Antioxidant Effects of Lutein in Neonatal Period

Monica Tei; Giuseppe De Bernardo; Francesco Bazzini; Antonino Santacroce; Elisa Belvisi; Marina Riccitelli; Carlotta Bracciali; Giuseppe Buonocore; Serafina Perrone; on behalf of the “Gruppo di Studio di Biochimica Clinica Neonatale della Società Italiana di Neonatologia”

doi:10.1055/s-0036-1593812

Journal of Pediatric Biochemistry, Inhaltsverzeichnis

Journal of Pediatric Biochemistry 2016; 06(02): 110-113
DOI: 10.1055/s-0036-1593812

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Antioxidant Effects of Lutein in Neonatal Period

Monica Tei

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Giuseppe De Bernardo

²Department of Emergency, UOC TIN-Neonatology, AORN Santobono-Pausilipon, Naples, Italy

,

Francesco Bazzini

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Antonino Santacroce

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Elisa Belvisi

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Marina Riccitelli

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Carlotta Bracciali

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Giuseppe Buonocore

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

Serafina Perrone

¹Department of Molecular and Developmental Medicine, General Hospital “Santa Maria alle Scotte,” University of Siena, Siena, Italy

,

on behalf of the “Gruppo di Studio di Biochimica Clinica Neonatale della Società Italiana di Neonatologia”

› Institutsangaben

Abstract

During fetal life, a right balance between oxidants and antioxidants is required for survival and growth of the fetus. At birth, an overproduction of free radicals (FRs) together with poor antioxidant defenses may be detrimental for developing organs and tissues. Protecting the newborn infant against perinatal oxidative stress (OS) is a health care priority, and therefore the search for new, safe, and efficacious antioxidants has been a major quest during the last decade. Due to its antioxidant and anti-inflammatory properties, lutein, a compound belonging to the xanthophyll family of carotenoids, is one of the most promising molecules with clinical application during neonatal age. Lutein is not synthesized by humans, hence the intake primarily depends on diet. In the neonatal period, fresh human milk is the main source of lutein, though lutein-enriched infant formulas are now available. Oral supplementation represents an alternative source of lutein, and it has been demonstrated to decrease plasma biomarkers of OS and increase antioxidant capacity in the first days of life.

Keywords

oxidative stress - free radicals - reactive oxygen species - lutein

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Referenzen

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