Key words
[2+2+2] cyclotrimerization - Diels–Alder - sultine - amino acids and peptides - spirocycles
- Wilkinson’s catalyst - Vollhardt’s catalyst - alkyne surrogates
1
Introduction
[2+2+2] Cycloaddition is a useful tool to assemble densely functionalized aromatics
in one step starting with alkynes. Moreover, this method is also applicable to annulated
benzenes by precise selection of the starting materials. The most common product of
the acetylene cyclotrimerization is benzene. Regioisomers 2a, 2b are generated when substituted alkyne 1 is used. If two different alkynes (diyne 3, monoyne 1) were tethered, annulated benzene derivatives 4a–c would be generated, whilst, if all three alkynes were connected such as 5, a tricyclic ring 6 would be formed (Scheme [1]). The driving force for the [2+2+2] cyclotrimerization reactions is the gain of
aromaticity, and the reaction is exothermic. This intramolecular approach is effective
for the synthesis of sterically demanding molecules such as helicenes.[1a]
Scheme 1
In 1866, Bertholet first reported the thermal [2+2+2] cyclotrimerization of acetylene
to benzene.[1b] The reaction is exothermic (experimental data ΔH0 = –143 kcal/mol) and suffered from the formation of a large amount of byproducts.
Despite a loss in entropy, the reaction occurs at high temperature to overcome the
large energy barrier (activation barrier at least 36 kcal/mol) of the reaction. In
1948, Reppe reported the first transition-metal-mediated [2+2+2] cyclotrimerization,
which occurrs at low temperature with fewer byproducts.[2] Since then, seventeen transition-metal catalysts based on Ni, Co, Pd, Cr, Rh, Ru,
Fe, Zr, Nb, Ir, Ta, Ti, Re, etc. have been used for the cyclotrimerization reaction
of alkynes and some of them are included in the recent reviews.[3] These transition-metal catalysts are not used to the same extent. Transition-metal
catalysts of group 9 such as Co, Rh, and Ir are mostly used in this reaction. Zirconium
only allows cyclotrimerization in the presence of another metal catalyst such as nickel.
Recently, besides the development of transition-metal catalyzed [2+2+2] cyclotrimerization
reactions, several transition-metal-free [2+2+2] cyclotrimerizations have also been
reported.[3c]
Transition-metal complexes used in [2+2+2] cyclotrimerization have emerged as indispensible
tools in synthetic organic chemistry because they can tolerate a variety of functional
groups, and this process allows incorporation of diverse substituents at a late stage
of the synthetic sequence. Interestingly, the [2+2+2] cyclotrimerization reaction
allows multiple bond formation exhibiting a high degree of selectivity in some cases.
It is an efficient protocol for assembling aromatic compounds, which can act as functional
materials. This operation is an atom-economic process leading to the formation of
unsaturated six-membered, highly substituted carbo- and heterocycles such as benzenes,
pyridines, pyridones, and 1,3-cyclohexadienes etc., in a single operation involving
catalytic amounts of organometallic complexes. Owing to the several advantages of
a [2+2+2] cycloaddition sequence, this strategy has been expanded into several areas
and found diverse applications in organic synthesis.
Traditional methods to generate functionalized aromatic rings rely on stepwise electrophilic
or nucleophilic aromatic substitution reactions. These approaches have several limitations
with regard to regiochemical issues and functional-group tolerance. The [2+2+2] cycloaddition
strategy seems to be a better option to design substituted benzenes because of its
convergent nature. In addition, functionalization of the aromatic ring by this method
can be aceived in a predetermined manner and this approach provides better regiocontrol
while incorporating various substituents in the benzenoid systems.
The exact mechanism for [2+2+2] cyclotrimerization depends on the nature of the metal
and alkyne partners. A general mechanism is shown in Figure [1]. When two alkynes coordinate to a metal center, oxidative cyclization occurs forming
metallacyclopentadiene intermediate B or metallacyclopentatriene intermediate C.[4] Coordination of the third alkyne generates a new complex, which could be transformed
either into metallacycloheptane complex D or a bicyclic complex E by an intramolecular Diels–Alder (DA)-type reaction or complex F through a [2+2] cycloaddition reaction. Finally, a reductive elimination process
affords the aromatized product, by completing the catalytic cycle.
Figure 1 A general mechanism to benzene derivatives by [2+2+2] cyclotrimerization
To test the scope and limitations of the [2+2+2] cycloaddition approach we have prepared
new building blocks, and utilized them during the past two decades in a diversity-oriented
synthesis. This approach has now widespread use in pharmaceutical industry. In this
review, we would like to demonstrate how the “building block approach”[5f] has been used to prepare several complex targets using the [2+2+2] cycloaddition
reaction as a key step. Some relevant approaches described in the literature are also
covered.
Unusual Amino Acids and Peptides
2
Unusual Amino Acids and Peptides
Indane-based α-amino acid (AAA) is a constrained analogue of phenylalanine (Phe) and
it is used extensively in the design and synthesis of a variety of bioactive peptides.
Utilization of unusual AAAs in physical and life sciences continues to grow at an
impressive rate. They are useful as building blocks for peptides, proteins, and natural
products and used extensively in pharmaceutical, agrochemical, and food industry.
The design and synthesis of peptides[5a–c] with predetermined structure is a challenging task in the present day peptide chemistry.
In this regard, conformationally restricted Phe analogues have proven to be useful
tools as they can control the secondary structure of a peptide.[5d]
[e] Moreover, incorporation of unusual AAAs into peptides may provide unique analogues
which are biologically more active and resistant to enzymatic degradation. To synthesize
diverse unusual AAA derivatives, we have adopted the “building block approach” involving
a [2+2+2] cycloaddition as a key step.
