Synlett 2019; 30(18): 2041-2050
DOI: 10.1055/s-0037-1611905
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© Georg Thieme Verlag Stuttgart · New York

Recent Advances in the Synthesis of Thiadiazoles

Yan Xiao
,
Song Sun
,
Jin-Tao Yu
,
Jiang Cheng
We thank the National Natural Science Foundation of China (No. 21572025, 21602019, 21672028), “Innovation & Entrepreneurship Talents” Introduction Plan of Jiangsu Province, Natural Science Foundation of Jiangsu Province (BK20171193), Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology (BM2012110), and the Advanced Catalysis and Green Manufacturing Collaborative Innovation Center for financial support.
Further Information

Publication History

Received: 03 July 2019

Accepted after revision: 16 July 2019

Publication Date:
05 September 2019 (online)


Abstract

Thiadiazole moieties are present in many natural products and pharmaceutical compounds that possess a broad spectrum of biological activities, serving as antidepressant, anxiolytic, antimicrobial, antitubercular, antiinflammatory, antidiabetic, anticancer, antihypertensive, or antifungal drugs. Many excellent methods have been reported for accessing such frameworks. In this review, we summarize advances made within the past ten years in the synthesis of various types of thiadiazole.

1 Introduction

2 Synthesis of Thiadiazoles

2.1 Synthesis of 1,2,3-Thiadiazoles

2.1.1 Synthesis of 1,2,3-Thiadiazoles from Diazo/Azide Compounds

2.1.2 Synthesis of 1,2,3-Thiadiazoles from Sulfonyl Hydrazines or N-Tosylhydrazones

2.2 Synthesis of 1,2,4-Thiadiazoles

2.2.1 Synthesis of 1,2,4-Thiadiazoles from Thioamides or their Derivatives

2.2.2 Synthesis of 1,2,4-Thiadiazoles from Amidines or 2-Aminopyridines

2.3 Synthesis of 1,3,4-Thiadiazoles

2.4 Synthesis of 1,2,5-Thiadiazoles

3 Conclusion

 
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