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Nuklearmedizin 1981; 20(01): 40-45
DOI: 10.1055/s-0037-1620715
Originalarbeiten – Original Articles
Schattauer GmbH

Differences between 201T1 and 43K Tissue Distribution in Rested and Exercised Rats

Unterschiede in der 201T1 und 43K Gewebsverteilung in ausgeruhten und ermüdeten Ratten
J. G. Llaurado
1   From the Nuclear Medicine and Research Services of Veterans Administration Medical Center, Marquette University and The Medical College of Wisconsin, Milwaukee, Wisc., USA
,
Jane A. Madden
1   From the Nuclear Medicine and Research Services of Veterans Administration Medical Center, Marquette University and The Medical College of Wisconsin, Milwaukee, Wisc., USA
,
G.A. Smith
1   From the Nuclear Medicine and Research Services of Veterans Administration Medical Center, Marquette University and The Medical College of Wisconsin, Milwaukee, Wisc., USA
› Author Affiliations
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Publication History

Received: 06 August 1980

Publication Date:
09 January 2018 (online)

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A comparison is made of relative organ-to-plasma uptake of 43K and 201T1 in rats at rest and after exercise (two hour swimming). Organs were obtained 0.5 or 3 hrs after radionuclide injection. Thus, there were four groups each for 43K and 201T1. For 201Tl the triad kidneys-heart-adrenals was very consistent throughout the four experimental situations in showing the highest uptake, whereas for 43K adrenals-heart-liver predominated at 0.5 hrs and thymus-liver at 3 hrs. The ratio 201Tl/43K in myocardium was always greater than unity in all four experimental situations. The heart-to-lung and heart-to-liver uptake ratios were lower in all cases for 43K vs. 201T1. One of the most important findings was that exercise always determined an increase of these ratios for 201T1, but it had an unfavorable effect on the 43K heart/lung ratio and no definite effect on the 43K heart/liver ratio. Our findings are analyzed in the light of previous publications. It is concluded that these two ions have biologically important different characteristics and that excessive and seemingly unjustified emphasis has been made on their physiological similarity.

Es wurde die relative Organ/Plasma Aufnahme von 43K und 201T1 bei Ratten nach vorausgegangener Ruhe und nach physikalischer Übung (2stündigem Schwimmen) verglichen. Die Organe wurden 0,5 und 3 Stunden nach einer Radio-nuklid-Injektion untersucht. Es wurden vier Gruppen für 43K und vier für 201T1 gebildet. Die Dreiergruppe Niere-Herz-Nebenniere verhielt sich in den vier Versuchen mit 201Tl sehr regelmäßig und zeigte durchwegs die höchste Nuklid-Aufnahme. Hingegen überwog bei 43K die Gruppe Nebenniere-Herz-Leber im 0,5-Stunden-Versuch und die Gruppe Thymus-Leber im 3-Stunden-Versuch. Das Verhältnis 201Tl/43K in Herzmuskel war in allen vier Versuchen größer als eins. Das Verhältnis Herz-Lunge und Herz-Leber war in allen Versuchen für 43K kleiner als für 201T1. Von besonderem Interesse war die Beobachtung, daß körperliche Anstrengung in allen Experimenten die oben angeführten Verhältniszahlen für 201Tl vergrößerten, aber das Ergebnis für 43K Herz-Lunge verkleinerten. Im Versuchsergebnis 43K Herz-Leber konnte kein merkbarer Einfluß festgestellt werden. Unsere Ergebnisse wurden mit früheren Publikationen verglichen und der Schluß gezogen, daß die beiden Ionen biologisch wichtige Unterschiede aufweisen und ihre physiologische Ähnlichkeit zu Unrecht herausgestrichen wurde.

 

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