Scheme 2
This methodology involves the preparation of diyne building block 7 containing an AAA moiety which on [2+2+2] cycloaddition reaction in the presence
of Wilkinson’s catalyst or Vollhardt’s catalyst CpCo(CO)2 with various monoynes 8a–h delivers indane-based AAA derivatives such as 9 (Scheme [2]).[6] This methodology is strategically different from the other routes because the benzene
ring is generated during the cycloaddition sequence, while the other methods involve
manipulation of preformed benzene derivatives. Since the cycloaddition reaction can
generate complex targets by judicious selection of the reacting partners, we obtained
a variety of unusual AAA derivatives. Silylated benzene derivatives underwent electrophilic
substitution reactions ipso to the silyl group, and therefore the modification of the bis-silyl indane derivative
9b was also explored (Scheme [3]).
Since o-xylylene intermediate 12 can be trapped with a suitable dienophile to produce new AAA derivatives 11
[7a] the attention was focused on the generation of the sultine derivative 13 (Scheme [4]).
Scheme 3
Scheme 4
Scheme 5
Figure 2 List of indane derivatives prepared
Towards the synthesis of 11, the required indane derivative 16 was synthesized through a [2+2+2] cycloaddition of 2-butyne-1,4-diol (8c) and the diyne derivative 7a, obtained from ethyl isocyanoacetate 14. The dihydroxy indane derivative 16 was then converted into the corresponding dibromide 17 with use of PBr3. Next, a reaction of dibromo compound 17 was performed with sodium hydroxymethanesulfinate (rongalite)[7b] in the presence of tetrabutylammonium bromide (TBAB) in DMF at 0 °C, and the two
isomeric sultine-based AAA derivatives 18 were obtained in 72% combined yield (1:1) (Scheme [5]). Having the sultines 18 in hand, we explored their DA chemistry with various dienophiles to produce DA adducts.
Subsequent oxidation of the DA adducts with DDQ gave benzoannulated derivatives (11a,b). The DA reaction of 18 with other dienophiles such as 1,4-benzoquinone, 1,4-naphthaquinone, and 1,4-anthraquinone
delivered the products 11c–e. In view of various applications of fullerene-based AAA derivatives in bioorganic
chemistry, we turned our attention to incorporate the AAA moiety in the fullerene
system and successfully obtained compound 11f in 49% yield (Figure [2]). The hydrophobic character of the fullerene moiety and its ability to act as an
electron sink may make the fullerene-based AAA derivative an attractive building block
for biological applications.
Dixneuf and co-workers have developed an impressive approach to CF3-substituted benzoproline and tetrahydroisoquinoline-3-carboxylic acid derivatives
20 and 21, which is based on ruthenium-catalyzed cyclotrimerization of 1,6- and 1,7-azadiynes
19 and alkynes 8 with Cp*RuCl(cod) and the Grubbs catalyst (Scheme [6]).[8]
Scheme 6
Along similar lines, Roglans and co-workers adopted this methodology to synthesize
nonproteinogenic Phe derivatives using enantiopure and racemic propargylglycine 22 with different diynes 3 (Scheme [7]).[9] When they used Wilkinson’s catalyst or a cationic rhodium [Rh(cod)2]BF4/BINAP catalyst the required product was not formed; only homocoupling product was
observed. However, Wilkinson’s catalyst in ethanol heated to reflux gave the desired
cycloaddition product in good yields. The reaction worked well with symmetric as well
as unsymmetric 1,6-diynes; however, the regioselectivity was poor in the case of unsymmetric
diynes. Very recently, our group has shown the synthesis of benzyl halo derivatives
of aminoindane carboxylic acid (Aic) derivatives directly through a [2+2+2] cyclotrimerization
using propargyl halides as co-partners with Mo(CO)6 under microwave irradiation (MWI).[10]
Scheme 7
In 2016, Shibata et al. reported the enantioselective synthesis of Aic derivatives
through a Rh-catalyzed intramolecular [2+2+2] cycloaddition reaction. When the intermolecular
[2+2+2] cycloaddition was carried out in the presence of a Rh catalyst using (S)-BINAP as a chiral ligand, the enantioselectivity was very poor. Hence, they realized
that the enantioselectivity could be improved by intramolecular [2+2+2] cycloaddition.
Starting with triynes 25, the tethered Aic derivatives 26 were generated. Subsequently, removal of the tether gave chiral Aic derivatives 27 (Scheme [8]).[11]
Scheme 8
Similarly, they developed the synthesis of cyclic peptides. In this regard, they prepared
the triynes from 1,6-diyne and alkyne connected by a di- or tri-, or tetrapeptide
tether. Later, intramolecular [2+2+2] cycloaddition of the peptide-tethered triynes
28 in the presence of Rh(COD)2OTf/(S)-tolBINAP complex gave cyclic peptides 29 in moderate chemical yields and good diastereoselectivity. When they used bulky ligand
(S)-xylBINAP a higher diastereoselectivity was achieved. However, (R)-tolBINAP also gave the same stereoisomer suggesting that the stereoselectivity was
controlled by the chiral peptide tether, but not by chiral Rh catalysts. Moreover,
achiral ligand BIPHEP provided similar results (Scheme [9]).[12]
Scheme 9
1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (Tic),[13a]
[b] a constrained analogue of Phe, is an important structural component present in several
biologically active natural products. Incorporation of Tic in opioid receptors enhances
their affinity and selectivity. Tic can be prepared by traditional methods such as
Bischler–Napieralski or Picter–Spengler reaction, etc. These methods can accommodate
limited functionalities in the aryl ring. Tic prepared by a [2+2+2] cycloaddition
process provides an opportunity to incorporate various substituents in Tic derivatives
in a predetermined manner.[13c] In this regard, the diyne 34 was prepared from the benzophenone Schiff’s base derived from glycine ester by a
four-step sequence (Scheme [10]). Treatment of the diyne 34 with various monoynes 8 using Wilkinson’s or Vollhardt’s catalyst gave a variety of Tic-based AAA derivatives
in good to moderate yields. It is worth mentioning that similarly, Tic derivatives
were also prepared by using enyne metathesis and DA reaction as the key steps.[13c]
Scheme 10
Recently, Zotova et al. demonstrated the trifluoromethyl-substituted phosphonate analogues
of Tic derivatives 38 based on N-propargylation of α-alkynyl-α-CF3-α-aminophosphonates 36 to form 1,7-azadiynes 37, followed by co-cyclotrimerization with terminal alkynes 1b–d using two types of ruthenium catalysts: Cp*RuCl(cod) and preferably the alkene-metathesis[14a]
[b] Grubbs second-generation catalyst (Scheme [11]).[14c]
Scheme 11
Kotha and Banerjee have developed a short and efficient synthetic route to Tic-quinone
hybrids 42a–d using a [2+2+2] and a [4+2] cycloaddition reaction as the key steps. The o-xylylene intermediate required for the DA reaction was prepared through the sultine
methodology by using rongalite (Scheme [12], Figure [3]).[15] The required diol building block 35a used for the preparation of sultine 40, was prepared by following a [2+2+2] procedure starting with alkyne building block
34, which in turn can be obtained from benzophenone imine 30. The starting material 32 is commercially available in enantiomerically pure form. The method can be easily
extended to the preparation of optically active Tic derivatives 42a–d (Figure [3]). The compounds prepared here may find further applications in drug design and peptide
modifications. They can be used as building blocks in pharmaceutically active molecules,
ligands for catalysis, liquid crystals, organic semiconductor, polymers, and sensors.
