Early and Menopausal Weight Gain and its Relationship with the Development of Diabetes and Hypertension

Abstract

Background: Previous research has revealed a clear relationship between weight gain of persons and their metabolic diseases developing later. These studies have covered only short periods lasting 4–8 years.

Our goal was to collect decades’ old and often life-long anthropometric data and correlate the figures with the presence of hypertension and diabetes or both.

Methods: A retrospective international study was planned and organized to compare self-recorded data of lifelong weight gain among 60–70-year-old patients, analyze their correlation with metabolic diseases they developed, with special attention to women’s weight gain around pregnancy, delivery and menopause in primary care settings in Germany, Hungary, Italy, Slovakia and the Ukraine.

Results: Of the recruited 815 participants, 319 men and 496 women presented all the required data. Diabetics of both genders had the highest baseline weight at 20 years of age. The weight and BMI of the whole study population increased steadily until their seventies, but to a lesser extent after their fifties. Compared to the control group, changes over decades were the greatest among diabetics and also greater among patients with hypertension. Weight increase in the first decades (20–30-year-old men and 30–40-year-old women) was a significant risk factor for the development of diabetes (OR=1.044; p=0.002; 95% CI: 1.01–1.07). Among patients with diabetes and hypertension, both diagnoses were set up earlier than among those with a single morbidity.

Among females, weight increase around pregnancy and menopause correlated significantly with higher odds for the diagnoses of diabetes and/or hypertension, irrespective of the number of children.

Conclusions: During their decade-long relationship with their patients, family physicians are expected to identify the higher weight gain of their patients, especially among younger generation and intervene, if necessary.

Key words

diabetes - Germany - Hungary - hypertension - Italy - menopause - metabolic syndrome - obesity - primary care - Slovakia - the Ukraine - weight gain

^* Authors declare their equal contribution and both are considered as first author.

• References

• 1 Patel SR, Hu FB. Short sleep duration and weight gain: a systematic review. Obesity (Silver Spring) 2008; 16: 643-653
• 2 Alley DE, Chang VW. Metabolic syndrome and weight gain in adulthood. J Gerontol A Biol Sci Med Sci. 2010; 65: 111-117
• 3 Ferrara N, Corbi G, Scarpab D et al. The role of hypertension in metabolic syndrome. [in Italian] G Gerontol 2004; 52: 353-359
• 4 Mozaffarian D, Hao T, Rimm EB et al. Changes in diet and lifestyle and long-term weight gain in women and men. Engl J Med 2011; 364: 2392-2404
• 5 Pimenta AM, Beunza JJ, Sanchez-Villegas A et al. Childhood underweight, weight gain during childhood to adolescence/young adulthood and incidence of adult metabolic syndrome in the SUN (Seguimiento Universidad de Navarra) Project. Public Health Nutr 2011; 14: 1237-1244
• 6 Stefanska A, Sypniewska G, Blaszkiewicz B et al. Long-term weight gain and metabolic syndrome, adiponectin and C-reactive protein in women aged 50–60 years. Adv Med Sci 2010; 55: 186-190
• 7 Brillo E, Fiengo S, Romanelli M et al. Body mass index ed outcome ostetrico neonatale. Riv It Ost Gin. 2010. 26. 221
• 8 Simoncig-Netjasov A, Vujović S, Ivović M et al. Gaining weight and components of metabolic syndrome in the period of menopause. [in Serbian] Srp Arh Celok Lek 2008; 136: 505-513
• 9 Kirchengast S, Gruber D, Sator M et al. Postmenopausal weight status, body composition and body fat distribution in relation to parameters of menstrual and reproductive history. Maturitas 1999; 33: 117-126
• 10 Rurik I, Sandholzer H, Kalabay L. Does the dinamicity of weight gain predict the elements of metabolic syndrome?. Med Sci Monit 2009; 15: CR40-CR44
• 11 Donini LM, Savina C, Gennaro E et al. A systematic review of the literature concerning the relationship between obesity and mortality in the elderly. J Nutr Health Aging 2012; 16: 89-98
• 12 Lin Y-C, Chen J-D, Chen P-C. Excessive 5-year weight gain predicts metabolic syndrome development in healthy middle-aged adults. World J Diabetes 2011; 2: 8-15
• 13 Davis SR, Castelo-Branco C, Chedraui P et al. Writing group of the international menopause society for world menopause day 2012. Understanding weight gain at menopause. Climacteric 2012; 15: 419-429
• 14 Sternfeld B, Wang H, Quesenberry Jr CP et al. Physical activity and changes in weight and waist circumference in midlife women: findings from the Study of Women’s Health Across the Nation. Am J Epidemiol 2004; 160: 912-922
• 15 Kosková I, Petrásek R, Vondra K et al. Weight, body composition and fat distribution changes of Czech women in the different reproductive phases: a longitudinal study. Prague Med Rep 2007; 108: 226-242
• 16 Toth MJ, Tchernof A, Sites CK et al. Menopause-related changes in body fat distribution. Ann NY Acad Sci 2000; 904: 502-506
• 17 Abdulnour J, Doucet E, Brochu M et al. The effect of the menopausal transition on body composition and cardiometabolic risk factors: a Montreal-Ottawa New Emerging Team group study. Menopause 2012; 19: 760-767
• 18 Noroozi M, Rastegari Z, Paknahad Z. Type of body fat distribution in postmenopausal women and its related factors. Iran J Nurs Midwifery Res 2010; Winter15: 27-31
• 19 Simkin-Silverman LR, Wing RR, Boraz MA et al. Lifestyle intervention can prevent weight gain during menopause: results from a 5-year randomized clinical trial. Ann Behav Med 2003; 26: 212-220
• 20 Hillier TA, Fagot-Campagna A, Eschwège E et al. D.E.S.I.R. Study group: Weight change and changes in the metabolic syndrome as the French population moves towards overweight: the D.E.S.I.R. cohort. Int J Epidemiol 2006; 35: 190-196
• 21 Kirchengast S, Gruber D, Sator M et al. Hysterectomy is associated with postmenopausal body composition characteristics. J Biosoc Sci 2000; 32: 37-46
• 22 Gravena AA, Brischiliari SC, Lopes TC et al. Excess weight and abdominal obesity in postmenopausal Brazilian women: a population-based study. BMC Womens Health 2013; 13: 46
• 23 Kékes E, Kiss I. Measurement of blood pressure variability and the clinical value. [in Hungarian] Orv Hetil 2014; 155: 1661-1672
• 24 Rurik I, Ruzsinkó K, Jancsó Z et al. Primary care nutritional counseling for diabetic patients. Ann Nutr Metab 2010; 57: 18-22
• 25 Soós SA, Eöry A, Eöry A et al. Comlementary and alternative medicine from the primary physician’s viewpoint. [in Hungarian] Orv Hetil 2015; 156: 1133-1139
• 26 Szabó KJ, Ádány R, Balla J et al. Advances in the prevention, diagnoses and therapy of vascular diseases. [in Hungarian] Orv Hetil 2012; 153: 483-498