Thromb Haemost 1998; 79(02): 359-361
DOI: 10.1055/s-0037-1614992
Letters to the Editor
Schattauer GmbH

The Histidin-rich Glycoprotein Pro186/Ser Polymorphism Is not Related to Myocardial Infarction in the ECTIM Study

Stefan-Martin Herrmann
1   Institut National de la Santé et de la Recherche Médicale (INSERM) SC7, Paris, INSERM U258, Paris
,
Odette Poirier
1   Institut National de la Santé et de la Recherche Médicale (INSERM) SC7, Paris, INSERM U258, Paris
,
Viviane Nicaud
1   Institut National de la Santé et de la Recherche Médicale (INSERM) SC7, Paris, INSERM U258, Paris
,
Jean-Bernard Ruidavets
2   MONICA Project Toulouse, France
,
Alun Evans
3   MONICA Project Belfast, UK
,
Dominique Arveiler
4   MONICA Project Strasbourg
,
Gerald Luc
5   MONICA Project Lille
,
Lucienne Bara
6   Laboratoire de Thrombose Expérimentale, Université Paris VI, France
,
François Cambien
1   Institut National de la Santé et de la Recherche Médicale (INSERM) SC7, Paris, INSERM U258, Paris
› Author Affiliations
Further Information

Publication History

Received 16 April 1997

Accepted after resubmission 17 September 1997

Publication Date:
08 December 2017 (online)

Summary

The histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro186/Ser polymorphism of the HRG gene, which is known to strongly affect plasma HRG levels, in a large multicenter case-control study of myocardial infarction (MI). The results failed to demonstrate any association between the polymorphism and MI or angiographically assessed coronary stenosis.

 
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