Scheme 12
Figure 3 List of Tic derivatives prepared with use of rongalite
A general goal of peptide research is to design modified peptides that may enhance
the pharmacological profile of the native peptide. In this connection, Kotha and co-workers
were interested in peptide modifications by adapting the “building block approach”
to generate a large number of compounds starting with a common precursor.[16] For the first time, a new strategy for the modification of Phe peptides by a [2+2+2]
cycloaddition reaction was developed and these peptides might be useful in developing
combinatorial libraries of peptidomimetics. In this regard, the dipeptide precursor 44 was easily synthesized by a standard peptide synthesis protocol starting with the
dipropargyl glycine 43 as the key amino acid building block. The dipropargyl glycine was prepared from ethyl
isocyanoacetate 14 in a four-step sequence (Scheme [13]). The dipeptide precursor 44 was treated with five-fold excess of but-2-yn-1,4-diol (8c). Here, the monoyne was chosen to avoid the formation of diastereomers and the representative
constrained Phe peptides 45 were obtained in good yield.[16]
Scheme 13
Later, the dihydroxy derivative 45 was treated with PBr3 in benzene to obtain the corresponding dibromide. However, several attempts could
not deliver the desired product. Either, decomposed product or starting material was
recovered under these conditions. However, recently we have developed a new protocol
using a [2+2+2] cyclotrimerization with propargyl halides to generate halide derivatives
directly in a one-step procedure without the formation of the hydroxy derivative.
By using this protocol, dipropargyl peptide was treated with propargyl halides in
the presence of Mo(CO)6 under MWI conditions to generate the trimerized halo derivatives.[10]
Heteroanalogues of Indane
3
Heteroanalogues of Indane
Kotha and co-workers synthesized 1,3-dihydroisobenzofuran 46 derivatives starting with propargyl halides (1a, 8i, 8j, 8k) and dipropargylether 3a through a [2+2+2] cycloaddition reaction (Scheme [14]). In this regard a minor amount of dimer 47 is observed. Furthermore, the dibromo derivative of 1,3-dihydroisobenzofuran 46b was used to prepare benzosultine-sulfone 51 by using rongalite (Scheme [15]).[17a] Benzosultine-sulfone 51 is a hybrid molecule which can participate in the DA reaction in a stepwise manner
by opening the sultine or the sulfone fragment at different temperatures, and the
respective o-xylylene intermediate can be trapped with different dienophiles. This approach delivers
densely functionalized polycyclic compounds.
Scheme 14
Scheme 15
Later on, Kotha and Sreevani have shown the synthesis of dipropargyl sulfone 3b from rongalite and propargyl bromide in a single step. The building block 3b was also converted into benzosultine-sulfone 51 through [2+2+2] cyclotrimerization reaction by using 1,4-dibromo-2-butyne (8i) and Mo(CO)6 as a catalyst in a short two-step synthetic sequence (Scheme [16]).[17b]
Furthermore, the methodology has been extended to prepare isoindoline and isoindolinone
halide derivatives (Schemes 17 and 18).[17c]
Scheme 16
Scheme 17
Scheme 18
Witulski and co-workers reported a [2+2+2] cyclotrimerization[18a] for the synthesis of 4,6- or 4,5-substituted indoline derivatives 55 and 56 using Grubbs and Wilkinson’s catalysts, respectively (Scheme [19]).
Scheme 19
Diphenylalkane Derivatives
4
Diphenylalkane Derivatives
The diphenylalkane moiety is present in a variety of natural products and in biologically
important molecules. For example, 1,3-diphenylpropane (viscoline) isolated from hemiparasitic
herb is used in Chinese medicine for a number of diseases such as haemorrhage, gout,
heart diseases, epilepsy etc. 1,2-Diphenylethane derivatives possess cytotoxic activity
towards genital fibroblasts and also show antiestrogenic activity. In 1980, Ibuki
et al. demonstrated a general method for the preparation of diphenylalkane derivatives
of varied chain lengths using a benzenoid precursor.[19a] Recently, Kotha and Khedkar have developed a new approach to diphenylalkane derivatives
using a [2+2+2] cycloaddition, cross-enyne metathesis (CEM), and DA reactions as the
key steps.[19b] In this connection, various α,ω-diynes such as 1,5-hexadiyne (3e, n = 0), 1,6-heptadiyne (3f, n = 1), 1,7-octadiyne (3g, n = 2), and 1,8-nonadiyne (3h, n = 3) were subjected to a [2+2+2] cyclotrimerization reaction with dimethyl acetylenedicarboxylate
(DMAD, 8g) using Wilkinson’s catalyst, and the polysubstituted benzene derivatives 57 were produced in 41–48% yield. Alkynes 57 were subjected to CEM with ethylene in the presence of a G II catalyst, by using
toluene as the solvent, and the diene derivatives 58 were obtained in excellent yields. Microwave irradiation of the reaction mixture
with DDQ delivered the corresponding aromatized diphenylalkane derivatives 60 in good yields (Scheme [20]). The methodology is suitable for a diversity-oriented approach to synthesize densely
functionalized diphenylalkane derivatives. The two different polysubstituted aromatic
rings are built at the two ends of the α,ω-diyne scaffold in a stepwise manner.
