-25
  • 18 Wijdicks EFM. The transatlantic divide over brain death determination and the debate. Brain 2012; 135 (Pt 4) 1321-1331
  • 19 Da Silva IRF, Frontera JA. Worldwide barriers to organ donation. JAMA Neurol 2014;
  • 20 Varelas P. Brain death determination: still a lot to learn, still a lot to do…. Neurocrit Care 2014; 21 (3) 373-375
  • 21 Citerio G, Crippa IA, Bronco A, Vargiolu A, Smith M. Variability in brain death determination in Europe: looking for a solution. Neurocrit Care 2014; 21 (3) 376-382
  • 22 Council of Europe. Organ shortage: current status and strategies for improvement of organ donation - A European consensus document. 2007 Available from: https://www.edqm.eu/en/organ-transplantation-reports-73.html . Accessed February 13, 2015
  • 23 Sprung CL, Cohen SL, Sjokvist P , et al; Ethicus Study Group. End-of-life practices in European intensive care units: the Ethicus Study. JAMA 2003; 290 (6) 790-797
  • 24 Carlet J, Thijs LG, Antonelli M , et al. Challenges in end-of-life care in the ICU. Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003. Intensive Care Med 2004; 30 (5) 770-784
  • 25 Manara AR, Murphy PG, O'Callaghan G. Donation after circulatory death. Br J Anaesth 2012; 108 (Suppl. 01) i108-i121
  • 26 Sprung CL, Carmel S, Sjokvist P , et al; ETHICATT Study Group. Attitudes of European physicians, nurses, patients, and families regarding end-of-life decisions: the ETHICATT study. Intensive Care Med 2007; 33 (1) 104-110
  • 27 Lesieur O, Leloup M, Gonzalez F, Mamzer M-F. Eligibility for organ donation following end-of-life decisions: a study performed in 43 French intensive care units. Intensive Care Med 2014; 40 (9) 1323-1331
  • 28 Procaccio F, Rizzato L, Ricci A, Venettoni S, Nanni Costa A. Do “silent” brain deaths affect potential organ donation?. Transplant Proc 2010; 42 (6) 2190-2191
  • 29 Procaccio F, Ricci A, Ghirardini A , et al. Deaths with acute cerebral lesions in ICU: Does the number of potential organ donors depend on predictable factors?. Minerva Anestesiol 2014;
  • 30 Wesslau C, Grosse K, Krüger R , et al. How large is the organ donor potential in Germany? Results of an analysis of data collected on deceased with primary and secondary brain damage in intensive care unit from 2002 to 2005. Transpl Int 2007; 20 (2) 147-155
  • 31 Kosieradzki M, Jakubowska-Winecka A, Feliksiak M , et al. Attitude of healthcare professionals: a major limiting factor in organ donation from brain-dead donors. J Transplant 2014; 2014: 296912
  • 32 Rudge C, Matesanz R, Delmonico FL, Chapman J. International practices of organ donation. Br J Anaesth 2012; 108 (Suppl. 01) i48-i55
  • 33 Matesanz R, Coll E, Domínguez-Gil B , et al. Benchmarking in the process of donation after brain death: a methodology to identify best performer hospitals. Am J Transplant 2012; 12 (9) 2498-2506
  • 34 Wijdicks EFM, Varelas PN, Gronseth GS, Greer DM. ;American Academy of Neurology. Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010; 74 (23) 1911-1918
  • 35 Shemie SD, Baker A. Where have we been? Where are we going? Initiatives to improve uniformity of policies, integrity of practice, and improve understanding of brain death within the global medical community and lay public. J Crit Care 2014; 29 (6) 1114-1116