Download PDF
Thromb Haemost 2004; 92(03): 670-671
DOI: 10.1055/s-0037-1613741
Letter to the Editor
Schattauer GmbH

Does haemodilution produce a hypercoagulable state?

Volker Kretschmer
1   Institute of Transfusion Medicine and Haemostaseology, University Hospital, Philipps University Marburg, Germany
,
Anton Daraktchiev
1   Institute of Transfusion Medicine and Haemostaseology, University Hospital, Philipps University Marburg, Germany
,
Ralf Karger
1   Institute of Transfusion Medicine and Haemostaseology, University Hospital, Philipps University Marburg, Germany
› Author Affiliations
Further Information

Publication History

Received 07 April 2004

Accepted after resubmission 07 July 2004

Publication Date:
15 December 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Ruttmann TG. Haemodilution enhances coagulation (Editorial). Br J Anaesth 2002; 88: 470-2.
    CrossrefPubMedGoogle Scholar
  • 2 Ruttmann TG, James MFM, Viljoen JF. Haemodilution induces a hypercoagulable state. Br J Anaesth 1996; 76: 412-4.
    CrossrefPubMedGoogle Scholar
  • 3 Ruttmann TG, James MFM, Aronson I. In vivo investigation into the effects of haemodilution with hydroxyethyl starch (200/0.5) and normal saline on coagulation. Br J Anaesth 1998; 80: 612-6.
    CrossrefPubMedGoogle Scholar
  • 4 Ng KFJ, Lam CCK, Chan LC. In vivo effect of haemodilution with saline on coagulation: a randomized controlled trial. Br J Anaesth 2002; 88: 475-80.
    CrossrefPubMedGoogle Scholar
  • 5 Iselin BM, Willimann PF, Seifert B. et al. Isolated reduction of haematocrit does not compromise in vitro blood coagulation. Br J Anaesth 2001; 87: 246-9.
    CrossrefPubMedGoogle Scholar
  • 6 Hellem AJ, Borchgrevink CF, Ames SB. The role of red cells in haemostasis: the relation between haematocrit, bleeding time and platelet adhesiveness. Br J Haematol 1961; 07: 42-50.
    CrossrefPubMedGoogle Scholar
  • 7 Fernandez F, Goudable C, Sie PT-TH. et al. Low haematocrit and prolonged bleeding time in uraemic patients: effect of red cell transfusion. Br J Haematol 1985; 59: 139-48.
    CrossrefPubMedGoogle Scholar
  • 8 Valeri CR, Cassidy G, Pivacek LE. et al. Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss. Transfusion 2001; 41: 977-83.
    CrossrefPubMedGoogle Scholar
  • 9 Fries D, Innerhofer P, Klingler A. et al. The effect of the combined administration of colloids and lactated Ringer’s solution on the coagulation system: an in vitro study using thromb-elastograph® coagulation analysis (ROTEG®). Anesth Analg 2002; 94: 1280-7.
    CrossrefPubMedGoogle Scholar
  • 10 Innerhofer P, Fries D, Margreiter J. et al. The effects of perioperatively administered colloids and crystalloids on primary platelet-mediated hemostasis and clot formation. Anesth Analg 2002; 95: 858-65.
    CrossrefPubMedGoogle Scholar
  • 11 Kratzer MA, Born GV. Simulation of primary haemostasis in vitro. Haemostasis 1985; 15: 357-62.
    PubMedGoogle Scholar
  • 12 Kretschmer V, Weippert-Kretschmer M. Determination and treatment of disorders of primary hemostasis - experience with routine application of the in vitro bleeding test. Hiimostaseologie 1999; 19: 168-75.
    PubMedGoogle Scholar
  • 13 Innerhofer P, Fries D, Klingler A. et al. The effect of haemodilution on coagulation (Letter). Br J Anaesth 2003; 90: 809-10.
    CrossrefPubMedGoogle Scholar
  • 14 Fries D, Streif W, Margreiter J. et al. The effects of perioperatively administered crystalloids and colloids on concentrations of molecular markers of activated coagulation and fibrinolysis. Blood Coagul Fibrinolysis 2004; 15: 213-9.
    CrossrefPubMedGoogle Scholar