Scheme 20
Multi-Armed Aryl Benzene Derivatives
5
Multi-Armed Aryl Benzene Derivatives
Kotha and co-workers have prepared bis- and trisaryl benzene derivatives through a
[2+2+2] cyclotrimerization reaction using the Grubbs first generation catalyst (G
I).[20a] It was found that the G I catalyst is more suitable for cyclotrimerization than
the Grubbs second generation (G II) catalyst. The G I catalyst shows higher initiation
and low propagation rates, whereas the G II catalyst has low initiation and high propagation
rates. To this end, commercially available acetophenone derivatives 61 were converted into acetylenes 63 through the Vilsmeier reaction. Acetylenes 63 were subjected to a [2+2+2] cyclotrimerization with DMAD in the presence of the G
I catalyst (5 mol%) in toluene heated to reflux to deliver the terphenyl systems 64 in 62–75% yield (Scheme [21]). The [2+2+2] cycloaddition reaction of acetylenes 63 was also studied with other acetylenic partners, such as 1,4-dibromobut-2-yne, 1,4-diacetylbut-2-yne,
and 1,4-dihydroxybut-2-yne but the desired [2+2+2] cyclotrimerized product was not
observed. Therefore, acetylene derivatives with electron-withdrawing groups such as
DMAD are required for the successful implementation of the [2+2+2] cyclotrimerization
reaction with phenylacetylene derivatives. As an extension to the above methodology,
products 64 were subjected to a Suzuki–Miyaura (SM) cross-coupling reaction[20b]
[c]
[d] with different boronic acids such as 4-acetyl-, 4-formyl-, and 4-methoxyphenylboronic
acid using Pd(PPh3)4 catalyst (5–9 mol%) in a tetrahydrofuran/toluene/water (1:1:1) mixture in the presence
of sodium carbonate as a base. The SM cross-coupling products (65a–f) were hydrolyzed during the course of the reaction.
Scheme 21
To synthesize 1,3,5-triaryloxymethylbenzene derivatives through a [2+2+2] methodology
using Grubbs catalyst, (prop-2-ynyloxy)benzenes 67 were prepared by reaction of phenol derivatives 66 with propargyl bromide (1a) in acetone heated to reflux in the presence of K2CO3. The propargylated compounds 67 were then treated with G I catalyst (7.5 mol%) in toluene at 80 °C. A mixture of
symmetric 1,3,5- and unsymmetric 1,2,4-triaryl benzene derivatives 68 and 69 were obtained as white solids along with depropargylated product 66. It was observed that the G I catalyst was more effective for the [2+2+2] cyclotrimerization
than the G II catalyst. With catalysts G III and G IV the depropargylated product
66 was obtained as a major product (Scheme [22]).[21]
Scheme 22
Along similar lines, Tanaka and co-workers found that a cationic rhodium(I)–H8-BINAP complex catalyzes the complete intermolecular homo- and a cross- [2+2+2] cycloaddition
of aryl ethynyl ethers 70 at room temperature, with electron-deficient internal monoalkynes, leading to tri-
and diaryloxybenzenes, respectively (Scheme [23]).[22]
Scheme 23
Feng et al. reported the synthesis of two different tetrasubstituted benzenes 74 and 75 (Scheme [24]) from the same starting material 8h simply by catalysis with G II in the presence of an additive CuI (73a) or AgOTf (73b).[18b]
Scheme 24
Chen and co-workers reported the intermolecular cyclotrimerization of unsymmetric
diarylalkynes 76 in the presence of Co2(CO)8 to produce the corresponding 1,2,4-regioisomers 77 or 1,3,5-regioisomers 78 with excellent yields and high regioselectivity (Scheme [25]).[18c]
Scheme 25
Annulated Benzocycloalkanes
6
Annulated Benzocycloalkanes
Kotha and Khedkar reported an interesting reactivity pattern of hybrid o-quinodimethane precursor 82. This hybrid compound containing benzocyclobutane and benzosulfone moieties was prepared
by a [2+2+2] cycloaddition reaction and utilization of rongalite (Scheme [26]).[23] The DA reaction of o-quinodimethane precursor 82 can generate various annulated benzocycloalkanes. For example, the selective DA reaction
was realized at the sultine 82 or the sulfone 84 frame and not at the other end of o-quinodimethane precursor, i.e. the benzocyclobutane moiety. The DA reaction was studied
under different conditions such as conventional heating, MWI, in the presence of an
excess amount of dienophile, removal of SO2 as it is generated in the reaction by continuous bubbling of N2 gas. This hybrid system with differential reactivity pattern is likely to find interesting
applications in organic synthesis.
Scheme 26
7
Spirocycles
The spiro unit is an important structural element present in several natural products
(e.g. terpenoids and alkaloids) and non-natural products. Recently, they have found
important applications in materials science and also in medicinal chemistry. The attractive
conformational feature of the spiro center is responsible for the biological activity.
Because of the presence of an axial chirality, these compounds are useful in designing
new chiral ligands and catalysts applicable in asymmetric synthesis. Hudlicky has
once remarked that the generation of a spiro center is a highly difficult task because
it involves the generation of a quaternary center.[24a] There are many methods known in the literature for the synthesis of spirocyclic
compounds[24] but many of these methods have several limitations such as low functional group
tolerance, restriction to particular substitution patterns etc. In this regard, there
is a compelling need to develop new methods to form spirocycles. During the past few
years, Kotha and co-workers have made continuous effort to prepare diverse spirocycles[24c]
[d]
[e]
[f] using the “building block approach” and some of them are described here.
