D-Dimer as a Risk Factor for Deep Vein Thrombosis: The Leiden Thrombophilia Study

Astrid C. M. Andreescu; Mary Cushman; Frits R. Rosendaal

doi:10.1055/s-0037-1612942

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 87(01): 47-51
DOI: 10.1055/s-0037-1612942

Review Article

Schattauer GmbH

D-Dimer as a Risk Factor for Deep Vein Thrombosis: The Leiden Thrombophilia Study

Astrid C. M. Andreescu

¹ Department of Medicine, Division of Hematology, Oncology, and

,

Mary Cushman

¹ Department of Medicine, Division of Hematology, Oncology, and

² Department of Pathology, University of Vermont, Burlington, VT, USA

,

Frits R. Rosendaal

³ Department of Clinical Epidemiology and the Hemostasis and Thrombosis Research Center Leiden University Medical Center, Leiden, The Netherlands

› Author Affiliations

Abstract

Summary

We studied the association of D-dimer with the risk of deep vein thrombosis (DVT). D-dimer was measured in 474 patients more than 6 months after diagnosis of a first DVT and in 474 age-and sexmatched controls. For D-dimer above the 70th percentile (130.5 ng/ml), the odds ratio (OR) for DVT was 2.2 (95% CI, 1.6-2.9). The association was unchanged with adjustment for other risk factors. Excluding participants with Factor V Leiden, prothrombin 20210A, or factors VIIIc or IX above the 90th percentile, the OR was 1.6 (95% CI, 1.1-2.3). The risks of DVT with the joint presence of high D-dimer and either factor V Leiden or prothrombin 20210A were increased 12.4-fold (95% CI 5.6-27.7) and 7.2-fold (95% CI 2.1-25.1), respectively. Higher Ddimer concentration was associated with the risk of DVT, and was supra-additive to the risks associated with factor V Leiden and the prothrombin 20210A variant. Persistence of this association in the absence of other hemostatic risk factors for DVT suggests that high D-dimer may be related to other, as yet unknown, risk factors for venous thrombosis. Confirmation of these findings is desirable.

Keywords

Deep vein thrombosis - D-dimer - blood coagulation - risk factor

Full Text

References

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