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Semin Reprod Med 2017; 35(04): 318-325
DOI: 10.1055/s-0037-1604095
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Investigational Medical Therapies for Endometriosis: Current Data and Future Trends

Shahryar K. Kavoussi
1   Austin Fertility and Reproductive Medicine/Westlake IVF, Austin, Texas
,
Ran Zhang
2   Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, Minnesota
,
Dan I. Lebovic
2   Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, Minnesota
3   Center for Reproductive Medicine, Minneapolis, Minnesota
› Author Affiliations
Further Information

Publication History

Publication Date:
16 October 2017 (online)

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Abstract

Current mainstays of medical therapy for endometriosis preclude fertility or may have unwanted side effects. Therefore, research has been underway to find alternatives to current options which may be applied to future medical treatment. The focus of this review is that of investigational hormonal and nonhormonal medical therapies based on in vitro and in vivo animal models of endometriosis as well as in human endometrial and endometriotic cells in vitro. Assessment of the safety and efficacy of such novel medical treatments have been, and continue to be, necessary prior to clinical trials.

Keywords

endometriosis - GnRH antagonist - aromatase inhibitor - TNFα inhibitor - VEGF
 

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