Kotha and Manivannan envisaged the spiro compound 86 as a useful precursor for the synthesis of unsymmetric benzoannulated systems.[24g] They have found that there are two possible retrosynthetic routes for the preparation
of 86; one using a [2+2+2] cycloaddition (path A, Scheme [27]) and the other using [4+2] cycloaddition (path B, Scheme [27]). These routes are strategically different and, using the above methodologies, they
have shown that [2+2+2] and [4+2] cycloaddition strategies are useful to prepare various
2,2-spirobisindane-1,3-dione derivatives. To realize the [2+2+2] strategy the key
intermediate was prepared by bispropargylation of 1,3-indanedione (89) with propargyl bromide (1a) by using a phase-transfer catalyst (Scheme [28]). With the prepared compound 87 a [2+2+2] cycloaddition sequence was performed with use of η5-cyclopentadienylcobalt complex CpCo(CO)2 as a catalyst. Here, slow addition of diyne 87 and catalyst in dry toluene to a solution of alkyne heated to reflux under inert
conditions gave the required linear spiro derivatives 86. Various monoynes underwent the cyclotrimerization reaction under these conditions.
Scheme 27
Scheme 28
Starting with same material (1,3-indanedione, 89) Kotha and co-workers have prepared several angularly as well as linearly fused spirocyclic
derivatives. To this end, a [2+2+2] cycloaddition and DA reaction were used sequentially
as the key steps.[25] The [2+2+2] cycloaddition of dipropargylated compound 87 with 2-butyne-1,4-diol in dry ethanol in the presence of Wilkinson’s catalyst gave
diol 90 in 39% yield along with a small amount (4%) of the dimer (Scheme [29]). Since Ti(O
i
Pr)4 facilitates enyne metathesis,[25c] a similar role was anticipated in a [2+2+2] cycloaddition sequence. When Ti(O
i
Pr)4 was used in catalytic amount, the yield of diol 90 increased to 46% along with a minor amount (7%) of the dimer. Diol 90 was then converted into the dibromo derivative 91 by using PBr3 in dry benzene at room temperature, and this dibromide was then converted into sultine
derivative 92 by treatment with rongalite in dimethylformamide. The diene intermediate was generated
from sultine 92 in toluene heated to reflux and was trapped with 1,4-naphthoquinone to deliver the
corresponding DA adduct. Dehydrogenation of the DA adduct with DDQ in toluene heated
to reflux produced the aromatized product 93a. Other linearly fused spirocycles 93b–d prepared by this methodology are shown in Figure [4].
Scheme 29
Figure 4 Linearly fused spiro derivatives
Although a [2+2+2] cycloaddition reaction has been applied with several substrates,
limited examples are available where propargyl halides are used as co-partners. In
all these examples propargyl diol is used as co-trimerized partner and the resulting
dihydroxy derivative obtained in a [2+2+2] cycloaddition reaction is transformed into
the corresponding bromide by using PBr3. This strategy could not be extended to sensitive substrates such as Meldrum’s acid,
peptides, ethers, and these substrates decompose during the bromination sequence.
To expand its utility in organic synthesis, we have studied the use of propargyl halides
in a [2+2+2] cycloaddition under different catalysts/conditions. Kotha and Sreevani
have demonstrated a [2+2+2] cycloaddition strategy with propargyl halides using a
Mo catalyst, Mo(CO)6, under MWI conditions.[10a] Mo complexes are not the regular catalysts for a [2+2+2] cyclotrimerization sequence.
The mechanism may involve the formation of molybdenacyclopentadiene which would react
with the alkyne partner to produce the cyclotrimerized product. In this context dipropargylated
1,3-indane dione 87 was chosen as a model substrate (Scheme [30]). Diyne 87 was then subjected to a [2+2+2] cycloaddition sequence with propargyl bromide (1a) in the presence of a catalytic amount of Mo(CO)6 in THF heated to reflux for 10 hours. The desired [2+2+2] cycloaddition product 94 was obtained (34%) along with self-dimerized product 96 (5%) and the unsaturated aldehyde 95. After considerable amount of experimentation, it was found that the reaction was
successful with acetonitrile under MWI conditions at 90 °C. The yield of the trimerized
product 94 was improved to 75%. This may be due to in situ formation of the air-sensitive catalyst
(CH3CN)3Mo(CO)3 when Mo(CO)6 was heated with acetonitrile, and this could facilitate the reaction. Additionally,
the high dielectric constant of acetonitrile facilitates the absorption of MW radiation
to enhance the rate of the reaction. The [2+2+2] cyclotrimerization was achieved with
a variety of active methylene-based diynes and different propargyl halides under similar
reaction conditions and the corresponding benzyl halide derivatives were isolated
in good yields.
Scheme 30
Later, this technology has been extended to barbituric acid, Meldrum’s acid, hydantoin
derivatives, thiazolidines, amino acids, and peptides to synthesize the corresponding
halo(methyl)benzene derivatives 102–106 and 17 in moderate to good yields (Scheme [31]).[10b]
Scheme 31 Preparation of halo(methyl)benzene derivatives containing different heterocycles
In continuation of our efforts to the synthesis of spirocycles, Kotha and Ali have
developed a new strategy[26a] involving a sequential usage of [2+2+2] and [4+2] cycloadditions. To design intricate
spirocycles, readily available carbonyl compounds (i.e. mono ketones 107) were tetrapropargylated. Later, reactions of the tetrapropargyl ketones 108 with 2-butyne-1,4-diol (8c) were performed in the presence of Wilkinson’s catalyst and a catalytic amount of
Ti(O
i
Pr)4 to deliver [2+2+2] cycloaddition products 109 (Scheme [32]). Next, the tetraol derivatives 109 were directly converted into tetra-bromides 110 so that they can be transformed into sultines 111 by using rongalite. Then, reactions of these sultines were performed with different
dienophiles in a DA fashion to generate various complex bis-armed spirocycles 112 (Figure [5]) in excellent yield. Unexpectedly, the DA reaction with 1,4-naphthaquinone and DMAD
(8g) gave the corresponding mono-DA adducts which on subsequent dehydrogenation furnished
the aromatized products.
