Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems

Published as part of the Cluster Recent Advances in Protein and Peptide Synthesis

Abstract

A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is simple, efficient, has minimal cellular toxicity, and might be useful in a wide range of biological research.

Key words

lipids - cell-penetrating peptides - conjugates - cell delivery - drug delivery - medicinal chemistry

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