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Thromb Haemost 1998; 79(06): 1126-1129
DOI: 10.1055/s-0037-1615028
DOI: 10.1055/s-0037-1615028
Rapid Communication
Polymorphism of the Platelet Glycoprotein IIIa Gene in Patients with Coronary Stenosis
Further Information
Publication History
Received
13 November 1997
Accepted after resubmission
24 February 1998
Publication Date:
07 December 2017 (online)
Summary
Based on genetic variability, structural differences in the glycoprotein IIb/IIIa platelet receptor for adhesive proteins result in individual differences in the thrombogenicity of platelets. Recent studies suggest a controversial association between a genetic polymorphism of the glycoprotein IIIa gene (PlA2) and the risk of coronary artery disease. In our study, the prevalence of the PlA2 allele in a group of patients undergoing percutaneous coronary revascularization was 37%, a value significantly higher than in controls [13%, odds ratio (OR) = 3.93, 95% CI, 1.84 to 8.53] suggesting a significant association between this polymorphism and documented coronary stenosis, which is strongest among <60 years old patients (OR = 12.30, 95% CI, 2.98 to 70.93). This polymorphism represents an inherited risk factor for severe cardiovascular disease due to coronary occlusion.
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