Scheme 32
Figure 5 Bis-spirocycles prepared with use of rongalite and a DA strategy
Later on, this strategy has been extended to bis-armed spirocycles 115 and 116 containing a bicyclo[2.2.2]octane system through a [2+2+2] cyclotrimerization followed
by a DA reaction.[26b] The required tetrayne 114 was prepared by propargylation of dione 113 (Scheme [33]), which was synthesized from commercially available hydroquinone. Further, the tetrayne
114 was treated with 1,4-dihydroxy-2-butyne (8c) in the presence of Wilkinson’s catalyst to obtain tetraol 115, which on treatment with PBr3 in CH2Cl2 without isolating the intermediate tetraol afforded the desired tetrabromo derivative
116. In this context, we directly treated the tetrapropargylated compound 114 with 2-butyne-1,4-dibromide (8i) in the presence of Wilkinson’s catalyst; however, unfortunately, we did not achieve
the desired product. Later on, we treated the propargyl building block 114 with 8i and Mo(CO)6 under MWI conditions in CH3CN at 90 °C and the spiro-annulated building block 116 was obtained in 40% yield. Next, tetrabromide 116 was successfully converted into the sultine derivative 117 by using rongalite followed by the DA sequence with tetracyanoethylene, which delivered
the cyclo adduct 119 in 67% yield (Scheme [34]). Moreover, the sultine derivative 117 was rearranged to bis-sulfone derivative 118 in toluene heated to reflux in good yield.
Scheme 33
The spirooxindole moiety is a critical structural unit present in drugs, which show
antimalarial, anticancer, and antimicrobial activity. To this end, to synthesize various
spirooxindole derivatives, Kotha and Ali conceived a strategy on the basis of a [2+2+2]
cycloaddition and a DA reaction.[27] In this regard, N-methyl derivative of oxindole 120 was dipropargylated and subsequent [2+2+2] cycloaddition yielded diol 122, which on treatment with PBr3 in CH2Cl2 afforded the dibromo building block 123. Later, the dibromo derivative 123 was converted into the sultine derivative 124 (76%), and subsequent treatment with tetracyanoethylene delivered the DA adduct 125 (72%, Scheme [35]).
Scheme 34
Kotha and Ali reported several linearly annulated spirocyclic compounds starting with
inexpensive and commercially available active methylene compounds (AMCs) 126a–g (Figure [6]). These AMCs were dipropargylated; the selection of the base used during the dipropargylation
step depends on the acidity of the AMCs.[28] The dipropargylated compounds were further subjected to a [2+2+2] cycloaddition
reaction with 2-butyne-1,4-diol with the aid of Wilkinson’s catalyst and a catalytic
amount of Ti(O
i
Pr)4 to afford the diol. Next, treatment with PBr3 delivered the dibromo compounds in good yield. Further, these dibromo compounds were
treated with rongalite in DMF to deliver the sultine derivatives, which on reaction
with dienophiles in a DA fashion produced the cycloadducts. Finally, dehydrogenation
delivered several linearly fused spirocycles 127a–h (Figure [7]). Interestingly, fluorenes are a unique class of blue-emitting molecular entities
used in polymer light-emitting diodes (PLEDs). Moreover, they also found useful applications
as sensors, and their remarkable quantum efficiency has made them important in the
field of optoelectronics. Recently, much attention has been paid towards the synthesis
of ladder-type oligomers and polymers of fluorenes with a rigid spiro linkage in their
structures. Therefore, these fluorene-based spirocycles (e.g. 131) prepared by this simple methodology (Scheme [36]) may find useful application in polymer chemistry and materials science.
Kotha and co-workers also have reported spirobarbituric acid derivatives 134a–d using a similar methodology starting from barbituric acid (Scheme [37]).[29]
Figure 6 List of active methylene compounds used for the synthesis of 1,6-diynes
Scheme 35
Figure 7 Compounds prepared by [2+2+2] cycloaddition followed by DA reaction
Scheme 36
Scheme 37
Selectivity in [2+2+2] Cycloaddition of Alkynes
8
Selectivity in [2+2+2] Cycloaddition of Alkynes
One of the disadvantages of a [2+2+2] cyclotrimerization reaction is the formation
of regioisomeric products, i.e. the lack of selectivity. This problem can be addressed
by using some of the strategies mentioned here. For example, use of a temporary tether
to combine two alkynes allows overcoming the problems associated with the formation
of regioisomers in intermolecular reactions or avoids the formation of isomers in
partially intermolecular [2+2+2] cycloaddition reactions. Yamamoto and co-workers
reported a chemo- and regioselective ruthenium-catalyzed intermolecular cyclotrimerization
of three different unsymmetric alkynes by means of a temporary tethering approach
involving boron. Alkynylboronates 135, propargylic alcohol 1e, and terminal alkynes were cyclotrimerized in the presence of Cp*RuCl(cod) generating
an arylboronate intermediate 138 which could be isolated or subjected to further synthetic manipulations such as Suzuki–Miyaura
coupling with various aryl iodides or palladium(II)-catalyzed carbonylation reaction
(Scheme [38]).[30]
Scheme 38
Selectivity in intermolecular cyclization of different partners (1b, 1e, and 141) can be achieved by using disposable linkers such as temporary silyl tethers. In
this context, Malacria and co-workers utilized silicon tether 142 that allowed the transformation of intermolecular reactions into intramolecular versions
in the presence of a cobalt(I) catalyst, generating a highly chemo- and regioselective
product 143. Finally, the tethers could be selectively removed after the reaction heading to
the creation of functionalized arenes 144 (Scheme [39]).[31]
