Abstract
This account describes our studies on the total synthesis of several natural terpenoids
based on our modified biosynthetic hypothesis. Compared to the originally proposed
biosynthetic hypothesis, the modified ones proved to be more practicable for the formation
of hispidanin A, a dimeric diterpenoid, and sarcandrolide J and shizukaol D, two dimeric
sesquiterpenoids, from a viewpoint of chemical reactivity. Moreover, a cascade reaction
involving intermolecular and intramolecular cycloaddition was facilitated to expeditiously
accumulate molecular complexity in the total synthesis of bolivianine, a sesterterpenoid,
on the basis of a modified biohypothesis.
1 Introduction
2 Total Synthesis of Hispidanin A
3 Total Syntheses of Bolivianine and Isobolivianine
4 Total Syntheses of Sarcandrolide J and Shizukaol D
5 Conclusion
Key words terpenoids - total synthesis - biohypothesis - cascade - cycloaddition - cyclization
