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Journal of Pediatric Neurology 2019; 17(01): 038-040
DOI: 10.1055/s-0037-1608948
Case Report
Georg Thieme Verlag KG Stuttgart · New York

An Infant with Neonatal Abstinence Syndrome in the Setting of Hydranencephaly

K. S. Deerwester
1   Tufts University School of Medicine, Boston, Massachusetts, United States
,
O. Avidan
2   Department of Pediatric Neurology, Maine Medical Center, Portland, Maine, United States
,
A. K. Craig
1   Tufts University School of Medicine, Boston, Massachusetts, United States
2   Department of Pediatric Neurology, Maine Medical Center, Portland, Maine, United States
› Author Affiliations
Further Information

Publication History

29 March 2017

26 October 2017

Publication Date:
08 December 2017 (online)

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Abstract

An infant of 37 weeks' gestation was born with signs and symptoms of neonatal abstinence syndrome (NAS). Upon further investigation, he was found to have congenital hydranencephaly, a condition in which the forebrain is absent. In this case report, we explore the mechanisms of NAS and hydranencephaly, and why an infant without a forebrain can still experience NAS symptoms.

Keywords

brain - neonatal abstinence syndrome - hydranencephaly
 

  • References

  • 1 Kocherlakota P. Neonatal abstinence syndrome. Pediatrics 2014; 134 (02) e547-e561
    CrossrefPubMedGoogle Scholar
  • 2 Jansson LM, Velez M. Neonatal abstinence syndrome. Curr Opin Pediatr 2012; 24 (02) 252-258
    CrossrefPubMedGoogle Scholar
  • 3 Jones HE, Kaltenbach K, Heil SH. , et al. Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med 2010; 363 (24) 2320-2331
    CrossrefPubMedGoogle Scholar
  • 4 Ko JY, Patrick SW, Tong VT, Patel R, Lind JN, Barfield WD. Incidence of neonatal abstinence syndrome - 28 states, 1999-2013. Morb Mortal Wkly Rep 2016; 65 (31) 799-802
    PubMedGoogle Scholar
  • 5 Finnegan LP, Connaughton Jr JF, Kron RE, Emich JP. Neonatal abstinence syndrome: assessment and management. Addict Dis 1975; 2 (1-2): 141-158
    PubMedGoogle Scholar
  • 6 Aicardi J, Bax M, Gillberg C, Ogier H. Diseases of the Nervous System in Childhood, 2nd ed. London, UK: Mac Keith Press; 2009
    Google Scholar
  • 7 Volpe JJ. Neurology of the Newborn, 5th ed. Philadelphia, PA: Elsevier Health Sciences; 2008
    Google Scholar
  • 8 Pavone P, Praticò AD, Vitaliti G. , et al. Hydranencephaly: cerebral spinal fluid instead of cerebral mantles. Ital J Pediatr 2014; 40: 79
    CrossrefPubMedGoogle Scholar
  • 9 Cecchetto G, Milanese L, Giordano R, Viero A, Suma V, Manara R. Looking at the missing brain: hydranencephaly case series and literature review. Pediatr Neurol 2013; 48 (02) 152-158
    CrossrefPubMedGoogle Scholar
  • 10 Menshawi K, Mohr JP, Gutierrez J. A functional perspective on the embryology and anatomy of the cerebral blood supply. J Stroke 2015; 17 (02) 144-158
    CrossrefPubMedGoogle Scholar
  • 11 Abercrombie ED, Jacobs BL. Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli. J Neurosci 1987; 7 (09) 2837-2843
    CrossrefPubMedGoogle Scholar
  • 12 Xi ZX, Stein EA. Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in rat. Psychopharmacology (Berl) 2002; 164 (02) 144-150
    CrossrefPubMedGoogle Scholar
  • 13 Padget DH. The circle of Willis: its embryology and anatomy. In: Dandy WE. , ed. Intracranial Arterial Aneurysms. Ithaca, NY: Comstock Publishing Company, Inc; 1944: 67-90
    Google Scholar