Scheme 39
Mori et al. have reported a highly regioselective Ni-catalyzed [2+2+2] cycloaddition
of two distinct alkynes using additives such as diethyl zinc and phenol. Reaction
of methyl propiolate (1g) with trimethylsilyl protected propargyl alcohol 1h afforded the cycloadducts 145 and 146 in 95:5 regioselectivity (Scheme [40]).[32]
Scheme 40
The regioselectivity problem was addressed by a reaction of alkynes together with
a suitable linker (e.g. 1,6-diynes or 1,7-diynes). The 1,2-bis(diphenylphosphino)ethane
(DPPE)-bound Ni catalyst can facilitate the reaction of 1,6 diynes 3e with 1,3-diyne 147. The diynes bearing electron-withdrawing ester groups on the termini gave excellent
yields. Furthermore, unsymmetric 1,3-diyne 149 coupled regioselectively with 1,6-diyne 3f to give arylalkyne 150 (Scheme [41]).[33]
Scheme 41
Deiters and co-workers developed solid-supported diyne substrates for controlling
the regioselectivity during a [2+2+2] cyclotrimerization sequence. A variety of diynes
were immobilized on polystyrene resin by using trityl or carboxy linkers, and a [2+2+2]
cyclotrimerization was conducted with various symmetric as well as unsymmetric alkynes
in the presence of Wilkinson’s catalyst or Cp*RuCl(cod) catalyst. Unsymmetric alkynes
in the presence of Wilkinson’s catalyst showed poor regioselectivity; however, using
Cp*RuCl(cod) catalyst, high regioselectivity was observed (meta/ortho 9:1) (Scheme [42]). This method avoids self-coupling reaction of diynes and facilitates easy separation
of cross-cycloaddition products. The compounds were obtained in good to excellent
yields and with high purities after cleavage from the solid support.[34a] Later, the same group reported solid-supported [2+2+2] cycloaddition reactions under
MWI conditions using Cp*RuCl(cod) catalyst.[34b]
Scheme 42
By an intramolecular cycloaddition strategy, one can solve selectivity issues (Scheme
[43]). Totally intramolecular [2+2+2] cyclotrimerization was observed in 15- and 25-membered
polyacetylenic azamacrocycles with Wilkinson’s catalyst. The expected cyclotrimerized
compound was obtained in 54 and 50% yield, respectively. However, 20-membered azamacrocyle
gave no product because of the lack of reactivity.[34c]
[d] This reaction is very attractive and of high synthetic potential because of its
chemo- and regioselectivity. Limited reports are available, which is due to the difficulty
in designing of the triyne substrate.
Scheme 43
Peters and Blechert were the first to report fully intramolecular cyclotrimerization
using Grubbs catalyst.[35a] The mechanistic explanation for the reaction involves a cascade of four metathesis
reactions occurring to isomerize the triynes to benzene derivatives using Grubbs catalyst.[35a] Yamamoto and co-workers demonstrated that 1,6,11-triyne 5 on cyclization in the presence of 1 mol% catalyst 156 produced the tricyclic compound 6 in 82% yield (Scheme [44]).[35b]
Scheme 44
[2+2+2] Cycloaddition Reactions under Evironmentally Friendly Conditions
9
[2+2+2] Cycloaddition Reactions under Evironmentally Friendly Conditions
Despite several advances in metal-catalyzed [2+2+2] cycloaddition processes for laboratory
uses, this process still needs additional improvements with respect to the development
of environmentally friendly and scalable procedures that are applicable on industrial
scale. In this regard, Oshima and co-workers, in 2003, reported a rhodium-catalyzed
[2+2+2] cyclotrimerization of triynes in a water-organic biphasic system.[36a] Later, Cadierno et al. have reported intermolecular cyclotrimerization of alkynes
(1b, 1c, and 1j) in aqueous medium using a commercially available ruthenium(IV) dimer (Scheme [45]).[36b]
Scheme 45
In 2010, Tsai and co-workers demonstrated a [2+2+2] cycloaddition of α,ω-diynes (3a, 3c, and 3g) catalyzed by [Rh(COD)Cl]2/cationic 2,2'-bipyridyl system 158, with terminal (1c, 1e, and 1k) and internal alkynes (8k and 8l) in water in the presence of air at 60 °C (Scheme [46]). After separation of the organic products from the reaction mixture by extraction,
the residual aqueous solution could be reused for further reactions until complete
degradation of its catalytic activity.[36c]
Scheme 46
Recently, Goswami and co-workers prepared an iron-based catalytic system FeCl2
·4H2O/dipimp/Zn to accomplish [2+2+2] cycloaddition reactions. They reported an eco-friendly
[2+2+2] partially intramolecular reaction using the same catalytic system in ethanol
to prepare N-substituted indolyl-aryl derivatives 160 in good yields (Scheme [47]). Here, the reaction was carried out in ethanol as the solvent and iron(II)chloride
tetrahydrate acts as the metal source, 2-[(2,6-diisopropylphenyl)iminomethyl]pyridine
(dipimp) as the ligand, and zinc as the reducing agent.[37]
Scheme 47
10
Alkyne Surrogates
Synthesis of fused benzene rings can also be accomplished by using alkyne surrogates
during the [2+2+2] cycloaddition reaction with diynes. This alternate method avoids
the selectivity problems. Several groups have reported the use of enol ethers or easily
enolizable ketones as alkyne equivalents that undergo dehydration after the cyclotrimerization
giving the aromatic products. Some recent examples, depicted in Scheme [48], show diynes reacting with rhodium(I)/BINAP catalyst system with enolethers[38a] 161, vinylene carbonates[38b] 163, or 2-oxazolones[38c] 167. The regioselectivity of the enol ether insertion is thought to be controlled by
coordination of the enol carbonyl moiety to the cationic Rh center in the metallacyclopentadiene
intermediate. If the enol ether component is replaced by vinylene carbonate 163, a phenol derivative 164 is obtained, whereas the reaction with ketene acetal 165 gives aromatic ether 166, and the reaction with 2-oxazolones 167 gives anilines 168. In addition, Matsuda and co-workers showed that substituted maleic anhydride functioned
as synthetic equivalent of alkynes in a rhodium(III)-catalyzed [2+2+2] cyclotrimerization
reaction with 1,6-diynes.[38d]
Scheme 48
In 2015, Ichikawa and co-workers demonstrated the synthesis of fluorobenzene derivatives
172 through a nickel-catalyzed intermolecular [2+2+2] cycloaddition reaction using 1,1-difluoroethylene
169 as an alkyne surrogate (Scheme [49]). They have also demonstrated that this reaction works with 1,6-enynes in a partially
intramolecular fashion.[38e]
For the first time in 1973, Yamazaki reported the application of a [2+2+2] cycloaddition
reaction for the synthesis of heterocycles where nitrile 173 has been used as a co-partner with two acetylenes in the presence of a cobalt catalyst
leading to the formation of pyridines 174.[39a] Later on, it was found that not only acetylenes and nitriles, but also other partners
such as cyanates, isocyanates 175, carbonyls 179, and carbon disulfide (183) etc.[39b] participate in the [2+2+2] cycloaddition reaction, thereby enabling the formation
of a variety of heterocyclic aromatic as well as nonaromatic compounds such as pyridones,
pyrans, pyranones, etc. (Scheme [50]).[39]
Scheme 49
Scheme 50
Double bonds that form parts of heterocycles are also known to participate in the
[2+2+2] cycloaddition reaction with alkynes. Although they are resonance stabilized,
cobalt-mediated heterocyclic activation allows these systems to participate readily
in cyclization reactions. Thus, π-enriched systems, such as furans,[40a] thiophenes,[40a]
[b] pyrroles,[40c] and imidazoles[40d] deliver fused dihydro heterocycles. Recently, this methodology has been extended
to indoles,[41] pyrimidines,[42a]
[b] pyridines, and pyrazinones.[42c]
Domino Reactions Involving [2+2+2] Cycloaddition
11
Domino Reactions Involving [2+2+2] Cycloaddition
A useful approach to accomplish molecular complexity in one step is the domino reaction.
This theme has drawn increasing attention in recent years. However, unfortunately
only a limited number of domino reactions are known where a [2+2+2] cycloaddition
is used in combination with other reactions. Benzolactones and lactams are found in
plants and they show pharmacological activity.[43a] Chang and co-workers demonstrated a one-pot synthesis of benzolactone 185 and lactam 186 through a cobalt-catalyzed regioselective [2+2+2] cyclotrimerization and trans-esterification
of alkynyl alcohols 1f and amines 1l with propiolates 1g (Scheme [51]).[43b] Tanaka and co-workers have prepared enantioenriched tricyclic phthalide derivatives
188 by a cationic Rh(I)/SOIPHOS complex-catalyzed asymmetric one-pot trans-esterification
and a [2+2+2] cycloaddition reaction (Scheme [52]).[44]
Scheme 51
Scheme 52
Li and Bonfield have prepared isoindoline derivatives 192 by treating amines 190 with aldehyde 191 and alkynes 1c (Scheme [53]). Three consecutive reactions take place in a single synthetic operation. First,
one molecule of amine combines with two molecules of aldehyde and two molecules of
alkyne to give the starting diyne which on cycloaddition with a third alkyne gives
the final isoindoline derivative. The first coupling reaction is catalyzed by CuBr
and the cycloaddition reaction is catalyzed by Wilkinson’s catalyst. Therefore, both
are added from the beginning.[45]
Scheme 53
Biologically Important Targets/ Total Synthesis
12
Biologically Important Targets/ Total Synthesis
Ramana and co-workers also used a [2+2+2] cycloaddition to synthesize bicyclic and
tricyclic derivatives. They reported the application of intermolecular [2+2+2] alkyne
cyclotrimerization reactions for the construction of benzannulated 8-oxabicyclo[3.2.1]octane
systems 194 (Scheme [54]) and this strategy was applied for the synthesis of (–)-bruguierol A.[46a]
Scheme 54
A similar strategy was employed to construct the central 4/5/6 tricyclic framework
of 6-(1-hydroxyethyl)-cyclonocardicin trinems 196 (Scheme [55]).[46b]
Scheme 55
The same group has also synthesized 6,7-cyclopropylallocolchicinoids 198 using cobalt-catalyzed [2+2+2] cyclotrimerization to construct the ABC ring system
(Scheme [56]).[46c] Along similar lines, they have also shown the total synthesis of (±)-allocolchicine
and its analogues.[46d] Kotha and Sreevani have demonstrated a formal total synthesis of an isoindoline
derivative of Hsp90 inhibitor AT13387 (Scheme [57]).[17c]
Scheme 56
Scheme 57
13
Conclusions
In this account, we have demonstrated that a [2+2+2] cycloaddition sequence is a useful
tool to assemble various carbo- and heterocycles, spirocycles and polycycles including
unusual amino acids and peptides. In this regard, we have used Wilkinson’s catalyst,
Vollhardt’s catalyst, and Grubbs catalyst. More interestingly, we found that propargyl
halides can be useful co-partners when Mo(CO)6 is applied as a catalyst. For the first time, we have used Ti(O
i
Pr)4 to improve the [2+2+2] cycloaddition with Wilkinson’s catalyst. We also included
the work of others to keep a balanced view of the theme. The strategies and the compounds
developed here are likely to find useful applications in materials science and in
the design of pharmaceutically important drugs. Since a [2+2+2] cycloaddition is considered
as an atom-economic process, our results may be of interest to several chemists working
in the area of green chemistry. Although this strategy has witnessed several advances,
its application on industrial scale is yet to be seen.
